diclofenac-5861 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the diclofenac-5861 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCK2 aarF domain containing kinase 2
AFF4 AF4/FMR2 family, member 4
AQP7 aquaporin 7
AQP9 aquaporin 9
ARHGAP26 Rho GTPase activating protein 26
ARHGAP35 Rho GTPase activating protein 35
ASMTL acetylserotonin O-methyltransferase-like
BCAP29 B-cell receptor-associated protein 29
BGN biglycan
CCL2 chemokine (C-C motif) ligand 2
CD79B CD79b molecule, immunoglobulin-associated beta
CDHR2 cadherin-related family member 2
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CELF2 CUGBP, Elav-like family member 2
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHRM5 cholinergic receptor, muscarinic 5
COL14A1 collagen, type XIV, alpha 1
CORO2B coronin, actin binding protein, 2B
CRLF1 cytokine receptor-like factor 1
CRTC1 CREB regulated transcription coactivator 1
CTNS cystinosin, lysosomal cystine transporter
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DCN decorin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EIF3F eukaryotic translation initiation factor 3, subunit F
EML3 echinoderm microtubule associated protein like 3
FAM189A1 family with sequence similarity 189, member A1
FOXO4 forkhead box O4
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GFRA2 GDNF family receptor alpha 2
GPR15 G protein-coupled receptor 15
HIST1H4A histone cluster 1, H4a
IL11 interleukin 11
ING1 inhibitor of growth family, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KRT34 keratin 34, type I
LAMB4 laminin, beta 4
LIPG lipase, endothelial
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
LPAR4 lysophosphatidic acid receptor 4
LRP4 low density lipoprotein receptor-related protein 4
LRRK1 leucine-rich repeat kinase 1
MAP7 microtubule-associated protein 7
MAPK10 mitogen-activated protein kinase 10
MDFI MyoD family inhibitor
MGAM maltase-glucoamylase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSL3 male-specific lethal 3 homolog (Drosophila)
MTA2 metastasis associated 1 family, member 2
MUC4 mucin 4, cell surface associated
NNAT neuronatin
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
ODAM odontogenic, ameloblast asssociated
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POU5F1B POU class 5 homeobox 1B
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRMT2IP PRMT2 interacting protein
PRUNE2 prune homolog 2 (Drosophila)
PSG5 pregnancy specific beta-1-glycoprotein 5
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYY peptide YY
RARG retinoic acid receptor, gamma
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SARM1 sterile alpha and TIR motif containing 1
SCARB2 scavenger receptor class B, member 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SIX3 SIX homeobox 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLN sarcolipin
SORBS1 sorbin and SH3 domain containing 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBCD tubulin folding cofactor D
THRB thyroid hormone receptor, beta
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TOP3A topoisomerase (DNA) III alpha
TSPAN8 tetraspanin 8
TYR tyrosinase
UBOX5 U-box domain containing 5
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WIPF1 WAS/WASL interacting protein family, member 1
WSB1 WD repeat and SOCS box containing 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ACSL4 acyl-CoA synthetase long-chain family member 4
ACYP1 acylphosphatase 1, erythrocyte (common) type
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATG9A autophagy related 9A
ATP13A2 ATPase type 13A2
BAG4 BCL2-associated athanogene 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
C1ORF115 chromosome 1 open reading frame 115
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CDC37L1 cell division cycle 37-like 1
CDK9 cyclin-dependent kinase 9
CHPF chondroitin polymerizing factor
CLDN15 claudin 15
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
DCAF17 DDB1 and CUL4 associated factor 17
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EFNA3 ephrin-A3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC5 exocyst complex component 5
FADS2 fatty acid desaturase 2
FAIM Fas apoptotic inhibitory molecule
FEM1C fem-1 homolog c (C. elegans)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
HSPB8 heat shock 22kDa protein 8
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IMPACT impact RWD domain protein
IQCE IQ motif containing E
IREB2 iron-responsive element binding protein 2
JUNB jun B proto-oncogene
KLK6 kallikrein-related peptidase 6
LRP5L low density lipoprotein receptor-related protein 5-like
LUC7L LUC7-like (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGEA6 melanoma antigen family A6
MAP9 microtubule-associated protein 9
MAPK3 mitogen-activated protein kinase 3
MCRS1 microspherule protein 1
MICU1 mitochondrial calcium uptake 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MORC3 MORC family CW-type zinc finger 3
MRPS34 mitochondrial ribosomal protein S34
MVP major vault protein
MYL12B myosin, light chain 12B, regulatory
MYLK myosin light chain kinase
NADSYN1 NAD synthetase 1
NRSN2 neurensin 2
NUBP2 nucleotide binding protein 2
PDZD2 PDZ domain containing 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLA2G15 phospholipase A2, group XV
PLAC8 placenta-specific 8
PORCN porcupine homolog (Drosophila)
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRMT7 protein arginine methyltransferase 7
PTDSS2 phosphatidylserine synthase 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGCC regulator of cell cycle
RNF121 ring finger protein 121
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A4 S100 calcium binding protein A4
SCN1B sodium channel, voltage gated, type I beta subunit
SCYL2 SCY1-like 2 (S. cerevisiae)
SERTAD3 SERTA domain containing 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC12A8 solute carrier family 12, member 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC38A6 solute carrier family 38, member 6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SNX16 sorting nexin 16
SPAG1 sperm associated antigen 1
SPATA2L spermatogenesis associated 2-like
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAGLN3 transgelin 3
TCTN1 tectonic family member 1
TENM4 teneurin transmembrane protein 4
TM7SF3 transmembrane 7 superfamily member 3
TMEM8A transmembrane protein 8A
TUBA3D tubulin, alpha 3d
TUBGCP5 tubulin, gamma complex associated protein 5
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
USP6 ubiquitin specific peptidase 6
ZNF350 zinc finger protein 350
ZNF629 zinc finger protein 629