dexamethasone-123 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the dexamethasone-123 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
ACTC1 actin, alpha, cardiac muscle 1
ACVR1B activin A receptor, type IB
AFF2 AF4/FMR2 family, member 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARNT aryl hydrocarbon receptor nuclear translocator
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
AVL9 AVL9 homolog (S. cerevisiase)
B3GAT3 beta-1,3-glucuronyltransferase 3
BAIAP3 BAI1-associated protein 3
BCL6 B-cell CLL/lymphoma 6
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C21ORF2 chromosome 21 open reading frame 2
C22ORF29 chromosome 22 open reading frame 29
CCNL2 cyclin L2
CD44 CD44 molecule (Indian blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLCN7 chloride channel, voltage-sensitive 7
CLTA clathrin, light chain A
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGCR2 DiGeorge syndrome critical region gene 2
DMTN dematin actin binding protein
DND1 DND microRNA-mediated repression inhibitor 1
DTNA dystrobrevin, alpha
DUS2 dihydrouridine synthase 2
DXO decapping exoribonuclease
E2F3 E2F transcription factor 3
EFNB3 ephrin-B3
EGR3 early growth response 3
EHBP1 EH domain binding protein 1
EPS8L1 EPS8-like 1
EVPL envoplakin
EXOC3 exocyst complex component 3
FAM153A family with sequence similarity 153, member A
FAM86C1 family with sequence similarity 86, member C1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
GANAB glucosidase, alpha; neutral AB
GPSM3 G-protein signaling modulator 3
GPX2 glutathione peroxidase 2
GREB1L growth regulation by estrogen in breast cancer-like
HAMP hepcidin antimicrobial peptide
HIST3H2A histone cluster 3, H2a
HOXC11 homeobox C11
HPS1 Hermansky-Pudlak syndrome 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPP5K inositol polyphosphate-5-phosphatase K
JOSD1 Josephin domain containing 1
KAZN kazrin, periplakin interacting protein
KCTD2 potassium channel tetramerization domain containing 2
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LRP5 low density lipoprotein receptor-related protein 5
MAN2B2 mannosidase, alpha, class 2B, member 2
MAP4 microtubule-associated protein 4
MAP7D3 MAP7 domain containing 3
MED9 mediator complex subunit 9
MOB3B MOB kinase activator 3B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MT1HL1 metallothionein 1H-like 1
MYL10 myosin, light chain 10, regulatory
MYO9B myosin IXB
MYOF myoferlin
NIPAL2 NIPA-like domain containing 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLSCR3 phospholipid scramblase 3
PRB4 proline-rich protein BstNI subfamily 4
PRRC2A proline-rich coiled-coil 2A
PVT1 Pvt1 oncogene (non-protein coding)
RALGDS ral guanine nucleotide dissociation stimulator
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBKS ribokinase
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC41A3 solute carrier family 41, member 3
SMO smoothened, frizzled class receptor
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPTBN5 spectrin, beta, non-erythrocytic 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK19 serine/threonine kinase 19
SYF2 SYF2 pre-mRNA-splicing factor
TBX21 T-box 21
TEFM transcription elongation factor, mitochondrial
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM74B transmembrane protein 74B
TMEM80 transmembrane protein 80
TREX1 three prime repair exonuclease 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR61 WD repeat domain 61
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB22 zinc finger and BTB domain containing 22
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF136 zinc finger protein 136

decreased expression

Symbol Name
AGO1 argonaute RISC catalytic component 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGAP10 Rho GTPase activating protein 10
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AXIN1 axin 1
C17ORF85 chromosome 17 open reading frame 85
CD248 CD248 molecule, endosialin
CD48 CD48 molecule
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEP192 centrosomal protein 192kDa
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNTD2 cyclin N-terminal domain containing 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUZD1 CUB and zona pellucida-like domains 1
DAGLA diacylglycerol lipase, alpha
DHDDS dehydrodolichyl diphosphate synthase
DMBT1 deleted in malignant brain tumors 1
DPH2 DPH2 homolog (S. cerevisiae)
EGLN1 egl-9 family hypoxia-inducible factor 1
EHD4 EH-domain containing 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FBXO31 F-box protein 31
FGF6 fibroblast growth factor 6
FKBP6 FK506 binding protein 6, 36kDa
FOXI1 forkhead box I1
FUZ fuzzy planar cell polarity protein
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GDF3 growth differentiation factor 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
HDAC7 histone deacetylase 7
HOXB2 homeobox B2
HPS5 Hermansky-Pudlak syndrome 5
IL15RA interleukin 15 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4R interleukin 4 receptor
INTS8 integrator complex subunit 8
KDM7A lysine (K)-specific demethylase 7A
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEFTY1 left-right determination factor 1
LMTK1 lemur tail kinase 1
MACROD1 MACRO domain containing 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK3 mitogen-activated protein kinase 3
MATK megakaryocyte-associated tyrosine kinase
MFSD12 major facilitator superfamily domain containing 12
MIR22HG MIR22 host gene
MYO1A myosin IA
NARF nuclear prelamin A recognition factor
NEMF nuclear export mediator factor
NUP153 nucleoporin 153kDa
OR1F1 olfactory receptor, family 1, subfamily F, member 1
OVOL1 ovo-like zinc finger 1
OXR1 oxidation resistance 1
PAQR4 progestin and adipoQ receptor family member IV
PEMT phosphatidylethanolamine N-methyltransferase
PGP phosphoglycolate phosphatase
PLCD1 phospholipase C, delta 1
PLXNB3 plexin B3
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPOX protoporphyrinogen oxidase
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRODH2 proline dehydrogenase (oxidase) 2
RAD54L RAD54-like (S. cerevisiae)
REEP4 receptor accessory protein 4
RPL39L ribosomal protein L39-like
RPS17P5 ribosomal protein S17 pseudogene 5
SCD5 stearoyl-CoA desaturase 5
SERINC5 serine incorporator 5
SH2D4A SH2 domain containing 4A
SIL1 SIL1 nucleotide exchange factor
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SOBP sine oculis binding protein homolog (Drosophila)
SPDL1 spindle apparatus coiled-coil protein 1
SPIDR scaffolding protein involved in DNA repair
SQRDL sulfide quinone reductase-like (yeast)
SRBD1 S1 RNA binding domain 1
STAT4 signal transducer and activator of transcription 4
SUSD4 sushi domain containing 4
TBPL1 TBP-like 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TIPRL TOR signaling pathway regulator
TMEM40 transmembrane protein 40
TMOD3 tropomodulin 3 (ubiquitous)
TTF2 transcription termination factor, RNA polymerase II
TUBA3D tubulin, alpha 3d
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UBQLN4 ubiquilin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
VRK2 vaccinia related kinase 2
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
ZBTB24 zinc finger and BTB domain containing 24
ZHX2 zinc fingers and homeoboxes 2
ZNF552 zinc finger protein 552