desipramine-1596 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the desipramine-1596 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMBRA1 autophagy/beclin-1 regulator 1
ANXA2P2 annexin A2 pseudogene 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BBIP1 BBSome interacting protein 1
BCAN brevican
BCLAF1 BCL2-associated transcription factor 1
BMP2K BMP2 inducible kinase
BPI bactericidal/permeability-increasing protein
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAPN10 calpain 10
CCL20 chemokine (C-C motif) ligand 20
CD2AP CD2-associated protein
CDCA3 cell division cycle associated 3
CDK13 cyclin-dependent kinase 13
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHMP1A charged multivesicular body protein 1A
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CIZ1 CDKN1A interacting zinc finger protein 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CTTN cortactin
CYB561 cytochrome b561
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGCR8 DGCR8 microprocessor complex subunit
DLC1 DLC1 Rho GTPase activating protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK5 dedicator of cytokinesis 5
EHBP1 EH domain binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FAM192A family with sequence similarity 192, member A
FN1 fibronectin 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GMPPB GDP-mannose pyrophosphorylase B
GOLM1 golgi membrane protein 1
GPR183 G protein-coupled receptor 183
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BF histone cluster 1, H2bf
JUN jun proto-oncogene
KLF9 Kruppel-like factor 9
KRT10 keratin 10, type I
MAML3 mastermind-like 3 (Drosophila)
MAP4 microtubule-associated protein 4
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBNL2 muscleblind-like splicing regulator 2
MICALL1 MICAL-like 1
MSH3 mutS homolog 3
MT1HL1 metallothionein 1H-like 1
MYL10 myosin, light chain 10, regulatory
NDRG3 NDRG family member 3
NELL2 NEL-like 2 (chicken)
PDS5A PDS5 cohesin associated factor A
PER2 period circadian clock 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKN1 protein kinase N1
PKP3 plakophilin 3
PLCD1 phospholipase C, delta 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRRC1 proline-rich coiled-coil 1
PTMA prothymosin, alpha
RAB11B RAB11B, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RP2 retinitis pigmentosa 2 (X-linked recessive)
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SETD1B SET domain containing 1B
SIDT2 SID1 transmembrane family, member 2
SKI SKI proto-oncogene
SOD3 superoxide dismutase 3, extracellular
SPN sialophorin
STK19 serine/threonine kinase 19
SUGP1 SURP and G patch domain containing 1
SZRD1 SUZ RNA binding domain containing 1
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TDRD3 tudor domain containing 3
THTPA thiamine triphosphatase
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMEM184C transmembrane protein 184C
TTC3 tetratricopeptide repeat domain 3
TULP3 tubby like protein 3
USO1 USO1 vesicle transport factor
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WDR45 WD repeat domain 45
YIPF2 Yip1 domain family, member 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF280D zinc finger protein 280D
ZNF609 zinc finger protein 609
ZNF652 zinc finger protein 652
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ACOT8 acyl-CoA thioesterase 8
ACP2 acid phosphatase 2, lysosomal
ACTN4 actinin, alpha 4
ACVR2B activin A receptor, type IIB
ADGRE5 adhesion G protein-coupled receptor E5
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ANAPC2 anaphase promoting complex subunit 2
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASAP1-IT1 ASAP1 intronic transcript 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBC3 BCL2 binding component 3
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BCL7C B-cell CLL/lymphoma 7C
BTBD3 BTB (POZ) domain containing 3
C19ORF40 chromosome 19 open reading frame 40
C1ORF35 chromosome 1 open reading frame 35
C8ORF44 chromosome 8 open reading frame 44
CABIN1 calcineurin binding protein 1
CCP110 centriolar coiled coil protein 110kDa
CD38 CD38 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP85 centrosomal protein 85kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIR1 corepressor interacting with RBPJ, 1
CLDN15 claudin 15
CLTCL1 clathrin, heavy chain-like 1
CTAGE9 CTAGE family, member 9
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DEAF1 DEAF1 transcription factor
ECM1 extracellular matrix protein 1
EDAR ectodysplasin A receptor
ELMO1 engulfment and cell motility 1
FAM134C family with sequence similarity 134, member C
FGR FGR proto-oncogene, Src family tyrosine kinase
FTO fat mass and obesity associated
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDAP2 ganglioside induced differentiation associated protein 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPATCH2 G patch domain containing 2
GPR63 G protein-coupled receptor 63
GRAMD1B GRAM domain containing 1B
GSTCD glutathione S-transferase, C-terminal domain containing
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
IDO1 indoleamine 2,3-dioxygenase 1
KCTD3 potassium channel tetramerization domain containing 3
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MGLL monoglyceride lipase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MON1B MON1 secretory trafficking family member B
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOD1 nucleotide-binding oligomerization domain containing 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
ORC3 origin recognition complex, subunit 3
PARP16 poly (ADP-ribose) polymerase family, member 16
PNKP polynucleotide kinase 3'-phosphatase
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPIEL peptidylprolyl isomerase E-like pseudogene
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RBBP5 retinoblastoma binding protein 5
RCL1 RNA terminal phosphate cyclase-like 1
RIC8A RIC8 guanine nucleotide exchange factor A
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGA Ras-related GTP binding A
RRP1 ribosomal RNA processing 1
RSF1 remodeling and spacing factor 1
RTN3 reticulon 3
RWDD2B RWD domain containing 2B
SASH3 SAM and SH3 domain containing 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC22A18 solute carrier family 22, member 18
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TAOK1 TAO kinase 1
THAP7 THAP domain containing 7
TMEM115 transmembrane protein 115
TMPRSS6 transmembrane protease, serine 6
TP53BP1 tumor protein p53 binding protein 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCKL1 uridine-cytidine kinase 1-like 1
USB1 U6 snRNA biogenesis 1
WBSCR16 Williams-Beuren syndrome chromosome region 16
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF282 zinc finger protein 282
ZNF629 zinc finger protein 629
ZSCAN5A zinc finger and SCAN domain containing 5A
ZSCAN9 zinc finger and SCAN domain containing 9