| Dataset | CTD Gene-Chemical Interactions |
| Category | physical interactions |
| Type | chemical |
| Description | Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. (Chemical Entities of Biological Interest Ontology, CHEBI_291342) |
| External Link | http://ctdbase.org/detail.go?type=chem&acc=C121345 |
| Similar Terms | |
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7 genes/proteins interacting with the chemical desloratadine from the curated CTD Gene-Chemical Interactions dataset.
| Symbol | Name |
|---|---|
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CYP2D6 | cytochrome P450, family 2, subfamily D, polypeptide 6 |
| HRH1 | histamine receptor H1 |
| IL5 | interleukin 5 |
| SLC22A2 | solute carrier family 22 (organic cation transporter), member 2 |
