destruction Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

269 genes co-occuring with the biological term destruction in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACP5 acid phosphatase 5, tartrate resistant
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AGTRAP angiotensin II receptor-associated protein
AIRE autoimmune regulator
AMER1 APC membrane recruitment protein 1
ANAPC10 anaphase promoting complex subunit 10
ANXA2 annexin A2
APC adenomatous polyposis coli
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AXIN1 axin 1
BAX BCL2-associated X protein
BDNF brain-derived neurotrophic factor
BSG basigin (Ok blood group)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CABIN1 calcineurin binding protein 1
CACYBP calcyclin binding protein
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD151 CD151 molecule (Raph blood group)
CD28 CD28 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD47 CD47 molecule
CD70 CD70 molecule
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC25A cell division cycle 25A
CDC27 cell division cycle 27
CDC6 cell division cycle 6
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDT1 chromatin licensing and DNA replication factor 1
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
COL18A1 collagen, type XVIII, alpha 1
COL2A1 collagen, type II, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSNK1A1 casein kinase 1, alpha 1
CTSB cathepsin B
CTSG cathepsin G
CTSL cathepsin L
CUEDC2 CUE domain containing 2
CUL1 cullin 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DDR2 discoidin domain receptor tyrosine kinase 2
DEFA1 defensin, alpha 1
DEPTOR DEP domain containing MTOR-interacting protein
DIABLO diablo, IAP-binding mitochondrial protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP9 dipeptidyl-peptidase 9
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
ELN elastin
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FBLN5 fibulin 5
FBXO5 F-box protein 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
FCRL3 Fc receptor-like 3
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GLI2 GLI family zinc finger 2
GLRX2 glutaredoxin 2
GLS glutaminase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPX1 glutathione peroxidase 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM2 glutamate receptor, metabotropic 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HP haptoglobin
HPSE heparanase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HTRA1 HtrA serine peptidase 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDE insulin-degrading enzyme
IFNG interferon, gamma
IGFBP3 insulin-like growth factor binding protein 3
IL15 interleukin 15
IL16 interleukin 16
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL27 interleukin 27
IL3 interleukin 3
IL6 interleukin 6
IL7 interleukin 7
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAM3 junctional adhesion molecule 3
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KREMEN1 kringle containing transmembrane protein 1
LEP leptin
LEPR leptin receptor
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
MAG myelin associated glycoprotein
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK8 mitogen-activated protein kinase 8
MARVELD2 MARVEL domain containing 2
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR18A microRNA 18a
MIR223 microRNA 223
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MRC2 mannose receptor, C type 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NDRG2 NDRG family member 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOD2 nucleotide-binding oligomerization domain containing 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ORC1 origin recognition complex, subunit 1
OSM oncostatin M
PAX2 paired box 2
PCNA proliferating cell nuclear antigen
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLEC plectin
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PPL periplakin
PRF1 perforin 1 (pore forming protein)
PRKCZ protein kinase C, zeta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RHOBTB2 Rho-related BTB domain containing 2
RICTOR RPTOR independent companion of MTOR, complex 2
S100A8 S100 calcium binding protein A8
SAA1 serum amyloid A1
SALL2 spalt-like transcription factor 2
SAMHD1 SAM domain and HD domain 1
SDC1 syndecan 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIRPA signal-regulatory protein alpha
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLAMF7 SLAM family member 7
SMAD4 SMAD family member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SOST sclerostin
SPAG16 sperm associated antigen 16
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TALDO1 transaldolase 1
TERT telomerase reverse transcriptase
TF transferrin
TFF1 trefoil factor 1
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNC tenascin C
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TOP2A topoisomerase (DNA) II alpha 170kDa
TPO thyroid peroxidase
TRAF1 TNF receptor-associated factor 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRRAP transformation/transcription domain-associated protein
TSC2 tuberous sclerosis 2
TUBB4A tubulin, beta 4A class IVa
USP37 ubiquitin specific peptidase 37
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WEE1 WEE1 G2 checkpoint kinase
WNT3A wingless-type MMTV integration site family, member 3A
WNT7A wingless-type MMTV integration site family, member 7A
ZDHHC9 zinc finger, DHHC-type containing 9