A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. (Gene Ontology, GO_0030057)
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19 proteins localized to the desmosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
