deptropine-5543 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the deptropine-5543 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRA1A adrenoceptor alpha 1A
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKLE2 ankyrin repeat and LEM domain containing 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAT1 alpha tubulin acetyltransferase 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BMP15 bone morphogenetic protein 15
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2 complement component 2
C6ORF10 chromosome 6 open reading frame 10
C7ORF69 chromosome 7 open reading frame 69
CARD9 caspase recruitment domain family, member 9
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCRL2 chemokine (C-C motif) receptor-like 2
CDC14B cell division cycle 14B
CDHR2 cadherin-related family member 2
CDKL3 cyclin-dependent kinase-like 3
CNTD2 cyclin N-terminal domain containing 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL8A2 collagen, type VIII, alpha 2
COL9A3 collagen, type IX, alpha 3
CSF1R colony stimulating factor 1 receptor
CYHR1 cysteine/histidine-rich 1
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
DTNA dystrobrevin, alpha
EDRF1 erythroid differentiation regulatory factor 1
ESRRA estrogen-related receptor alpha
FHL1 four and a half LIM domains 1
FLJ11710 uncharacterized protein FLJ11710
FMOD fibromodulin
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GJA4 gap junction protein, alpha 4, 37kDa
GJA9 gap junction protein, alpha 9, 59kDa
GPR22 G protein-coupled receptor 22
GRB7 growth factor receptor-bound protein 7
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSN gelsolin
HIST1H1E histone cluster 1, H1e
HNF1B HNF1 homeobox B
HYAL3 hyaluronoglucosaminidase 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INVS inversin
IPO5 importin 5
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
LAMP3 lysosomal-associated membrane protein 3
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIMD1 LIM domains containing 1
LTBP2 latent transforming growth factor beta binding protein 2
LTC4S leukotriene C4 synthase
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MED25 mediator complex subunit 25
MTA2 metastasis associated 1 family, member 2
MVK mevalonate kinase
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLXNA2 plexin A2
POFUT1 protein O-fucosyltransferase 1
POLG polymerase (DNA directed), gamma
PRB1 proline-rich protein BstNI subfamily 1
PSEN2 presenilin 2
PSG9 pregnancy specific beta-1-glycoprotein 9
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFPL1S RFPL1 antisense RNA 1
RIMS2 regulating synaptic membrane exocytosis 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRT3 sirtuin 3
SLC12A8 solute carrier family 12, member 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A10 solute carrier family 26, member 10
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOS2 son of sevenless homolog 2 (Drosophila)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY4 sprouty homolog 4 (Drosophila)
STK38 serine/threonine kinase 38
SYBU syntabulin (syntaxin-interacting)
TAPBP TAP binding protein (tapasin)
THOC5 THO complex 5
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
ZBED4 zinc finger, BED-type containing 4
ZFPL1 zinc finger protein-like 1
ZNF41 zinc finger protein 41
ZNF747 zinc finger protein 747
ZYX zyxin

decreased expression

Symbol Name
AFG3L2 AFG3-like AAA ATPase 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ATAD3A ATPase family, AAA domain containing 3A
BAG4 BCL2-associated athanogene 4
BIRC7 baculoviral IAP repeat containing 7
BTBD2 BTB (POZ) domain containing 2
C9ORF9 chromosome 9 open reading frame 9
CAPN15 calpain 15
CAPN5 calpain 5
CCNE1 cyclin E1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC7 cell division cycle 7
CDK9 cyclin-dependent kinase 9
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CGREF1 cell growth regulator with EF-hand domain 1
CHST10 carbohydrate sulfotransferase 10
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF10 DDB1 and CUL4 associated factor 10
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DTX4 deltex 4, E3 ubiquitin ligase
F2R coagulation factor II (thrombin) receptor
FAM172A family with sequence similarity 172, member A
FAM184A family with sequence similarity 184, member A
FBXO22 F-box protein 22
FGD6 FYVE, RhoGEF and PH domain containing 6
FJX1 four jointed box 1 (Drosophila)
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNL1 guanine nucleotide binding protein-like 1
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
HOXC10 homeobox C10
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KDM5C lysine (K)-specific demethylase 5C
LAMA5 laminin, alpha 5
LAMB2 laminin, beta 2 (laminin S)
LAX1 lymphocyte transmembrane adaptor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRP2 low density lipoprotein receptor-related protein 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAMLD1 mastermind-like domain containing 1
MAP1S microtubule-associated protein 1S
MON1B MON1 secretory trafficking family member B
MOSPD3 motile sperm domain containing 3
MSI1 musashi RNA-binding protein 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NIPAL2 NIPA-like domain containing 2
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NSD1 nuclear receptor binding SET domain protein 1
ONECUT2 one cut homeobox 2
OTUD3 OTU deubiquitinase 3
PANK4 pantothenate kinase 4
PGBD5 piggyBac transposable element derived 5
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POMZP3 POM121 and ZP3 fusion
POPDC3 popeye domain containing 3
PPCDC phosphopantothenoylcysteine decarboxylase
PRR14L proline rich 14-like
PTK6 protein tyrosine kinase 6
R3HCC1L R3H domain and coiled-coil containing 1-like
RGS19 regulator of G-protein signaling 19
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF219 ring finger protein 219
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SAMHD1 SAM domain and HD domain 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIRT6 sirtuin 6
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SNORA21 small nucleolar RNA, H/ACA box 21
SP140L SP140 nuclear body protein-like
SPINK4 serine peptidase inhibitor, Kazal type 4
STBD1 starch binding domain 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYCP2 synaptonemal complex protein 2
THOP1 thimet oligopeptidase 1
TMEM104 transmembrane protein 104
TMEM132A transmembrane protein 132A
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC23 tetratricopeptide repeat domain 23
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
URM1 ubiquitin related modifier 1
VAV1 vav 1 guanine nucleotide exchange factor
ZFHX2 zinc finger homeobox 2
ZNF226 zinc finger protein 226
ZNF254 zinc finger protein 254