dicycloverine-1983 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dicycloverine-1983 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADAM8 ADAM metallopeptidase domain 8
ADARB1 adenosine deaminase, RNA-specific, B1
ADRBK2 adrenergic, beta, receptor kinase 2
AKAP13 A kinase (PRKA) anchor protein 13
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ASPH aspartate beta-hydroxylase
ATXN2 ataxin 2
BAHCC1 BAH domain and coiled-coil containing 1
BCL7A B-cell CLL/lymphoma 7A
BCL7C B-cell CLL/lymphoma 7C
BMP15 bone morphogenetic protein 15
BTN3A2 butyrophilin, subfamily 3, member A2
C16ORF58 chromosome 16 open reading frame 58
CBX6 chromobox homolog 6
CD37 CD37 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPT centromere protein T
CLCN6 chloride channel, voltage-sensitive 6
CLCN7 chloride channel, voltage-sensitive 7
COG7 component of oligomeric golgi complex 7
CPNE1 copine I
CTIF CBP80/20-dependent translation initiation factor
DIDO1 death inducer-obliterator 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
ELK1 ELK1, member of ETS oncogene family
EMC1 ER membrane protein complex subunit 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHB2 EPH receptor B2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLNB filamin B, beta
FMOD fibromodulin
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
HEMK1 HemK methyltransferase family member 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGSF6 immunoglobulin superfamily, member 6
INTS1 integrator complex subunit 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA1045 KIAA1045
LBP lipopolysaccharide binding protein
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAGEB2 melanoma antigen family B2
MAP2K5 mitogen-activated protein kinase kinase 5
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MTMR2 myotubularin related protein 2
MTMR3 myotubularin related protein 3
MX1 MX dynamin-like GTPase 1
MYL10 myosin, light chain 10, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NCKIPSD NCK interacting protein with SH3 domain
ONECUT2 one cut homeobox 2
OVGP1 oviductal glycoprotein 1, 120kDa
PAM peptidylglycine alpha-amidating monooxygenase
PCSK7 proprotein convertase subtilisin/kexin type 7
PDLIM1 PDZ and LIM domain 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POR P450 (cytochrome) oxidoreductase
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
QTRT1 queuine tRNA-ribosyltransferase 1
RECQL5 RecQ protein-like 5
RPL31 ribosomal protein L31
SEC31B SEC31 homolog B (S. cerevisiae)
SPDEF SAM pointed domain containing ETS transcription factor
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
STAR steroidogenic acute regulatory protein
STK19 serine/threonine kinase 19
STX6 syntaxin 6
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TERF2 telomeric repeat binding factor 2
THEM6 thioesterase superfamily member 6
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TMUB2 transmembrane and ubiquitin-like domain containing 2
TOR4A torsin family 4, member A
TRABD TraB domain containing
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSC2 tuberous sclerosis 2
VAC14 Vac14 homolog (S. cerevisiae)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF335 zinc finger protein 335
ZNF408 zinc finger protein 408
ZNF574 zinc finger protein 574
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACYP2 acylphosphatase 2, muscle type
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHR aryl hydrocarbon receptor
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
B3GNT1
BAG2 BCL2-associated athanogene 2
BCL10 B-cell CLL/lymphoma 10
C12ORF49 chromosome 12 open reading frame 49
C1ORF109 chromosome 1 open reading frame 109
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC91 coiled-coil domain containing 91
CGRRF1 cell growth regulator with ring finger domain 1
CLEC16A C-type lectin domain family 16, member A
CRY1 cryptochrome circadian clock 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSNK1G3 casein kinase 1, gamma 3
CTNNBL1 catenin, beta like 1
DCK deoxycytidine kinase
DCLRE1B DNA cross-link repair 1B
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DENND4A DENN/MADD domain containing 4A
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DIXDC1 DIX domain containing 1
DMXL1 Dmx-like 1
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
EIF1B eukaryotic translation initiation factor 1B
ERBB2IP erbb2 interacting protein
ERF Ets2 repressor factor
FAM206A family with sequence similarity 206, member A
FBXO5 F-box protein 5
FBXW4 F-box and WD repeat domain containing 4
FUBP3 far upstream element (FUSE) binding protein 3
FYCO1 FYVE and coiled-coil domain containing 1
GDAP2 ganglioside induced differentiation associated protein 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1E histone cluster 1, H1e
IMPACT impact RWD domain protein
INO80D INO80 complex subunit D
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDM5C lysine (K)-specific demethylase 5C
LYZ lysozyme
MAGOHB mago-nashi homolog B (Drosophila)
MIS18BP1 MIS18 binding protein 1
MPHOSPH8 M-phase phosphoprotein 8
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYL12B myosin, light chain 12B, regulatory
MYO19 myosin XIX
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NMD3 NMD3 ribosome export adaptor
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPL1 nucleoporin like 1
OCEL1 occludin/ELL domain containing 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PARG poly (ADP-ribose) glycohydrolase
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PRDM13 PR domain containing 13
RAP1A RAP1A, member of RAS oncogene family
RBBP5 retinoblastoma binding protein 5
RCL1 RNA terminal phosphate cyclase-like 1
RNF144A ring finger protein 144A
RPL26 ribosomal protein L26
RPS25 ribosomal protein S25
SATB1 SATB homeobox 1
SDC4 syndecan 4
SDHAF3 succinate dehydrogenase complex assembly factor 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEPW1 selenoprotein W, 1
SETD4 SET domain containing 4
SETMAR SET domain and mariner transposase fusion gene
SFT2D2 SFT2 domain containing 2
SKI SKI proto-oncogene
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLMO2 slowmo homolog 2 (Drosophila)
SPC25 SPC25, NDC80 kinetochore complex component
SRP9 signal recognition particle 9kDa
STAG1 stromal antigen 1
SUCO SUN domain containing ossification factor
TAOK1 TAO kinase 1
TCTN2 tectonic family member 2
TM7SF2 transmembrane 7 superfamily member 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM110 transmembrane protein 110
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAC T cell receptor alpha constant
TRAIP TRAF interacting protein
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2O ubiquitin-conjugating enzyme E2O
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USP32 ubiquitin specific peptidase 32
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
WRN Werner syndrome, RecQ helicase-like
ZC3H12A zinc finger CCCH-type containing 12A
ZFP30 ZFP30 zinc finger protein
ZNF211 zinc finger protein 211
ZNF587 zinc finger protein 587