desipramine-6693 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the desipramine-6693 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADAP1 ArfGAP with dual PH domains 1
ADGB androglobin
ALDOB aldolase B, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CABP2 calcium binding protein 2
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNO cyclin O
CDC14A cell division cycle 14A
CNOT4 CCR4-NOT transcription complex, subunit 4
CSF1 colony stimulating factor 1 (macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTH cystathionine gamma-lyase
CTNND2 catenin (cadherin-associated protein), delta 2
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
CXXC4 CXXC finger protein 4
DCLK2 doublecortin-like kinase 2
DDIT3 DNA-damage-inducible transcript 3
DENND3 DENN/MADD domain containing 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EFNA3 ephrin-A3
ESR2 estrogen receptor 2 (ER beta)
EXO5 exonuclease 5
GAN gigaxonin
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GK3P glycerol kinase 3 pseudogene
GLI2 GLI family zinc finger 2
GPR1 G protein-coupled receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIPK3 homeodomain interacting protein kinase 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ICOS inducible T-cell co-stimulator
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INSIG1 insulin induced gene 1
IQCK IQ motif containing K
JUND jun D proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KIAA1467 KIAA1467
KLF4 Kruppel-like factor 4 (gut)
LIG3 ligase III, DNA, ATP-dependent
LIPG lipase, endothelial
LY6G6C lymphocyte antigen 6 complex, locus G6C
MDM4 MDM4, p53 regulator
MFAP3L microfibrillar-associated protein 3-like
MMP13 matrix metallopeptidase 13
MSX2 msh homeobox 2
MX1 MX dynamin-like GTPase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PADI1 peptidyl arginine deiminase, type I
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARK2 parkin RBR E3 ubiquitin protein ligase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM10 PR domain containing 10
PRKCE protein kinase C, epsilon
PVR poliovirus receptor
QKI QKI, KH domain containing, RNA binding
RAB6A RAB6A, member RAS oncogene family
RARG retinoic acid receptor, gamma
REPS1 RALBP1 associated Eps domain containing 1
RGS4 regulator of G-protein signaling 4
RNASE4 ribonuclease, RNase A family, 4
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
RYR1 ryanodine receptor 1 (skeletal)
SAMD4A sterile alpha motif domain containing 4A
SCARB2 scavenger receptor class B, member 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOS2 son of sevenless homolog 2 (Drosophila)
SPTB spectrin, beta, erythrocytic
SRRT serrate, RNA effector molecule
STK3 serine/threonine kinase 3
SYT1 synaptotagmin I
TGFB2 transforming growth factor, beta 2
TLX2 T-cell leukemia homeobox 2
TMPRSS2 transmembrane protease, serine 2
TRIB3 tribbles pseudokinase 3
TRIM3 tripartite motif containing 3
UPK3B uroplakin 3B
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF500 zinc finger protein 500
ZNF518A zinc finger protein 518A
ZNF589 zinc finger protein 589
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AEN apoptosis enhancing nuclease
ANOS1 anosmin 1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARL14 ADP-ribosylation factor-like 14
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX4 armadillo repeat containing, X-linked 4
ATAD5 ATPase family, AAA domain containing 5
ATAT1 alpha tubulin acetyltransferase 1
AXIN1 axin 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP15 bone morphogenetic protein 15
BTC betacellulin
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF93 chromosome 14 open reading frame 93
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCL27 chemokine (C-C motif) ligand 27
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH7 cadherin 7, type 2
CEMIP cell migration inducing protein, hyaluronan binding
CLDN8 claudin 8
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CYB5R2 cytochrome b5 reductase 2
DCLRE1B DNA cross-link repair 1B
DDN dendrin
DENND5B DENN/MADD domain containing 5B
E2F8 E2F transcription factor 8
ELSPBP1 epididymal sperm binding protein 1
ENDOG endonuclease G
ETNK2 ethanolamine kinase 2
FAM53B family with sequence similarity 53, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLJ21369 uncharacterized protein FLJ21369
GALK1 galactokinase 1
GPNMB glycoprotein (transmembrane) nmb
GRIP2 glutamate receptor interacting protein 2
GSTA3 glutathione S-transferase alpha 3
HIST1H2AM histone cluster 1, H2am
HIST1H3I histone cluster 1, H3i
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA7 homeobox A7
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3IP1 immediate early response 3 interacting protein 1
IQSEC2 IQ motif and Sec7 domain 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIRREL kin of IRRE like (Drosophila)
KRT75 keratin 75, type II
KRT9 keratin 9, type I
LINC00115 long intergenic non-protein coding RNA 115
LOC257152 uncharacterized LOC257152
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD3 LY6/PLAUR domain containing 3
MMP9 matrix metallopeptidase 9
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL41 mitochondrial ribosomal protein L41
MRPL52 mitochondrial ribosomal protein L52
MUC3A mucin 3A, cell surface associated
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NABP1 nucleic acid binding protein 1
NDE1 nudE neurodevelopment protein 1
NPM3 nucleophosmin/nucleoplasmin 3
NRTN neurturin
ORC1 origin recognition complex, subunit 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PALMD palmdelphin
PDE8B phosphodiesterase 8B
PLA2G15 phospholipase A2, group XV
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAG1 pleiomorphic adenoma gene 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PRR15L proline rich 15-like
RAI2 retinoic acid induced 2
RGS19 regulator of G-protein signaling 19
RHOBTB1 Rho-related BTB domain containing 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TM6SF1 transmembrane 6 superfamily member 1
TMCC2 transmembrane and coiled-coil domain family 2
TMEM121 transmembrane protein 121
TMEM132A transmembrane protein 132A
TMEM8B transmembrane protein 8B
ZNF230 zinc finger protein 230
ZNF239 zinc finger protein 239
ZNF408 zinc finger protein 408
ZNF492 zinc finger protein 492
ZNF770 zinc finger protein 770
ZNF813 zinc finger protein 813