dermatomyositis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A myositis and is_a dermatitis that results_in inflammation located_in muscle and located_in skin. The disease may result from either a viral infection or an autoimmune reaction.|A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6) (Experimental Factor Ontology, EFO_0000398)
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Genes

258 genes co-occuring with the disease dermatomyositis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HARS histidyl-tRNA synthetase 1.77451
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.69678
TRIM24 tripartite motif containing 24 1.45089
HSPG2 heparan sulfate proteoglycan 2 1.40876
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 1.40176
AARS alanyl-tRNA synthetase 1.32716
TROVE2 TROVE domain family, member 2 1.27214
MUC1 mucin 1, cell surface associated 1.26298
TRIM21 tripartite motif containing 21 1.19618
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.19359
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.17722
CD4 CD4 molecule 1.14985
HLA-B major histocompatibility complex, class I, B 1.13712
TMEM11 transmembrane protein 11 1.12361
TNF tumor necrosis factor 1.07194
IFIH1 interferon induced with helicase C domain 1 1.05345
TARS threonyl-tRNA synthetase 1.04546
TRIM33 tripartite motif containing 33 1.01596
GARS glycyl-tRNA synthetase 1.01343
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.00457
LAMP3 lysosomal-associated membrane protein 3 0.952438
MX1 MX dynamin-like GTPase 1 0.870415
CRP C-reactive protein, pentraxin-related 0.86018
ICAM1 intercellular adhesion molecule 1 0.850354
CHD4 chromodomain helicase DNA binding protein 4 0.848716
MB myoglobin 0.832738
NARS asparaginyl-tRNA synthetase 0.826178
IL1A interleukin 1, alpha 0.819206
MORC3 MORC family CW-type zinc finger 3 0.781069
HLA-DMA major histocompatibility complex, class II, DM alpha 0.776568
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.774114
CD79A CD79a molecule, immunoglobulin-associated alpha 0.77207
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.760231
INSL6 insulin-like 6 0.75412
POMC proopiomelanocortin 0.748017
PRF1 perforin 1 (pore forming protein) 0.747204
CD68 CD68 molecule 0.746391
CCL2 chemokine (C-C motif) ligand 2 0.737054
IL17A interleukin 17A 0.734217
CLEC4C C-type lectin domain family 4, member C 0.729357
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.729357
VCAM1 vascular cell adhesion molecule 1 0.727738
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.710378
ISG15 ISG15 ubiquitin-like modifier 0.708767
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.706351
CCL21 chemokine (C-C motif) ligand 21 0.704742
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.70434
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.701526
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.683493
CCL19 chemokine (C-C motif) ligand 19 0.681894
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 0.681495
DMD dystrophin 0.67113
IL1B interleukin 1, beta 0.658818
WDR61 WD repeat domain 61 0.65288
VWF von Willebrand factor 0.650903
NCAM1 neural cell adhesion molecule 1 0.648138
ASB9 ankyrin repeat and SOCS box containing 9 0.644192
FTL ferritin, light polypeptide 0.637102
FTH1 ferritin, heavy polypeptide 1 0.637102
SFTPD surfactant protein D 0.635135
LILRP1 leukocyte immunoglobulin-like receptor pseudogene 1 0.62728
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.613965
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.608885
ANGPTL2 angiopoietin-like 2 0.60342
HMGB1 high mobility group box 1 0.597181
CYCS cytochrome c, somatic 0.583163
IL15 interleukin 15 0.580439
TLR3 toll-like receptor 3 0.579661
KRT34 keratin 34, type I 0.579272
TCN2 transcobalamin II 0.575772
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.575383
SAE1 SUMO1 activating enzyme subunit 1 0.575383
CXCL10 chemokine (C-X-C motif) ligand 10 0.573828
PAX7 paired box 7 0.569941
C1D C1D nuclear receptor corepressor 0.564889
CXCR3 chemokine (C-X-C motif) receptor 3 0.551298
SEPHS1 selenophosphate synthetase 1 0.541217
