diclofenac-333 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the diclofenac-333 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOH apolipoprotein H (beta-2-glycoprotein I)
APOOL apolipoprotein O-like
ASTE1 asteroid homolog 1 (Drosophila)
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
C19ORF73 chromosome 19 open reading frame 73
C2ORF54 chromosome 2 open reading frame 54
CBX8 chromobox homolog 8
CCDC7 coiled-coil domain containing 7
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDK18 cyclin-dependent kinase 18
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CIDEC cell death-inducing DFFA-like effector c
CIITA class II, major histocompatibility complex, transactivator
CLTCL1 clathrin, heavy chain-like 1
COMT catechol-O-methyltransferase
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSN2 casein beta
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DAXX death-domain associated protein
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DLG3 discs, large homolog 3 (Drosophila)
DUS2 dihydrouridine synthase 2
EFS embryonal Fyn-associated substrate
ESR2 estrogen receptor 2 (ER beta)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGF9 fibroblast growth factor 9
FGFBP1 fibroblast growth factor binding protein 1
FH fumarate hydratase
GCKR glucokinase (hexokinase 4) regulator
GDAP1 ganglioside induced differentiation associated protein 1
GIMAP5 GTPase, IMAP family member 5
GOLM1 golgi membrane protein 1
GPR35 G protein-coupled receptor 35
GPSM3 G-protein signaling modulator 3
GSK3A glycogen synthase kinase 3 alpha
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HIST1H2AM histone cluster 1, H2am
HIST1H2BD histone cluster 1, H2bd
HIST1H3J histone cluster 1, H3j
HLA-E major histocompatibility complex, class I, E
IFITM1 interferon induced transmembrane protein 1
IL33R interleukin 33 receptor
JAG1 jagged 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL25 kelch-like family member 25
KLHL36 kelch-like family member 36
LINC00339 long intergenic non-protein coding RNA 339
LY86 lymphocyte antigen 86
MED1 mediator complex subunit 1
MOXD1 monooxygenase, DBH-like 1
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
N4BP2L2 NEDD4 binding protein 2-like 2
NUPL2 nucleoporin like 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARVA parvin, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PGRMC2 progesterone receptor membrane component 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PQLC2 PQ loop repeat containing 2
PRAME preferentially expressed antigen in melanoma
PRSS16 protease, serine, 16 (thymus)
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABIF RAB interacting factor
RFX3 regulatory factor X, 3 (influences HLA class II expression)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SETD4 SET domain containing 4
SH2B1 SH2B adaptor protein 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPN sialophorin
SUGP2 SURP and G patch domain containing 2
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYN1 synapsin I
TBX5 T-box 5
TLN2 talin 2
TNN tenascin N
TTC26 tetratricopeptide repeat domain 26
UBE4B ubiquitination factor E4B
VCAM1 vascular cell adhesion molecule 1
ZCCHC6 zinc finger, CCHC domain containing 6
ZFPL1 zinc finger protein-like 1
ZNF277 zinc finger protein 277
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALX1 ALX homeobox 1
ARMC7 armadillo repeat containing 7
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB2 arrestin, beta 2
ATP13A2 ATPase type 13A2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BHMT betaine--homocysteine S-methyltransferase
BTBD2 BTB (POZ) domain containing 2
C2 complement component 2
CA11 carbonic anhydrase XI
CAV3 caveolin 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC94 coiled-coil domain containing 94
CCNK cyclin K
CD151 CD151 molecule (Raph blood group)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHRM4 cholinergic receptor, muscarinic 4
CNTD2 cyclin N-terminal domain containing 2
COPZ2 coatomer protein complex, subunit zeta 2
CRYAB crystallin, alpha B
CTSD cathepsin D
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNASE1L2 deoxyribonuclease I-like 2
ERCC2 excision repair cross-complementation group 2
ERO1L ERO1-like (S. cerevisiae)
EVPL envoplakin
FAM110D family with sequence similarity 110, member D
FGL1 fibrinogen-like 1
FHL3 four and a half LIM domains 3
FLNC filamin C, gamma
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUZ fuzzy planar cell polarity protein
GAST gastrin
GDF3 growth differentiation factor 3
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GMIP GEM interacting protein
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPA33 glycoprotein A33 (transmembrane)
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSN-AS1 GSN antisense RNA 1
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
IGFBP4 insulin-like growth factor binding protein 4
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL19 interleukin 19
IL7R interleukin 7 receptor
LENEP lens epithelial protein
LINC00652 long intergenic non-protein coding RNA 652
LOC100127972 uncharacterized LOC100127972
LOC100286895 cell division cycle 27 homolog pseudogene
MCMBP minichromosome maintenance complex binding protein
MEPE matrix extracellular phosphoglycoprotein
MICALL2 MICAL-like 2
MRPL44 mitochondrial ribosomal protein L44
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NNAT neuronatin
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OLFML2A olfactomedin-like 2A
OVOL1 ovo-like zinc finger 1
PACS1 phosphofurin acidic cluster sorting protein 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PMEPA1 prostate transmembrane protein, androgen induced 1
PQLC3 PQ loop repeat containing 3
PRDM11 PR domain containing 11
PRICKLE3 prickle homolog 3 (Drosophila)
PROP1 PROP paired-like homeobox 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB3D RAB3D, member RAS oncogene family
RHOH ras homolog family member H
RORC RAR-related orphan receptor C
SBNO2 strawberry notch homolog 2 (Drosophila)
SETD6 SET domain containing 6
SLC22A18 solute carrier family 22, member 18
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMYD5 SMYD family member 5
SRPK3 SRSF protein kinase 3
SYNDIG1 synapse differentiation inducing 1
SYT2 synaptotagmin II
TCEA2 transcription elongation factor A (SII), 2
THEG theg spermatid protein
TRAC T cell receptor alpha constant
TSPYL2 TSPY-like 2
UBQLN4 ubiquilin 4
VEGFB vascular endothelial growth factor B
WDR13 WD repeat domain 13
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF580 zinc finger protein 580
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2