dequalinium chloride-5396 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the dequalinium chloride-5396 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ADAMDEC1 ADAM-like, decysin 1
AFAP1 actin filament associated protein 1
ALDOB aldolase B, fructose-bisphosphate
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATXN1 ataxin 1
BHLHE40 basic helix-loop-helix family, member e40
C10ORF95 chromosome 10 open reading frame 95
C7ORF26 chromosome 7 open reading frame 26
CD34 CD34 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC14B cell division cycle 14B
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP350 centrosomal protein 350kDa
CFAP69 cilia and flagella associated protein 69
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNTN1 contactin 1
COL1A1 collagen, type I, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPEB1 cytoplasmic polyadenylation element binding protein 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DRD1 dopamine receptor D1
DUSP4 dual specificity phosphatase 4
EMP3 epithelial membrane protein 3
EPHA3 EPH receptor A3
ETV5 ets variant 5
FLOT1 flotillin 1
GHRHR growth hormone releasing hormone receptor
GSAP gamma-secretase activating protein
GSPT2 G1 to S phase transition 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HFE hemochromatosis
HOXA11 homeobox A11
HSPG2 heparan sulfate proteoglycan 2
ICOSLG inducible T-cell co-stimulator ligand
IL21 interleukin 21
INHBE inhibin, beta E
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF8 Kruppel-like factor 8
LMAN1 lectin, mannose-binding, 1
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MDM4 MDM4, p53 regulator
MT1F metallothionein 1F
MYO1B myosin IB
N4BP2L2 NEDD4 binding protein 2-like 2
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NOL12 nucleolar protein 12
NRIP3 nuclear receptor interacting protein 3
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PEX3 peroxisomal biogenesis factor 3
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLAU plasminogen activator, urokinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RND1 Rho family GTPase 1
RPL10L ribosomal protein L10-like
RUNX1 runt-related transcription factor 1
SLC35E2 solute carrier family 35, member E2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCAIP synuclein, alpha interacting protein
SOS2 son of sevenless homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
TCF4 transcription factor 4
TES testin LIM domain protein
TIGD6 tigger transposable element derived 6
TMCC2 transmembrane and coiled-coil domain family 2
TMEM19 transmembrane protein 19
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WIZ widely interspaced zinc finger motifs
ZNF124 zinc finger protein 124
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ALPK1 alpha-kinase 1
ANKRD40 ankyrin repeat domain 40
ANP32A-IT1 ANP32A intronic transcript 1
ARSB arylsulfatase B
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP13A2 ATPase type 13A2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAG4 BCL2-associated athanogene 4
C2ORF44 chromosome 2 open reading frame 44
CCDC9 coiled-coil domain containing 9
CDC25A cell division cycle 25A
CEP170B centrosomal protein 170B
CES3 carboxylesterase 3
CHKB choline kinase beta
CLSPN claspin
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DOCK1 dedicator of cytokinesis 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM204A family with sequence similarity 204, member A
FAM46C family with sequence similarity 46, member C
FCHO1 FCH domain only 1
FKBP10 FK506 binding protein 10, 65 kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GRWD1 glutamate-rich WD repeat containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIRA histone cell cycle regulator
HOXC5 homeobox C5
HPSE heparanase
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IL17RA interleukin 17 receptor A
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISG15 ISG15 ubiquitin-like modifier
KAT2A K(lysine) acetyltransferase 2A
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC257152 uncharacterized LOC257152
LRP2 low density lipoprotein receptor-related protein 2
LRP5 low density lipoprotein receptor-related protein 5
MFSD12 major facilitator superfamily domain containing 12
MSMB microseminoprotein, beta-
MSX1 msh homeobox 1
MXD3 MAX dimerization protein 3
NDRG4 NDRG family member 4
NLRX1 NLR family member X1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5DC3 5'-nucleotidase domain containing 3
PACS1 phosphofurin acidic cluster sorting protein 1
PGBD5 piggyBac transposable element derived 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PTDSS2 phosphatidylserine synthase 2
RAB3D RAB3D, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RECQL4 RecQ protein-like 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RLN1 relaxin 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPUSD2 RNA pseudouridylate synthase domain containing 2
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLIT2 slit homolog 2 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUOX sulfite oxidase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TET3 tet methylcytosine dioxygenase 3
TH tyrosine hydroxylase
TMEM104 transmembrane protein 104
TMEM209 transmembrane protein 209
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TTC4 tetratricopeptide repeat domain 4
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VASH2 vasohibin 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VWA1 von Willebrand factor A domain containing 1
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
WFS1 Wolfram syndrome 1 (wolframin)
ZMAT5 zinc finger, matrin-type 5
ZNF480 zinc finger protein 480
ZNF862 zinc finger protein 862