dexibuprofen-6712 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the dexibuprofen-6712 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACOT11 acyl-CoA thioesterase 11
ADGB androglobin
APOB apolipoprotein B
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP9A ATPase, class II, type 9A
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C10ORF12 chromosome 10 open reading frame 12
CARTPT CART prepropeptide
CISH cytokine inducible SH2-containing protein
CNGB3 cyclic nucleotide gated channel beta 3
CTNS cystinosin, lysosomal cystine transporter
DAPK2 death-associated protein kinase 2
DUOX2 dual oxidase 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFCAB11 EF-hand calcium binding domain 11
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPHA3 EPH receptor A3
FAM149A family with sequence similarity 149, member A
FRMD4B FERM domain containing 4B
FUBP1 far upstream element (FUSE) binding protein 1
GH1 growth hormone 1
GIMAP5 GTPase, IMAP family member 5
GJA3 gap junction protein, alpha 3, 46kDa
GLP1R glucagon-like peptide 1 receptor
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM4 glutamate receptor, metabotropic 4
GSN-AS1 GSN antisense RNA 1
H2AFX H2A histone family, member X
HLA-DOA major histocompatibility complex, class II, DO alpha
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRS4 insulin receptor substrate 4
JPH3 junctophilin 3
KIF25 kinesin family member 25
KLHL23 kelch-like family member 23
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LMOD1 leiomodin 1 (smooth muscle)
LRRK1 leucine-rich repeat kinase 1
LRRN3 leucine rich repeat neuronal 3
MBD2 methyl-CpG binding domain protein 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MNMIP1 manchette microtubule inner protein 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYEF2 myelin expression factor 2
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NRG1 neuregulin 1
OAZ3 ornithine decarboxylase antizyme 3
PAX2 paired box 2
PAX8 paired box 8
PGLYRP4 peptidoglycan recognition protein 4
PITX1 paired-like homeodomain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G3 phospholipase A2, group III
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
PP14571 uncharacterized LOC100130449
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKG1 protein kinase, cGMP-dependent, type I
PTCH1 patched 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RIC3 RIC3 acetylcholine receptor chaperone
RPL14 ribosomal protein L14
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RRAGD Ras-related GTP binding D
RS1 retinoschisin 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC17A4 solute carrier family 17, member 4
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX21 SRY (sex determining region Y)-box 21
SOX5 SRY (sex determining region Y)-box 5
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SYCE1L synaptonemal complex central element protein 1-like
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THBD thrombomodulin
TMPRSS4 transmembrane protease, serine 4
TPM1 tropomyosin 1 (alpha)
TRIM49 tripartite motif containing 49
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TSPY1 testis specific protein, Y-linked 1
TYMP thymidine phosphorylase
UBE2I ubiquitin-conjugating enzyme E2I
VASH1 vasohibin 1
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
WDR78 WD repeat domain 78
ZBTB7A zinc finger and BTB domain containing 7A
ZNF140 zinc finger protein 140
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADAM15 ADAM metallopeptidase domain 15
AFAP1 actin filament associated protein 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB2 arrestin, beta 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AXIN1 axin 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD70 CD70 molecule
CLDN4 claudin 4
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CORO1A coronin, actin binding protein, 1A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDA1 DET1 and DDB1 associated 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
EMP3 epithelial membrane protein 3
EPN3 epsin 3
EXOSC5 exosome component 5
FAM168B family with sequence similarity 168, member B
FBXL6 F-box and leucine-rich repeat protein 6
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDAP1 ganglioside induced differentiation associated protein 1
GJC1 gap junction protein, gamma 1, 45kDa
GLT8D2 glycosyltransferase 8 domain containing 2
GPATCH2L G patch domain containing 2-like
GPR176 G protein-coupled receptor 176
GTF2I general transcription factor IIi
H2BFS H2B histone family, member S (pseudogene)
HDAC5 histone deacetylase 5
HIRIP3 HIRA interacting protein 3
HIST1H3A histone cluster 1, H3a
HIST1H4E histone cluster 1, H4e
HP1BP3 heterochromatin protein 1, binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
KRT75 keratin 75, type II
KRT8P12 keratin 8 pseudogene 12
LMO7 LIM domain 7
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAPK3 mitogen-activated protein kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECR mitochondrial trans-2-enoyl-CoA reductase
MED18 mediator complex subunit 18
MOB3B MOB kinase activator 3B
MOCS3 molybdenum cofactor synthesis 3
MXD3 MAX dimerization protein 3
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NOTCH1 notch 1
NUPR1 nuclear protein, transcriptional regulator, 1
PARD6A par-6 family cell polarity regulator alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PECR peroxisomal trans-2-enoyl-CoA reductase
PIAS3 protein inhibitor of activated STAT, 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLM polymerase (DNA directed), mu
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PROSER1 proline and serine rich 1
PRPH peripherin
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RNF146 ring finger protein 146
RPL11 ribosomal protein L11
S100A4 S100 calcium binding protein A4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC35F6 solute carrier family 35, member F6
SMG9 SMG9 nonsense mediated mRNA decay factor
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG7 sperm associated antigen 7
SPTBN2 spectrin, beta, non-erythrocytic 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STRN striatin, calmodulin binding protein
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRAPPC2L trafficking protein particle complex 2-like
TSPAN1 tetraspanin 1
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TXLNG taxilin gamma
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR18 WD repeat domain 18
WDR19 WD repeat domain 19
WDR76 WD repeat domain 76
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF667 zinc finger protein 667
ZNF711 zinc finger protein 711