dicycloverine-4405 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the dicycloverine-4405 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACOX2 acyl-CoA oxidase 2, branched chain
ASIC2 acid sensing (proton gated) ion channel 2
ATF3 activating transcription factor 3
BCO1 beta-carotene oxygenase 1
BHLHE40 basic helix-loop-helix family, member e40
C3ORF18 chromosome 3 open reading frame 18
CCDC68 coiled-coil domain containing 68
CCRL2 chemokine (C-C motif) receptor-like 2
CD48 CD48 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEP135 centrosomal protein 135kDa
CEP295 centrosomal protein 295kDa
CLDN1 claudin 1
COL3A1 collagen, type III, alpha 1
CORO2B coronin, actin binding protein, 2B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGR1 early growth response 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GCKR glucokinase (hexokinase 4) regulator
GEM GTP binding protein overexpressed in skeletal muscle
GFI1 growth factor independent 1 transcription repressor
GTPBP1 GTP binding protein 1
HIPK3 homeodomain interacting protein kinase 3
HIST1H3B histone cluster 1, H3b
HOXB5 homeobox B5
HRH1 histamine receptor H1
ICAM1 intercellular adhesion molecule 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBE inhibin, beta E
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAM3 junctional adhesion molecule 3
JUN jun proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KIAA1107 KIAA1107
KLF2 Kruppel-like factor 2
KRT37 keratin 37, type I
LEFTY2 left-right determination factor 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA5 melanoma antigen family A5
MAU2 MAU2 sister chromatid cohesion factor
MBNL2 muscleblind-like splicing regulator 2
MDM4 MDM4, p53 regulator
MED25 mediator complex subunit 25
MET MET proto-oncogene, receptor tyrosine kinase
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MUC8 mucin 8
MYCNOS MYCN opposite strand
N4BP2L1 NEDD4 binding protein 2-like 1
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP54 nucleoporin 54kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PDLIM3 PDZ and LIM domain 3
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTCH1 patched 1
RAB6A RAB6A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
RUNX1 runt-related transcription factor 1
SAYSD1 SAYSVFN motif domain containing 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3BP2 SH3-domain binding protein 2
SKAP1 src kinase associated phosphoprotein 1
SKIL SKI-like proto-oncogene
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPPL2B signal peptide peptidase like 2B
SRPK2 SRSF protein kinase 2
SYNPO synaptopodin
SYP synaptophysin
TLR2 toll-like receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UMPS uridine monophosphate synthetase
YTHDC2 YTH domain containing 2
ZBTB6 zinc finger and BTB domain containing 6
ZFP64 ZFP64 zinc finger protein
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AARSD1 alanyl-tRNA synthetase domain containing 1
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACBD4 acyl-CoA binding domain containing 4
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
APLP1 amyloid beta (A4) precursor-like protein 1
ARPIN actin-related protein 2/3 complex inhibitor
AUTS2 autism susceptibility candidate 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BTF3P11 basic transcription factor 3 pseudogene 11
C10ORF95 chromosome 10 open reading frame 95
C14ORF79 chromosome 14 open reading frame 79
CAMTA2 calmodulin binding transcription activator 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX2 chromobox homolog 2
CCDC64 coiled-coil domain containing 64
CD3D CD3d molecule, delta (CD3-TCR complex)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHKB choline kinase beta
CHRM3 cholinergic receptor, muscarinic 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTNNBIP1 catenin, beta interacting protein 1
CTRL chymotrypsin-like
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGAT1 diacylglycerol O-acyltransferase 1
DGKQ diacylglycerol kinase, theta 110kDa
DLK2 delta-like 2 homolog (Drosophila)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DRD1 dopamine receptor D1
DUSP13 dual specificity phosphatase 13
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGFL7 EGF-like-domain, multiple 7
ELP6 elongator acetyltransferase complex subunit 6
EMID1 EMI domain containing 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL6 F-box and leucine-rich repeat protein 6
FLJ21369 uncharacterized protein FLJ21369
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA9 gap junction protein, alpha 9, 59kDa
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPC3 glypican 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXB2 homeobox B2
HOXC5 homeobox C5
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL2 interleukin 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF13B kinesin family member 13B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL26 kelch-like family member 26
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LIME1 Lck interacting transmembrane adaptor 1
LRRC20 leucine rich repeat containing 20
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MEGF6 multiple EGF-like-domains 6
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MX2 MX dynamin-like GTPase 2
NEUROD1 neuronal differentiation 1
NKX3-2 NK3 homeobox 2
PAIP2B poly(A) binding protein interacting protein 2B
PARD6A par-6 family cell polarity regulator alpha
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PEX26 peroxisomal biogenesis factor 26
PGP phosphoglycolate phosphatase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POU4F2 POU class 4 homeobox 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTCD1 pentatricopeptide repeat domain 1
RAB3A RAB3A, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
RNF122 ring finger protein 122
RNF43 ring finger protein 43
RORC RAR-related orphan receptor C
SEC14L5 SEC14-like 5 (S. cerevisiae)
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPATA2L spermatogenesis associated 2-like
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARP TCR gamma alternate reading frame protein
TBX19 T-box 19
TFF2 trefoil factor 2
TRAIP TRAF interacting protein
TRIM21 tripartite motif containing 21
TRPC5 transient receptor potential cation channel, subfamily C, member 5
VAX2 ventral anterior homeobox 2
ZBTB22 zinc finger and BTB domain containing 22
ZC3H3 zinc finger CCCH-type containing 3
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF446 zinc finger protein 446