diclofenac-2756 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the diclofenac-2756 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOM apolipoprotein M
ARID5A AT rich interactive domain 5A (MRF1-like)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
CAPN5 calpain 5
CD79B CD79b molecule, immunoglobulin-associated beta
CHI3L2 chitinase 3-like 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
COL5A1 collagen, type V, alpha 1
COPA coatomer protein complex, subunit alpha
CYLD cylindromatosis (turban tumor syndrome)
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
DLC1 DLC1 Rho GTPase activating protein
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAI2 dynein, axonemal, intermediate chain 2
DOCK6 dedicator of cytokinesis 6
DOK4 docking protein 4
DPYSL4 dihydropyrimidinase-like 4
DVL3 dishevelled segment polarity protein 3
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EPX eosinophil peroxidase
ETV7 ets variant 7
EWSR1 EWS RNA-binding protein 1
EXOSC1 exosome component 1
FAM214B family with sequence similarity 214, member B
FER fer (fps/fes related) tyrosine kinase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GFER growth factor, augmenter of liver regeneration
GMPR guanosine monophosphate reductase
GPR22 G protein-coupled receptor 22
HLA-C major histocompatibility complex, class I, C
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXC8 homeobox C8
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFNA17 interferon, alpha 17
IGHA1 immunoglobulin heavy constant alpha 1
IHH indian hedgehog
IQCK IQ motif containing K
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF4 interferon regulatory factor 4
KHSRP KH-type splicing regulatory protein
KIAA0319L KIAA0319-like
KREMEN2 kringle containing transmembrane protein 2
KRT75 keratin 75, type II
LATS1 large tumor suppressor kinase 1
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LRRN2 leucine rich repeat neuronal 2
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MARK2 MAP/microtubule affinity-regulating kinase 2
MORN1 MORN repeat containing 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MT3 metallothionein 3
MTMR7 myotubularin related protein 7
NCOA2 nuclear receptor coactivator 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NME5 NME/NM23 family member 5
NUP188 nucleoporin 188kDa
NUP50 nucleoporin 50kDa
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDE10A phosphodiesterase 10A
PLAU plasminogen activator, urokinase
PPP5C protein phosphatase 5, catalytic subunit
PSD3 pleckstrin and Sec7 domain containing 3
QPCTL glutaminyl-peptide cyclotransferase-like
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RIMS3 regulating synaptic membrane exocytosis 3
RPL35A ribosomal protein L35a
SAG S-antigen; retina and pineal gland (arrestin)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH2B1 SH2B adaptor protein 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SIM2 single-minded family bHLH transcription factor 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC39A9 solute carrier family 39, member 9
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBC1D2 TBC1 domain family, member 2
TBL1Y transducin (beta)-like 1, Y-linked
TBX19 T-box 19
TBXA2R thromboxane A2 receptor
TDRKH tudor and KH domain containing
TEX40 testis expressed 40
THRB thyroid hormone receptor, beta
TK2 thymidine kinase 2, mitochondrial
TP63 tumor protein p63
TRIM29 tripartite motif containing 29
UPK3A uroplakin 3A
VEGFA vascular endothelial growth factor A
XDH xanthine dehydrogenase
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC17 zinc finger, DHHC-type containing 17
ZNF45 zinc finger protein 45

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
AEN apoptosis enhancing nuclease
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
CA11 carbonic anhydrase XI
CCDC132 coiled-coil domain containing 132
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHKB choline kinase beta
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN15 claudin 15
CST6 cystatin E/M
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM1 dynamin 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELMO3 engulfment and cell motility 3
F8 coagulation factor VIII, procoagulant component
FAM188A family with sequence similarity 188, member A
FBXO22 F-box protein 22
FGL1 fibrinogen-like 1
FLJ11710 uncharacterized protein FLJ11710
FOXN2 forkhead box N2
FPGS folylpolyglutamate synthase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GFI1 growth factor independent 1 transcription repressor
GK3P glycerol kinase 3 pseudogene
GPR87 G protein-coupled receptor 87
HIST1H2AL histone cluster 1, H2al
HOXC5 homeobox C5
HPS6 Hermansky-Pudlak syndrome 6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP6 insulin-like growth factor binding protein 6
IL22 interleukin 22
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JRKL JRK-like
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF13B kinesin family member 13B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MEFV Mediterranean fever
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPL52 mitochondrial ribosomal protein L52
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NCALD neurocalcin delta
NOL12 nucleolar protein 12
NPIPB15 nuclear pore complex interacting protein family, member B15
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAIP2B poly(A) binding protein interacting protein 2B
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA2G15 phospholipase A2, group XV
PNPLA6 patatin-like phospholipase domain containing 6
POMT2 protein-O-mannosyltransferase 2
PTPRU protein tyrosine phosphatase, receptor type, U
PXMP4 peroxisomal membrane protein 4, 24kDa
RIN1 Ras and Rab interactor 1
ROM1 retinal outer segment membrane protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35F6 solute carrier family 35, member F6
SLC46A3 solute carrier family 46, member 3
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SPATA2L spermatogenesis associated 2-like
STARD13 StAR-related lipid transfer (START) domain containing 13
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D17 TBC1 domain family, member 17
TESC tescalcin
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TMEM242 transmembrane protein 242
TOM1 target of myb1 (chicken)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPYL2 TSPY-like 2
TTLL1 tubulin tyrosine ligase-like family member 1
TUBG2 tubulin, gamma 2
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
VASH1 vasohibin 1
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XK X-linked Kx blood group
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF282 zinc finger protein 282
ZNF324 zinc finger protein 324
ZNF552 zinc finger protein 552
ZNF639 zinc finger protein 639
ZNF787 zinc finger protein 787
ZNF862 zinc finger protein 862