CD19 CD19 molecule 0.538118
UBA2 ubiquitin-like modifier activating enzyme 2 0.531154
ZBTB14 zinc finger and BTB domain containing 14 0.529608
PLCL1 phospholipase C-like 1 0.51188
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 0.507273
HOXC11 homeobox C11 0.504207
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.502292
DMBX1 diencephalon/mesencephalon homeobox 1 0.497703
HLA-A major histocompatibility complex, class I, A 0.490454
HLA-C major histocompatibility complex, class I, C 0.489311
CXCL9 chemokine (C-X-C motif) ligand 9 0.488549
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.485505
CHSY1 chondroitin sulfate synthase 1 0.485505
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.485125
ZFAT zinc finger and AT hook domain containing 0.483604
CD163 CD163 molecule 0.471089
KIF4A kinesin family member 4A 0.470711
STX17 syntaxin 17 0.469197
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.458241
IL2RA interleukin 2 receptor, alpha 0.457109
STAT4 signal transducer and activator of transcription 4 0.456732
CD276 CD276 molecule 0.453716
RPL14 ribosomal protein L14 0.451078
CAND1 cullin-associated and neddylation-dissociated 1 0.432646
CELF4 CUGBP, Elav-like family member 4 0.431519
S100A9 S100 calcium binding protein A9 0.431144
RMI2 RecQ mediated genome instability 2 0.428516
IRF7 interferon regulatory factor 7 0.424014
CD59 CD59 molecule, complement regulatory protein 0.423265
TNNT2 troponin T type 2 (cardiac) 0.419517
CCL20 chemokine (C-C motif) ligand 20 0.418394
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.415024
HSPA14 heat shock 70kDa protein 14 0.412031
SELE selectin E 0.409787
ACRC acidic repeat containing 0.401945
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.400453
PSIP1 PC4 and SFRS1 interacting protein 1 0.397098
BLK BLK proto-oncogene, Src family tyrosine kinase 0.395235
CCL4 chemokine (C-C motif) ligand 4 0.394118
TNMD tenomodulin 0.392629
IFNA1 interferon, alpha 1 0.391513
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.384079
HOXD4 homeobox D4 0.379626
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.377031
STAT1 signal transducer and activator of transcription 1, 91kDa 0.37592
PLXND1 plexin D1 0.37592
CCL3 chemokine (C-C motif) ligand 3 0.373698
IL6 interleukin 6 0.369628
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.369628
F8 coagulation factor VIII, procoagulant component 0.367779
TGFB1 transforming growth factor, beta 1 0.367779
IL18 interleukin 18 0.365932
SYT7 synaptotagmin VII 0.365193
HYLS1 hydrolethalus syndrome 1 0.363347
CHD3 chromodomain helicase DNA binding protein 3 0.356341
UTRN utrophin 0.353395
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.352291
IL2 interleukin 2 0.351555
SRP72 signal recognition particle 72kDa 0.349717
HOXD3 homeobox D3 0.348614
CKLF chemokine-like factor 0.346042
HLA-E major histocompatibility complex, class I, E 0.340539
MYOD1 myogenic differentiation 1 0.340539
CD1C CD1c molecule 0.337242
CENPB centromere protein B, 80kDa 0.33651
CD40 CD40 molecule, TNF receptor superfamily member 5 0.334681
SARDH sarcosine dehydrogenase 0.334315
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.334315
CD83 CD83 molecule 0.332121
CPLX1 complexin 1 0.331025
ADAM19 ADAM metallopeptidase domain 19 0.324823
THBS1 thrombospondin 1 0.324823
TRIM28 tripartite motif containing 28 0.320817
SYNM synemin, intermediate filament protein 0.318635
CXCL13 chemokine (C-X-C motif) ligand 13 0.316456
IFNG interferon, gamma 0.313552
SPP1 secreted phosphoprotein 1 0.312102
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.306672
HMGB3 high mobility group box 3 0.301254
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.300533
HOXB1 homeobox B1 0.297291
ALPPL2 alkaline phosphatase, placental-like 2 0.296211
ALPP alkaline phosphatase, placental 0.295851
ALPL alkaline phosphatase, liver/bone/kidney 0.295132
ANGPTL4 angiopoietin-like 4 0.289744
PDLIM7 PDZ and LIM domain 7 (enigma) 0.287235
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.28616
FAM167A family with sequence similarity 167, member A 0.279011
