diabetes Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.|A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE. (Experimental Factor Ontology, EFO_0000400)
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Genes

119 proteins co-occuring with the biological term diabetes in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AQP2 aquaporin 2 (collecting duct)
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BAD BCL2-associated agonist of cell death
BRSK2 BR serine/threonine kinase 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CDK5 cyclin-dependent kinase 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CREB1 cAMP responsive element binding protein 1
CRTC2 CREB regulated transcription coactivator 2
CSNK1E casein kinase 1, epsilon
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DNM1L dynamin 1-like
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRK fyn-related Src family tyrosine kinase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB14 growth factor receptor-bound protein 14
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HDAC5 histone deacetylase 5
HIST1H3A histone cluster 1, H3a
HIST2H3C histone cluster 2, H3c
HK2 hexokinase 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPK heterogeneous nuclear ribonucleoprotein K
IGF1R insulin-like growth factor 1 receptor
INSR insulin receptor
IPMK inositol polyphosphate multikinase
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LEPR leptin receptor
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
NEU3 sialidase 3 (membrane sialidase)
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSBP oxysterol binding protein
PACS2 phosphofurin acidic cluster sorting protein 2
PDX1 pancreatic and duodenal homeobox 1
PDZD11 PDZ domain containing 11
PEA15 phosphoprotein enriched in astrocytes 15
PLN phospholamban
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RYR2 ryanodine receptor 2 (cardiac)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK2 salt-inducible kinase 2
SIRT1 sirtuin 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMAD2 SMAD family member 2
SNAPIN SNAP-associated protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SRSF5 serine/arginine-rich splicing factor 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STK11 serine/threonine kinase 11
STXBP3 syntaxin binding protein 3
SYN1 synapsin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
UBTF upstream binding transcription factor, RNA polymerase I
ULK1 unc-51 like autophagy activating kinase 1
VASP vasodilator-stimulated phosphoprotein
XBP1 X-box binding protein 1