deptropine-5118 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the deptropine-5118 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACRV1 acrosomal vesicle protein 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAM22 ADAM metallopeptidase domain 22
AMIGO2 adhesion molecule with Ig-like domain 2
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARTN artemin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BIRC3 baculoviral IAP repeat containing 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF54 chromosome 1 open reading frame 54
C4BPA complement component 4 binding protein, alpha
CA5B carbonic anhydrase VB, mitochondrial
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CATR1 CATR tumorigenicity conversion 1
CCKAR cholecystokinin A receptor
CCNO cyclin O
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLDN1 claudin 1
CLSTN3 calsyntenin 3
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CREB3L1 cAMP responsive element binding protein 3-like 1
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYSLTR1 cysteinyl leukotriene receptor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND3 DENN/MADD domain containing 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPB41 erythrocyte membrane protein band 4.1
ERO1LB ERO1-like beta (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF2 fibroblast growth factor 2 (basic)
FGFR2 fibroblast growth factor receptor 2
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GLI2 GLI family zinc finger 2
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGLJ3 immunoglobulin lambda joining 3
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INHBA inhibin, beta A
IRF4 interferon regulatory factor 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KIAA0226L KIAA0226-like
KIAA1109 KIAA1109
KIDINS220 kinase D-interacting substrate, 220kDa
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LENEP lens epithelial protein
LPL lipoprotein lipase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MIIP migration and invasion inhibitory protein
NEUROD4 neuronal differentiation 4
NEUROG2 neurogenin 2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
PTX3 pentraxin 3, long
RASA3 RAS p21 protein activator 3
RBM12B RNA binding motif protein 12B
RGS10 regulator of G-protein signaling 10
RIN3 Ras and Rab interactor 3
RPL10L ribosomal protein L10-like
RUSC2 RUN and SH3 domain containing 2
SAA3P serum amyloid A3 pseudogene
SAMD4A sterile alpha motif domain containing 4A
SARM1 sterile alpha and TIR motif containing 1
SDF2L1 stromal cell-derived factor 2-like 1
SERHL2 serine hydrolase-like 2
SFTPB surfactant protein B
SIGLEC8 sialic acid binding Ig-like lectin 8
SLA Src-like-adaptor
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SORBS1 sorbin and SH3 domain containing 1
STC2 stanniocalcin 2
SVIL supervillin
TFIP11 tuftelin interacting protein 11
TGFB2 transforming growth factor, beta 2
TK2 thymidine kinase 2, mitochondrial
TOM1 target of myb1 (chicken)
TRIB3 tribbles pseudokinase 3
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF235 zinc finger protein 235
ZNF768 zinc finger protein 768
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACAD8 acyl-CoA dehydrogenase family, member 8
ADCY6 adenylate cyclase 6
AEN apoptosis enhancing nuclease
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD36B ankyrin repeat domain 36B
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BOLA1 bolA family member 1
C1R complement component 1, r subcomponent
CBX7 chromobox homolog 7
CDC7 cell division cycle 7
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHST10 carbohydrate sulfotransferase 10
CLEC16A C-type lectin domain family 16, member A
CLK1 CDC-like kinase 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXORF56 chromosome X open reading frame 56
DCAF4 DDB1 and CUL4 associated factor 4
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND5B DENN/MADD domain containing 5B
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DNMBP dynamin binding protein
EPM2AIP1 EPM2A (laforin) interacting protein 1
ETV4 ets variant 4
F2R coagulation factor II (thrombin) receptor
F8 coagulation factor VIII, procoagulant component
FAM172A family with sequence similarity 172, member A
FBXL15 F-box and leucine-rich repeat protein 15
FLRT3 fibronectin leucine rich transmembrane protein 3
GAREM GRB2 associated, regulator of MAPK1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
IL11RA interleukin 11 receptor, alpha
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IPP intracisternal A particle-promoted polypeptide
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KDM5C lysine (K)-specific demethylase 5C
KIAA1462 KIAA1462
KIAA1549L KIAA1549-like
LBR lamin B receptor
LIN7B lin-7 homolog B (C. elegans)
LMNB1 lamin B1
LOC390998 ribosomal protein L10 pseudogene
LRRC37A3 leucine rich repeat containing 37, member A3
LZTR1 leucine-zipper-like transcription regulator 1
MANBA mannosidase, beta A, lysosomal
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MED24 mediator complex subunit 24
MGC12488
MICALL2 MICAL-like 2
NOD1 nucleotide-binding oligomerization domain containing 1
NRSN2 neurensin 2
ORC1 origin recognition complex, subunit 1
OSR2 odd-skipped related transciption factor 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAIP2B poly(A) binding protein interacting protein 2B
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALMD palmdelphin
PARP3 poly (ADP-ribose) polymerase family, member 3
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRKCD protein kinase C, delta
PRKG2 protein kinase, cGMP-dependent, type II
PSRC1 proline/serine-rich coiled-coil 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SALL2 spalt-like transcription factor 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
TBL3 transducin (beta)-like 3
TBX19 T-box 19
TEX40 testis expressed 40
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TRIM66 tripartite motif containing 66
TRIM9 tripartite motif containing 9
TRPS1 trichorhinophalangeal syndrome I
TTC31 tetratricopeptide repeat domain 31
UGT8 UDP glycosyltransferase 8
USP27X ubiquitin specific peptidase 27, X-linked
WDR37 WD repeat domain 37
WDR4 WD repeat domain 4
WDR76 WD repeat domain 76
WNT7A wingless-type MMTV integration site family, member 7A
YIPF1 Yip1 domain family, member 1
ZBTB6 zinc finger and BTB domain containing 6
ZNF107 zinc finger protein 107
ZNF365 zinc finger protein 365
ZNF675 zinc finger protein 675
ZNF702P zinc finger protein 702, pseudogene
ZNF767P zinc finger family member 767, pseudogene