diazoxide-2214 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the diazoxide-2214 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOB aldolase B, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APAF1 apoptotic peptidase activating factor 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP11A ATPase, class VI, type 11A
C17ORF59 chromosome 17 open reading frame 59
C1QB complement component 1, q subcomponent, B chain
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDRT1 CMT1A duplicated region transcript 1
CFAP69 cilia and flagella associated protein 69
CHM choroideremia (Rab escort protein 1)
COL6A1 collagen, type VI, alpha 1
COMMD4 COMM domain containing 4
CRTC1 CREB regulated transcription coactivator 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGCR8 DGCR8 microprocessor complex subunit
DLX2 distal-less homeobox 2
DMBT1 deleted in malignant brain tumors 1
DOK2 docking protein 2, 56kDa
EPHA5 EPH receptor A5
ETV5 ets variant 5
FGF16 fibroblast growth factor 16
FH fumarate hydratase
FKRP fukutin related protein
FRMD1 FERM domain containing 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GIMAP6 GTPase, IMAP family member 6
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
ICOSLG inducible T-cell co-stimulator ligand
IPW imprinted in Prader-Willi syndrome (non-protein coding)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KMT2A lysine (K)-specific methyltransferase 2A
LARP7 La ribonucleoprotein domain family, member 7
LEFTY2 left-right determination factor 2
LPL lipoprotein lipase
MBNL2 muscleblind-like splicing regulator 2
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL10 myosin, light chain 10, regulatory
NF2 neurofibromin 2 (merlin)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NPAS3 neuronal PAS domain protein 3
NUP188 nucleoporin 188kDa
OCLM oculomedin
PCDHA5 protocadherin alpha 5
PCNX pecanex homolog (Drosophila)
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POU4F2 POU class 4 homeobox 2
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REPS1 RALBP1 associated Eps domain containing 1
RIF1 replication timing regulatory factor 1
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RPLP2 ribosomal protein, large, P2
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SH3BP2 SH3-domain binding protein 2
SIRPA signal-regulatory protein alpha
SIRT5 sirtuin 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMIM14 small integral membrane protein 14
SOAT2 sterol O-acyltransferase 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRY4 sprouty homolog 4 (Drosophila)
SRGN serglycin
STX2 syntaxin 2
STX7 syntaxin 7
TBL1Y transducin (beta)-like 1, Y-linked
TCF25 transcription factor 25 (basic helix-loop-helix)
TLR5 toll-like receptor 5
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TPSG1 tryptase gamma 1
TUBA3C tubulin, alpha 3c
TUBBP5 tubulin, beta pseudogene 5
USP46 ubiquitin specific peptidase 46
XYLB xylulokinase homolog (H. influenzae)
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AFAP1 actin filament associated protein 1
ARHGAP4 Rho GTPase activating protein 4
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C1ORF56 chromosome 1 open reading frame 56
C2ORF27A chromosome 2 open reading frame 27A
C7ORF43 chromosome 7 open reading frame 43
CCDC69 coiled-coil domain containing 69
CCDC71 coiled-coil domain containing 71
CD80 CD80 molecule
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CEMIP cell migration inducing protein, hyaluronan binding
CERS4 ceramide synthase 4
CHST10 carbohydrate sulfotransferase 10
CPPED1 calcineurin-like phosphoesterase domain containing 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DMTN dematin actin binding protein
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DTX2 deltex 2, E3 ubiquitin ligase
EXD3 exonuclease 3'-5' domain containing 3
FBXW12 F-box and WD repeat domain containing 12
FLCN folliculin
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GJA9 gap junction protein, alpha 9, 59kDa
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR157 G protein-coupled receptor 157
GPR21 G protein-coupled receptor 21
GRPR gastrin-releasing peptide receptor
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTPBP2 GTP binding protein 2
HIST1H2AK histone cluster 1, H2ak
HIST1H4D histone cluster 1, H4d
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA10 integrin, alpha 10
ITPKB inositol-trisphosphate 3-kinase B
KIAA0355 KIAA0355
KIF13B kinesin family member 13B
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
KRBOX4 KRAB box domain containing 4
LY6D lymphocyte antigen 6 complex, locus D
LY6G6C lymphocyte antigen 6 complex, locus G6C
MRPL41 mitochondrial ribosomal protein L41
MRPL52 mitochondrial ribosomal protein L52
MVP major vault protein
PAIP2B poly(A) binding protein interacting protein 2B
PICK1 protein interacting with PRKCA 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLD3 phospholipase D family, member 3
PODNL1 podocan-like 1
PRKCE protein kinase C, epsilon
RAB30 RAB30, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCAN3 RCAN family member 3
RIN2 Ras and Rab interactor 2
RNF170 ring finger protein 170
RNF2 ring finger protein 2
RNF208 ring finger protein 208
RPAP1 RNA polymerase II associated protein 1
SCAMP5 secretory carrier membrane protein 5
SDC3 syndecan 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD1A SET domain containing 1A
SIPA1 signal-induced proliferation-associated 1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SRPX sushi-repeat containing protein, X-linked
STARD3 StAR-related lipid transfer (START) domain containing 3
STIM1 stromal interaction molecule 1
TCTA T-cell leukemia translocation altered
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TLR2 toll-like receptor 2
TMEM104 transmembrane protein 104
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSPAN2 tetraspanin 2
TWF2 twinfilin actin binding protein 2
USB1 U6 snRNA biogenesis 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB48 zinc finger and BTB domain containing 48
ZIC3 Zic family member 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41
ZNF611 zinc finger protein 611
ZNF623 zinc finger protein 623
ZNF701 zinc finger protein 701
ZNF747 zinc finger protein 747