dicycloverine-1483 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dicycloverine-1483 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACPP acid phosphatase, prostate
ALPK1 alpha-kinase 1
ANKRD26 ankyrin repeat domain 26
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOM apolipoprotein M
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
ATRX alpha thalassemia/mental retardation syndrome X-linked
BCAS1 breast carcinoma amplified sequence 1
BHLHE40 basic helix-loop-helix family, member e40
BMP8B bone morphogenetic protein 8b
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRM3 cholinergic receptor, muscarinic 3
CLCF1 cardiotrophin-like cytokine factor 1
COL5A1 collagen, type V, alpha 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR4 chemokine (C-X-C motif) receptor 4
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLX2 distal-less homeobox 2
DMPK dystrophia myotonica-protein kinase
DSCAM Down syndrome cell adhesion molecule
DUSP1 dual specificity phosphatase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
FAM76A family with sequence similarity 76, member A
FGF18 fibroblast growth factor 18
FGF2 fibroblast growth factor 2 (basic)
FLJ42627 uncharacterized LOC645644
FOS FBJ murine osteosarcoma viral oncogene homolog
HAP1 huntingtin-associated protein 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-E major histocompatibility complex, class I, E
HOXC8 homeobox C8
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL5RA interleukin 5 receptor, alpha
INHBE inhibin, beta E
IQCE IQ motif containing E
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
LMAN1 lectin, mannose-binding, 1
LOX lysyl oxidase
LRRC37A3 leucine rich repeat containing 37, member A3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBTD1 mbt domain containing 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MID1 midline 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MR1 major histocompatibility complex, class I-related
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OASL 2'-5'-oligoadenylate synthetase-like
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRDM2 PR domain containing 2, with ZNF domain
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RXRB retinoid X receptor, beta
SCAPER S-phase cyclin A-associated protein in the ER
SCN10A sodium channel, voltage gated, type X alpha subunit
SH3BP2 SH3-domain binding protein 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
TGFB2 transforming growth factor, beta 2
TMEM259 transmembrane protein 259
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSGA10 testis specific, 10
VEGFA vascular endothelial growth factor A
WDR19 WD repeat domain 19
ZFP36 ZFP36 ring finger protein
ZNF324 zinc finger protein 324
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALG12 ALG12, alpha-1,6-mannosyltransferase
APOD apolipoprotein D
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
BMP4 bone morphogenetic protein 4
C19ORF73 chromosome 19 open reading frame 73
CAPG capping protein (actin filament), gelsolin-like
CAPRIN2 caprin family member 2
CHST10 carbohydrate sulfotransferase 10
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CIC capicua transcriptional repressor
CLCN5 chloride channel, voltage-sensitive 5
CPTP ceramide-1-phosphate transfer protein
CRIPT cysteine-rich PDZ-binding protein
CST6 cystatin E/M
CXORF56 chromosome X open reading frame 56
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DOCK1 dedicator of cytokinesis 1
EAF2 ELL associated factor 2
EFNA3 ephrin-A3
ELP3 elongator acetyltransferase complex subunit 3
ENO2 enolase 2 (gamma, neuronal)
ETAA1 Ewing tumor-associated antigen 1
FAIM Fas apoptotic inhibitory molecule
FCHO1 FCH domain only 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR19 G protein-coupled receptor 19
GRTP1 growth hormone regulated TBC protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GYS1 glycogen synthase 1 (muscle)
HDAC4 histone deacetylase 4
HIST1H2AJ histone cluster 1, H2aj
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1L heat shock 70kDa protein 1-like
IL4R interleukin 4 receptor
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KAT2A K(lysine) acetyltransferase 2A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0556 KIAA0556
KIF23 kinesin family member 23
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
LIG4 ligase IV, DNA, ATP-dependent
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP2 low density lipoprotein receptor-related protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAN2B2 mannosidase, alpha, class 2B, member 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEFV Mediterranean fever
METTL16 methyltransferase like 16
METTL8 methyltransferase like 8
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NPIPB15 nuclear pore complex interacting protein family, member B15
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OLFML3 olfactomedin-like 3
OSMR oncostatin M receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARD6A par-6 family cell polarity regulator alpha
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA2G10 phospholipase A2, group X
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PRSS16 protease, serine, 16 (thymus)
QSER1 glutamine and serine rich 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RNF43 ring finger protein 43
RPL23AP7 ribosomal protein L23a pseudogene 7
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIX1 SIX homeobox 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNHG3 small nucleolar RNA host gene 3
SOX12 SRY (sex determining region Y)-box 12
SOX3 SRY (sex determining region Y)-box 3
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRYD7 SPRY domain containing 7
STARD3 StAR-related lipid transfer (START) domain containing 3
TAGLN transgelin
TLN1 talin 1
TMEM104 transmembrane protein 104
TMEM57 transmembrane protein 57
TRAIP TRAF interacting protein
TRAPPC13 trafficking protein particle complex 13
USP19 ubiquitin specific peptidase 19
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZFHX3 zinc finger homeobox 3
ZMYM3 zinc finger, MYM-type 3
ZNF350 zinc finger protein 350
ZNF423 zinc finger protein 423
ZNF442 zinc finger protein 442
ZNF552 zinc finger protein 552
ZSCAN31 zinc finger and SCAN domain containing 31
ZXDC ZXD family zinc finger C