deptropine-6523 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the deptropine-6523 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
AK2 adenylate kinase 2
ALS2CL ALS2 C-terminal like
ASPH aspartate beta-hydroxylase
BBS9 Bardet-Biedl syndrome 9
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BGN biglycan
BTG2 BTG family, member 2
C19ORF73 chromosome 19 open reading frame 73
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC71 coiled-coil domain containing 71
CD6 CD6 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDC25A cell division cycle 25A
CLTA clathrin, light chain A
CNN3 calponin 3, acidic
CNTNAP2 contactin associated protein-like 2
CORO2B coronin, actin binding protein, 2B
CRHR2 corticotropin releasing hormone receptor 2
CST1 cystatin SN
DICER1 dicer 1, ribonuclease type III
DNALI1 dynein, axonemal, light intermediate chain 1
DTNA dystrobrevin, alpha
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FBN1 fibrillin 1
FGB fibrinogen beta chain
FLJ11292
FOXA2 forkhead box A2
FSCN1 fascin actin-bundling protein 1
FYB FYN binding protein
GAP43 growth associated protein 43
GJA8 gap junction protein, alpha 8, 50kDa
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPR135 G protein-coupled receptor 135
GPR182 G protein-coupled receptor 182
GPR85 G protein-coupled receptor 85
GRIA1 glutamate receptor, ionotropic, AMPA 1
GYPB glycophorin B (MNS blood group)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCG4 HLA complex group 4 (non-protein coding)
HDAC5 histone deacetylase 5
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HP1BP3 heterochromatin protein 1, binding protein 3
HYAL4 hyaluronoglucosaminidase 4
ICAM1 intercellular adhesion molecule 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL1RN interleukin 1 receptor antagonist
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLK7 kallikrein-related peptidase 7
KNG1 kininogen 1
LRRC40 leucine rich repeat containing 40
MSI1 musashi RNA-binding protein 1
MTSS1 metastasis suppressor 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NID1 nidogen 1
NUDCD3 NudC domain containing 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PCDHGA10 protocadherin gamma subfamily A, 10
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PEX5 peroxisomal biogenesis factor 5
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNC1 plexin C1
POU2F2 POU class 2 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PTAFR platelet-activating factor receptor
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS20 regulator of G-protein signaling 20
RUNX1 runt-related transcription factor 1
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPD surfactant protein D
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNED1 sushi, nidogen and EGF-like domains 1
SPON1 spondin 1, extracellular matrix protein
TFCP2 transcription factor CP2
TRD T cell receptor delta locus
TRIL TLR4 interactor with leucine-rich repeats
TRIM3 tripartite motif containing 3
TTC38 tetratricopeptide repeat domain 38
WIPF1 WAS/WASL interacting protein family, member 1
ZC3H7B zinc finger CCCH-type containing 7B
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF222 zinc finger protein 222
ZNF384 zinc finger protein 384
ZNF407 zinc finger protein 407
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
AZI2 5-azacytidine induced 2
BAG4 BCL2-associated athanogene 4
BMP15 bone morphogenetic protein 15
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF80 chromosome 11 open reading frame 80
C5 complement component 5
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC132 coiled-coil domain containing 132
CHEK2 checkpoint kinase 2
CHRM3 cholinergic receptor, muscarinic 3
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CPOX coproporphyrinogen oxidase
CTAGE9 CTAGE family, member 9
DDIT3 DNA-damage-inducible transcript 3
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FAM155B family with sequence similarity 155, member B
FANCC Fanconi anemia, complementation group C
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GID4 GID complex subunit 4
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRTP1 growth hormone regulated TBC protein 1
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA4 homeobox A4
IDI2-AS1 IDI2 antisense RNA 1
IFT54 intraflagellar transport 54
IGSF1 immunoglobulin superfamily, member 1
IL4R interleukin 4 receptor
IMPAD1 inositol monophosphatase domain containing 1
KIAA0556 KIAA0556
KLHL25 kelch-like family member 25
KREMEN2 kringle containing transmembrane protein 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LINC00115 long intergenic non-protein coding RNA 115
LMBR1L limb development membrane protein 1-like
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC730101 uncharacterized LOC730101
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC8E leucine rich repeat containing 8 family, member E
LYRM9 LYR motif containing 9
MANBA mannosidase, beta A, lysosomal
MBIP MAP3K12 binding inhibitory protein 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MORC3 MORC family CW-type zinc finger 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTCL1 microtubule crosslinking factor 1
NFE2L3 nuclear factor, erythroid 2-like 3
NOL12 nucleolar protein 12
NRBF2 nuclear receptor binding factor 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUPL2 nucleoporin like 2
PAQR3 progestin and adipoQ receptor family member III
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PER3 period circadian clock 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRR15L proline rich 15-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB23 RAB23, member RAS oncogene family
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF25 ring finger protein 25
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL10L ribosomal protein L10-like
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SECTM1 secreted and transmembrane 1
SHARPIN SHANK-associated RH domain interactor
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPIDR scaffolding protein involved in DNA repair
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYBU syntabulin (syntaxin-interacting)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSPAN2 tetraspanin 2
TTBK2 tau tubulin kinase 2
UBXN8 UBX domain protein 8
WNT10B wingless-type MMTV integration site family, member 10B
ZNF10 zinc finger protein 10
ZNF280D zinc finger protein 280D
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZNF701 zinc finger protein 701