diazoxide-2052 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the diazoxide-2052 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
BICD1 bicaudal D homolog 1 (Drosophila)
BMP4 bone morphogenetic protein 4
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACYBP calcyclin binding protein
CAMKMT calmodulin-lysine N-methyltransferase
CAPN2 calpain 2, (m/II) large subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD101 CD101 molecule
CDC5L cell division cycle 5-like
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDRT1 CMT1A duplicated region transcript 1
CENPJ centromere protein J
CENPT centromere protein T
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CYHR1 cysteine/histidine-rich 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DHODH dihydroorotate dehydrogenase (quinone)
DSCR3 Down syndrome critical region 3
EDAR ectodysplasin A receptor
EGR2 early growth response 2
EHBP1 EH domain binding protein 1
EML2 echinoderm microtubule associated protein like 2
EPS8L1 EPS8-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAF2 Fas associated factor family member 2
FBXO21 F-box protein 21
FBXO38 F-box protein 38
FGF1 fibroblast growth factor 1 (acidic)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA2 forkhead box A2
GAL3ST4 galactose-3-O-sulfotransferase 4
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GTPBP6 GTP binding protein 6 (putative)
H2AFX H2A histone family, member X
HCRP1 hepatocellular carcinoma-related HCRP1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGL immunoglobulin lambda locus
IL6ST interleukin 6 signal transducer
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
LIME1 Lck interacting transmembrane adaptor 1
LINC00094 long intergenic non-protein coding RNA 94
LMO7 LIM domain 7
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAP4 microtubule-associated protein 4
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPI mannose phosphate isomerase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCKIPSD NCK interacting protein with SH3 domain
OLFM4 olfactomedin 4
ORC5 origin recognition complex, subunit 5
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PODXL2 podocalyxin-like 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOT2 ras homolog family member T2
RNF122 ring finger protein 122
RRAD Ras-related associated with diabetes
SAMD9 sterile alpha motif domain containing 9
SETD6 SET domain containing 6
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPB surfactant protein B
SIRT5 sirtuin 5
SIX3 SIX homeobox 3
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STK3 serine/threonine kinase 3
STXBP6 syntaxin binding protein 6 (amisyn)
SUGP1 SURP and G patch domain containing 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D2B TBC1 domain family, member 2B
TBX2 T-box 2
TCP11L1 t-complex 11, testis-specific-like 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNK1 tyrosine kinase, non-receptor, 1
TRIM9 tripartite motif containing 9
TUBD1 tubulin, delta 1
TUBG2 tubulin, gamma 2
UBQLN4 ubiquilin 4
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZFX zinc finger protein, X-linked
ZNF286A zinc finger protein 286A
ZNF385D zinc finger protein 385D
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANAPC2 anaphase promoting complex subunit 2
ANKRD36B ankyrin repeat domain 36B
ANXA2P3 annexin A2 pseudogene 3
APOO apolipoprotein O
ARHGAP12 Rho GTPase activating protein 12
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB2 arrestin, beta 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCAS4 breast carcinoma amplified sequence 4
BTBD2 BTB (POZ) domain containing 2
C1ORF56 chromosome 1 open reading frame 56
CBY1 chibby homolog 1 (Drosophila)
CCDC176 coiled-coil domain containing 176
CCDC68 coiled-coil domain containing 68
CCNT1 cyclin T1
CEP131 centrosomal protein 131kDa
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLIC3 chloride intracellular channel 3
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DDIT4 DNA-damage-inducible transcript 4
DEAF1 DEAF1 transcription factor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ELP3 elongator acetyltransferase complex subunit 3
EML4 echinoderm microtubule associated protein like 4
EMP3 epithelial membrane protein 3
ERF Ets2 repressor factor
FLCN folliculin
FPGS folylpolyglutamate synthase
FZD7 frizzled class receptor 7
GID4 GID complex subunit 4
GLI3 GLI family zinc finger 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRPR gastrin-releasing peptide receptor
HIRA histone cell cycle regulator
HOXA1 homeobox A1
HS1BP3 HCLS1 binding protein 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ICE2 interactor of little elongation complex ELL subunit 2
IRF1 interferon regulatory factor 1
KDM5C lysine (K)-specific demethylase 5C
KIFAP3 kinesin-associated protein 3
LOC100272216 uncharacterized LOC100272216
LPAR6 lysophosphatidic acid receptor 6
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCM3AP-AS1 MCM3AP antisense RNA 1
MED22 mediator complex subunit 22
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MOSPD3 motile sperm domain containing 3
NCS1 neuronal calcium sensor 1
NME6 NME/NM23 nucleoside diphosphate kinase 6
OLFML2A olfactomedin-like 2A
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARD6A par-6 family cell polarity regulator alpha
PARM1 prostate androgen-regulated mucin-like protein 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLCD1 phospholipase C, delta 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLI polymerase (DNA directed) iota
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTK6 protein tyrosine kinase 6
RAB33B RAB33B, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF25 ring finger protein 25
RPAP1 RNA polymerase II associated protein 1
SEPP1 selenoprotein P, plasma, 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX5 syntaxin 5
SYTL2 synaptotagmin-like 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TGFB3 transforming growth factor, beta 3
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMCC2 transmembrane and coiled-coil domain family 2
TRAPPC6A trafficking protein particle complex 6A
TRPM4 transient receptor potential cation channel, subfamily M, member 4
WDR76 WD repeat domain 76
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB48 zinc finger and BTB domain containing 48
ZFP36 ZFP36 ring finger protein
ZMAT5 zinc finger, matrin-type 5
ZMYM3 zinc finger, MYM-type 3
ZNF232 zinc finger protein 232
ZNF273 zinc finger protein 273
ZNF324 zinc finger protein 324
ZNF580 zinc finger protein 580
ZNF862 zinc finger protein 862