dermatomyositis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A myositis and is_a dermatitis that results_in inflammation located_in muscle and located_in skin. The disease may result from either a viral infection or an autoimmune reaction.|A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6) (Experimental Factor Ontology, EFO_0000398)
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Genes

53 genes co-occuring with the biological term dermatomyositis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
ANGPTL2 angiopoietin-like 2
CCL17 chemokine (C-C motif) ligand 17
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CD28 CD28 molecule
CD44 CD44 molecule (Indian blood group)
CD83 CD83 molecule
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ESR1 estrogen receptor 1
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IL10 interleukin 10
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL22 interleukin 22
IL27 interleukin 27
IL33 interleukin 33
IL33R interleukin 33 receptor
IL6 interleukin 6
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR126 microRNA 126
MIR206 microRNA 206
MIR21 microRNA 21
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MORC3 MORC family CW-type zinc finger 3
SAE1 SUMO1 activating enzyme subunit 1
SPP1 secreted phosphoprotein 1
TGM2 transglutaminase 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRIM28 tripartite motif containing 28
TRIM33 tripartite motif containing 33
UBA2 ubiquitin-like modifier activating enzyme 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A