diarrhea Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. (Human Disease Ontology, DOID_13250)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005036
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Genes

33 gene mutations causing the diarrhea phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CCR2 chemokine (C-C motif) receptor 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPCAM epithelial cell adhesion molecule
FOXP3 forkhead box P3
GBP3 guanylate binding protein 3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GUCY2C guanylate cyclase 2C
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
KRT8 keratin 8, type II
LIF leukemia inhibitory factor
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MMP7 matrix metallopeptidase 7
MUC2 mucin 2, oligomeric mucus/gel-forming
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-3 NK2 homeobox 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RAB8A RAB8A, member RAS oncogene family
RELN reelin
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TSTA3 tissue specific transplantation antigen P35B