diazoxide-5810 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the diazoxide-5810 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGO4 argonaute RISC catalytic component 4
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANP32A-IT1 ANP32A intronic transcript 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARMC8 armadillo repeat containing 8
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BTC betacellulin
C1QTNF1 C1q and tumor necrosis factor related protein 1
CCP110 centriolar coiled coil protein 110kDa
CDK12 cyclin-dependent kinase 12
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK2 checkpoint kinase 2
COMT catechol-O-methyltransferase
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTNS cystinosin, lysosomal cystine transporter
CYHR1 cysteine/histidine-rich 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DEAF1 DEAF1 transcription factor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DOCK5 dedicator of cytokinesis 5
FAM50B family with sequence similarity 50, member B
FAM69A family with sequence similarity 69, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FDX1 ferredoxin 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FNDC3A fibronectin type III domain containing 3A
FXR2 fragile X mental retardation, autosomal homolog 2
FYB FYN binding protein
GALK2 galactokinase 2
GAS8 growth arrest-specific 8
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
HOOK1 hook microtubule-tethering protein 1
IFI6 interferon, alpha-inducible protein 6
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1R2 interleukin 1 receptor, type II
ING1 inhibitor of growth family, member 1
INO80B INO80 complex subunit B
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4C lysine (K)-specific demethylase 4C
KIF1A kinesin family member 1A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT2 linker for activation of T cells family, member 2
LMF2 lipase maturation factor 2
LRRC61 leucine rich repeat containing 61
MAPT microtubule-associated protein tau
MGC12488
MTERF4 mitochondrial transcription termination factor 4
MTF2 metal response element binding transcription factor 2
MYH15 myosin, heavy chain 15
NEK1 NIMA-related kinase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODF2 outer dense fiber of sperm tails 2
OSMR oncostatin M receptor
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARP3 poly (ADP-ribose) polymerase family, member 3
PC pyruvate carboxylase
PELO pelota homolog (Drosophila)
PEX6 peroxisomal biogenesis factor 6
PITX2 paired-like homeodomain 2
PLBD1 phospholipase B domain containing 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRSS22 protease, serine, 22
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD51D RAD51 paralog D
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS3A ribosomal protein S3A
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCARB2 scavenger receptor class B, member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SGPL1 sphingosine-1-phosphate lyase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A18 solute carrier family 22, member 18
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC39A9 solute carrier family 39, member 9
SMC1A structural maintenance of chromosomes 1A
SPAST spastin
SPRYD7 SPRY domain containing 7
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
SUGP1 SURP and G patch domain containing 1
SYP synaptophysin
TAGLN3 transgelin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TMCC1 transmembrane and coiled-coil domain family 1
TOX4 TOX high mobility group box family member 4
TREX1 three prime repair exonuclease 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR62 WD repeat domain 62
ZNF230 zinc finger protein 230
ZNF451 zinc finger protein 451
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ALS2CL ALS2 C-terminal like
ANXA10 annexin A10
BAHD1 bromo adjacent homology domain containing 1
C16ORF59 chromosome 16 open reading frame 59
CAMTA2 calmodulin binding transcription activator 2
CBX7 chromobox homolog 7
CCDC94 coiled-coil domain containing 94
CDIP1 cell death-inducing p53 target 1
CDKL3 cyclin-dependent kinase-like 3
CEP112 centrosomal protein 112kDa
CHST10 carbohydrate sulfotransferase 10
CLCN2 chloride channel, voltage-sensitive 2
CLK1 CDC-like kinase 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORT cortistatin
CTSK cathepsin K
CUL9 cullin 9
CXCL3 chemokine (C-X-C motif) ligand 3
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DGKZ diacylglycerol kinase, zeta
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAL4 dynein, axonemal, light chain 4
ELP4 elongator acetyltransferase complex subunit 4
ERF Ets2 repressor factor
FBRS fibrosin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
HIST1H1T histone cluster 1, H1t
HIST1H2AM histone cluster 1, H2am
HLA-J major histocompatibility complex, class I, J (pseudogene)
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
KDM5C lysine (K)-specific demethylase 5C
KRCC1 lysine-rich coiled-coil 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRK1 leucine-rich repeat kinase 1
LSR lipolysis stimulated lipoprotein receptor
MAPK12 mitogen-activated protein kinase 12
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAST3 microtubule associated serine/threonine kinase 3
MCM9 minichromosome maintenance complex component 9
MXRA8 matrix-remodelling associated 8
MYL5 myosin, light chain 5, regulatory
NARFL nuclear prelamin A recognition factor-like
NDE1 nudE neurodevelopment protein 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NXPH4 neurexophilin 4
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OLFML2A olfactomedin-like 2A
OSR2 odd-skipped related transciption factor 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAQR6 progestin and adipoQ receptor family member VI
PDE8B phosphodiesterase 8B
PKN1 protein kinase N1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR15L proline rich 15-like
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB5B RAB5B, member RAS oncogene family
RIN1 Ras and Rab interactor 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RUFY2 RUN and FYVE domain containing 2
RUSC2 RUN and SH3 domain containing 2
SCARA3 scavenger receptor class A, member 3
SDC3 syndecan 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIX1 SIX homeobox 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SOX12 SRY (sex determining region Y)-box 12
SPAG4 sperm associated antigen 4
STEAP4 STEAP family member 4
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TLN1 talin 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM115 transmembrane protein 115
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TPRA1 transmembrane protein, adipocyte asscociated 1
TRABD TraB domain containing
TRAIP TRAF interacting protein
TTC26 tetratricopeptide repeat domain 26
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBQLN4 ubiquilin 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEZT vezatin, adherens junctions transmembrane protein
WDR19 WD repeat domain 19
XYLT2 xylosyltransferase II
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF107 zinc finger protein 107
ZNF813 zinc finger protein 813