dexibuprofen-3094 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the dexibuprofen-3094 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BRS3 bombesin-like receptor 3
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CD47 CD47 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
COL7A1 collagen, type VII, alpha 1
DESI2 desumoylating isopeptidase 2
DICER1 dicer 1, ribonuclease type III
DLG4 discs, large homolog 4 (Drosophila)
DMP1 dentin matrix acidic phosphoprotein 1
DNAI2 dynein, axonemal, intermediate chain 2
DPEP2 dipeptidase 2
DVL2 dishevelled segment polarity protein 2
EEA1 early endosome antigen 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM46C family with sequence similarity 46, member C
FAM65A family with sequence similarity 65, member A
FAS Fas cell surface death receptor
FASTK Fas-activated serine/threonine kinase
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FCF1 FCF1 rRNA-processing protein
FOXO1 forkhead box O1
FST follistatin
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAREM GRB2 associated, regulator of MAPK1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLCE glucuronic acid epimerase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPX2 glutathione peroxidase 2
IFITM1 interferon induced transmembrane protein 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM4C lysine (K)-specific demethylase 4C
KHK ketohexokinase (fructokinase)
KRT8P12 keratin 8 pseudogene 12
LDB1 LIM domain binding 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP4 latent transforming growth factor beta binding protein 4
MAST2 microtubule associated serine/threonine kinase 2
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MNMIP1 manchette microtubule inner protein 1
MPZL1 myelin protein zero-like 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYO1B myosin IB
NCAPH2 non-SMC condensin II complex, subunit H2
NENF neudesin neurotrophic factor
NPHP1 nephronophthisis 1 (juvenile)
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFML2A olfactomedin-like 2A
PENK proenkephalin
PIGR polymeric immunoglobulin receptor
PLCL2 phospholipase C-like 2
PNPLA4 patatin-like phospholipase domain containing 4
POU2F2 POU class 2 homeobox 2
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRB3 proline-rich protein BstNI subfamily 3
PRKY protein kinase, Y-linked, pseudogene
PURG purine-rich element binding protein G
PVR poliovirus receptor
RAP1GAP2 RAP1 GTPase activating protein 2
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RELN reelin
RPL35A ribosomal protein L35a
RPL7 ribosomal protein L7
RPS28 ribosomal protein S28
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMTN smoothelin
SNTG1 syntrophin, gamma 1
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
TBCD tubulin folding cofactor D
TCAF1 TRPM8 channel-associated factor 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THRB thyroid hormone receptor, beta
TIMP2 TIMP metallopeptidase inhibitor 2
TLDC1 TBC/LysM-associated domain containing 1
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TRIM3 tripartite motif containing 3
VSNL1 visinin-like 1
XYLB xylulokinase homolog (H. influenzae)
ZC3H13 zinc finger CCCH-type containing 13
ZNF235 zinc finger protein 235
ZNF528 zinc finger protein 528

decreased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ANO10 anoctamin 10
ANXA2P3 annexin A2 pseudogene 3
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BEND5 BEN domain containing 5
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF95 chromosome 11 open reading frame 95
C5AR1 complement component 5a receptor 1
CCDC106 coiled-coil domain containing 106
CDO1 cysteine dioxygenase type 1
CEP170B centrosomal protein 170B
CEP97 centrosomal protein 97kDa
CFAP69 cilia and flagella associated protein 69
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLCA1 chloride channel accessory 1
CNPY4 canopy FGF signaling regulator 4
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRYL1 crystallin, lambda 1
CXORF56 chromosome X open reading frame 56
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DUSP8 dual specificity phosphatase 8
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
FAM13C family with sequence similarity 13, member C
FBXL6 F-box and leucine-rich repeat protein 6
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCHO1 FCH domain only 1
FES FES proto-oncogene, tyrosine kinase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR27 G protein-coupled receptor 27
GPR35 G protein-coupled receptor 35
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HDAC7 histone deacetylase 7
HIST1H4E histone cluster 1, H4e
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IFNA14 interferon, alpha 14
IL12RB1 interleukin 12 receptor, beta 1
IL2 interleukin 2
IRS1 insulin receptor substrate 1
JAM2 junctional adhesion molecule 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF24 kinesin family member 24
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LOC100286895 cell division cycle 27 homolog pseudogene
LOC730101 uncharacterized LOC730101
LOXL3 lysyl oxidase-like 3
LPPR1 lipid phosphate phosphatase-related protein type 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP1S microtubule-associated protein 1S
MDFI MyoD family inhibitor
MYL5 myosin, light chain 5, regulatory
NDE1 nudE neurodevelopment protein 1
NEUROD4 neuronal differentiation 4
NOD2 nucleotide-binding oligomerization domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDGFD platelet derived growth factor D
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POR P450 (cytochrome) oxidoreductase
POU5F1B POU class 5 homeobox 1B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROL1 proline rich, lacrimal 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAB17 RAB17, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
SETBP1 SET binding protein 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLITRK5 SLIT and NTRK-like family, member 5
SOX12 SRY (sex determining region Y)-box 12
SPHK1 sphingosine kinase 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TIAM2 T-cell lymphoma invasion and metastasis 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMC5 transmembrane channel-like 5
TMEM120B transmembrane protein 120B
TMEM180 transmembrane protein 180
TMEM246 transmembrane protein 246
TMEM53 transmembrane protein 53
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
UNC119 unc-119 homolog (C. elegans)
VEZT vezatin, adherens junctions transmembrane protein
WASF3 WAS protein family, member 3
YY2 YY2 transcription factor
ZC3H3 zinc finger CCCH-type containing 3
ZNF862 zinc finger protein 862