RPA2 replication protein A2, 32kDa 0.276514
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.275089
CENPC centromere protein C 0.272953
CAST calpastatin 0.272953
CD180 CD180 molecule 0.27153
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.269398
GEMIN4 gem (nuclear organelle) associated protein 4 0.269043
THBD thrombomodulin 0.264785
TGM2 transglutaminase 2 0.26266
CIDEC cell death-inducing DFFA-like effector c 0.262306
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.261245
FSTL1 follistatin-like 1 0.255594
DNASE1L3 deoxyribonuclease I-like 3 0.255594
FBN1 fibrillin 1 0.254536
TOP1 topoisomerase (DNA) I 0.25207
MAG myelin associated glycoprotein 0.249257
IFNL2 interferon, lambda 2 0.245747
CCL23 chemokine (C-C motif) ligand 23 0.243295
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.242245
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.242245
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.235964
CCL17 chemokine (C-C motif) ligand 17 0.230063
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.228333
IBSP integrin-binding sialoprotein 0.226952
SEPT1 septin 1 0.225229
NT5C1A 5'-nucleotidase, cytosolic IA 0.224884
TLR9 toll-like receptor 9 0.223509
CXCL12 chemokine (C-X-C motif) ligand 12 0.221108
COIL coilin 0.219398
EMX2 empty spiracles homeobox 2 0.219057
CD244 CD244 molecule, natural killer cell receptor 2B4 0.218374
CST7 cystatin F (leukocystatin) 0.216332
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.215314
SPTB spectrin, beta, erythrocytic 0.212945
CXCR5 chemokine (C-X-C motif) receptor 5 0.210253
ILF3 interleukin enhancer binding factor 3, 90kDa 0.206248
AJAP1 adherens junctions associated protein 1 0.203604
USP18 ubiquitin specific peptidase 18 0.201308
FOXP3 forkhead box P3 0.200006
CD207 CD207 molecule, langerin 0.199356
HBA2 hemoglobin, alpha 2 0.199033
TLR7 toll-like receptor 7 0.197742
ICOSLG inducible T-cell co-stimulator ligand 0.196779
MPO myeloperoxidase 0.194548
ISG20 interferon stimulated exonuclease gene 20kDa 0.192344
MRC1 mannose receptor, C type 1 0.192031
ANGPTL3 angiopoietin-like 3 0.188632
CD40LG CD40 ligand 0.184128
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.182666
ACPP acid phosphatase, prostate 0.182086
CXCL11 chemokine (C-X-C motif) ligand 11 0.177851
CD1B CD1b molecule 0.177851
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.177576
DSG3 desmoglein 3 0.177301
CCR7 chemokine (C-C motif) receptor 7 0.177301
ALX4 ALX homeobox 4 0.177029
NMS neuromedin S 0.174354
WRAP73 WD repeat containing, antisense to TP73 0.174093
PEG3 paternally expressed 3 0.172291
ACAA1 acetyl-CoA acyltransferase 1 0.170054
ANO5 anoctamin 5 0.167915
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.166768
IARS isoleucyl-tRNA synthetase 0.165435
FST follistatin 0.164359
ADAM10 ADAM metallopeptidase domain 10 0.161331
MIR133B microRNA 133b 0.161331
TGFB2 transforming growth factor, beta 2 0.160203
CD22 CD22 molecule 0.159302
HBA1 hemoglobin, alpha 1 0.158951
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.158097
MCAM melanoma cell adhesion molecule 0.144448
THBS4 thrombospondin 4 0.14372
TXNDC9 thioredoxin domain containing 9 0.143371
C4A complement component 4A (Rodgers blood group) 0.143218
MEPE matrix extracellular phosphoglycoprotein 0.142984
SYNE1 spectrin repeat containing, nuclear envelope 1 0.142859
SEBOX SEBOX homeobox 0.142835
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.14283
LGALS9 lectin, galactoside-binding, soluble, 9 0.142698
NRCAM neuronal cell adhesion molecule 0.142678
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.14258
AHSG alpha-2-HS-glycoprotein 0.142012
MGP matrix Gla protein 0.14073
IL1RN interleukin 1 receptor antagonist 0.140371
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.140334
S100A12 S100 calcium binding protein A12 0.139661
HSF4 heat shock transcription factor 4 0.139372
IL21 interleukin 21 0.139362
CD69 CD69 molecule 0.139273
FBXO32 F-box protein 32 0.138015
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.136531
ATG5 autophagy related 5 0.135846
BCL2 B-cell CLL/lymphoma 2 0.135567