deptropine-3144 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the deptropine-3144 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ATF5 activating transcription factor 5
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BNC2 basonuclin 2
BRD4 bromodomain containing 4
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF16 chromosome 11 open reading frame 16
C16ORF58 chromosome 16 open reading frame 58
C6 complement component 6
CARM1 coactivator-associated arginine methyltransferase 1
CD6 CD6 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD8B CD8b molecule
CDH8 cadherin 8, type 2
CGA glycoprotein hormones, alpha polypeptide
CIC capicua transcriptional repressor
CIDEB cell death-inducing DFFA-like effector b
CNPY4 canopy FGF signaling regulator 4
CRABP2 cellular retinoic acid binding protein 2
CTC1 CTS telomere maintenance complex component 1
CTDNEP1 CTD nuclear envelope phosphatase 1
CYLD cylindromatosis (turban tumor syndrome)
DEFB1 defensin, beta 1
DHRS12 dehydrogenase/reductase (SDR family) member 12
DNM1 dynamin 1
DPEP2 dipeptidase 2
DTNB dystrobrevin, beta
DUSP8 dual specificity phosphatase 8
ENDOD1 endonuclease domain containing 1
EPHB4 EPH receptor B4
F12 coagulation factor XII (Hageman factor)
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM65A family with sequence similarity 65, member A
FBXL18 F-box and leucine-rich repeat protein 18
FLII flightless I homolog (Drosophila)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GPR1 G protein-coupled receptor 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IFT140 intraflagellar transport 140
IL27RA interleukin 27 receptor, alpha
IRF4 interferon regulatory factor 4
KHSRP KH-type splicing regulatory protein
KLF3 Kruppel-like factor 3 (basic)
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LIPG lipase, endothelial
LPPR1 lipid phosphate phosphatase-related protein type 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP2K7 mitogen-activated protein kinase kinase 7
MFAP3L microfibrillar-associated protein 3-like
MTCL1 microtubule crosslinking factor 1
MUC1 mucin 1, cell surface associated
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NCAM1 neural cell adhesion molecule 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPAS2 neuronal PAS domain protein 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUCB1 nucleobindin 1
NUP54 nucleoporin 54kDa
OBSL1 obscurin-like 1
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PALLD palladin, cytoskeletal associated protein
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POU2F2 POU class 2 homeobox 2
PPARD peroxisome proliferator-activated receptor delta
PRSS53 protease, serine, 53
QTRT1 queuine tRNA-ribosyltransferase 1
RBM42 RNA binding motif protein 42
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RECQL5 RecQ protein-like 5
RGS14 regulator of G-protein signaling 14
RIBC2 RIB43A domain with coiled-coils 2
RIF1 replication timing regulatory factor 1
RNF6 ring finger protein (C3H2C3 type) 6
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIX3 SIX homeobox 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLN sarcolipin
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS2 suppressor of cytokine signaling 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAOK2 TAO kinase 2
TICAM1 toll-like receptor adaptor molecule 1
TLN1 talin 1
TNC tenascin C
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRD T cell receptor delta locus
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
ZNF324 zinc finger protein 324
ZNF580 zinc finger protein 580
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACPP acid phosphatase, prostate
ADAM10 ADAM metallopeptidase domain 10
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AURKB aurora kinase B
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNL2 cyclin L2
CDC37 cell division cycle 37
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHM choroideremia (Rab escort protein 1)
CORO1C coronin, actin binding protein, 1C
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DNAL4 dynein, axonemal, light chain 4
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP5 elongator acetyltransferase complex subunit 5
EML4 echinoderm microtubule associated protein like 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC6 excision repair cross-complementation group 6
EXOC5 exocyst complex component 5
FKBP5 FK506 binding protein 5
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GTF2I general transcription factor IIi
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H2BI histone cluster 1, H2bi
IDI2-AS1 IDI2 antisense RNA 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IPO8 importin 8
KCTD20 potassium channel tetramerization domain containing 20
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMAN1 lectin, mannose-binding, 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFSD6 major facilitator superfamily domain containing 6
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMD3 NMD3 ribosome export adaptor
ODF2 outer dense fiber of sperm tails 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
R3HCC1L R3H domain and coiled-coil containing 1-like
RFXAP regulatory factor X-associated protein
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RPE ribulose-5-phosphate-3-epimerase
SALL2 spalt-like transcription factor 2
SCYL2 SCY1-like 2 (S. cerevisiae)
SENP7 SUMO1/sentrin specific peptidase 7
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SGMS1 sphingomyelin synthase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC16A4 solute carrier family 16, member 4
SLC25A40 solute carrier family 25, member 40
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMG9 SMG9 nonsense mediated mRNA decay factor
SNRPN small nuclear ribonucleoprotein polypeptide N
SP1 Sp1 transcription factor
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SYNC syncoilin, intermediate filament protein
TGFBR1 transforming growth factor, beta receptor 1
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TMEM230 transmembrane protein 230
TMEM50B transmembrane protein 50B
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRIM25 tripartite motif containing 25
TWISTNB TWIST neighbor
TWSG1 twisted gastrulation BMP signaling modulator 1
UTRN utrophin
YY2 YY2 transcription factor
ZNF155 zinc finger protein 155
ZNF225 zinc finger protein 225
ZNF227 zinc finger protein 227
ZNF253 zinc finger protein 253
ZNF480 zinc finger protein 480
ZNF510 zinc finger protein 510