dienestrol-5727 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the dienestrol-5727 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSS3 acyl-CoA synthetase short-chain family member 3
AFF4 AF4/FMR2 family, member 4
AGFG1 ArfGAP with FG repeats 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BATF3 basic leucine zipper transcription factor, ATF-like 3
BGN biglycan
BRSK2 BR serine/threonine kinase 2
BTF3P12 basic transcription factor 3 pseudogene 12
C19ORF73 chromosome 19 open reading frame 73
C2ORF54 chromosome 2 open reading frame 54
C8ORF44 chromosome 8 open reading frame 44
CCDC70 coiled-coil domain containing 70
CD52 CD52 molecule
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLEC4A C-type lectin domain family 4, member A
COL8A2 collagen, type VIII, alpha 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCT dopachrome tautomerase
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DIAPH3 diaphanous-related formin 3
DMBT1 deleted in malignant brain tumors 1
DOK4 docking protein 4
DSC2 desmocollin 2
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
FGF1 fibroblast growth factor 1 (acidic)
FNDC3A fibronectin type III domain containing 3A
GATA3 GATA binding protein 3
GK glycerol kinase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR21 G protein-coupled receptor 21
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSK3A glycogen synthase kinase 3 alpha
GSTA3 glutathione S-transferase alpha 3
HIST1H4F histone cluster 1, H4f
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL33R interleukin 33 receptor
INADL InaD-like (Drosophila)
IRF4 interferon regulatory factor 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD14 potassium channel tetramerization domain containing 14
KLHL25 kelch-like family member 25
KRT17 keratin 17, type I
KRT2 keratin 2, type II
MAPK14 mitogen-activated protein kinase 14
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDM4 MDM4, p53 regulator
MEF2C myocyte enhancer factor 2C
MFSD6 major facilitator superfamily domain containing 6
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MN1 meningioma (disrupted in balanced translocation) 1
MVB12B multivesicular body subunit 12B
MYOM2 myomesin 2
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NIN ninein (GSK3B interacting protein)
NOTCH4 notch 4
NUP88 nucleoporin 88kDa
OPCML opioid binding protein/cell adhesion molecule-like
PADI2 peptidyl arginine deiminase, type II
PDE11A phosphodiesterase 11A
PECAM1 platelet/endothelial cell adhesion molecule 1
PITX1 paired-like homeodomain 1
PKLR pyruvate kinase, liver and RBC
PLA2G5 phospholipase A2, group V
POU4F1 POU class 4 homeobox 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRR protein tyrosine phosphatase, receptor type, R
RAB27B RAB27B, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RNF43 ring finger protein 43
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SH3BP2 SH3-domain binding protein 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOCS3 suppressor of cytokine signaling 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SRCAP Snf2-related CREBBP activator protein
SV2A synaptic vesicle glycoprotein 2A
TACR1 tachykinin receptor 1
TAGLN3 transgelin 3
TCF4 transcription factor 4
TGFB2 transforming growth factor, beta 2
TMEM212 transmembrane protein 212
TRIM10 tripartite motif containing 10
TUBA3C tubulin, alpha 3c
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP27X ubiquitin specific peptidase 27, X-linked
VAMP5 vesicle-associated membrane protein 5
VAV3 vav 3 guanine nucleotide exchange factor
YIPF2 Yip1 domain family, member 2
ZBTB14 zinc finger and BTB domain containing 14
ZNF639 zinc finger protein 639
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ASIC3 acid sensing (proton gated) ion channel 3
BAHCC1 BAH domain and coiled-coil containing 1
BEX1 brain expressed, X-linked 1
C4ORF19 chromosome 4 open reading frame 19
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN15 calpain 15
CCNJL cyclin J-like
CCP110 centriolar coiled coil protein 110kDa
CDT1 chromatin licensing and DNA replication factor 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CIDEC cell death-inducing DFFA-like effector c
CLIP2 CAP-GLY domain containing linker protein 2
CNGB3 cyclic nucleotide gated channel beta 3
CRY2 cryptochrome circadian clock 2
CRYBA2 crystallin, beta A2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DBF4B DBF4 zinc finger B
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DTX2 deltex 2, E3 ubiquitin ligase
EPHX2 epoxide hydrolase 2, cytoplasmic
EVPL envoplakin
FAM50B family with sequence similarity 50, member B
FRS3 fibroblast growth factor receptor substrate 3
GAL3ST4 galactose-3-O-sulfotransferase 4
GAREM GRB2 associated, regulator of MAPK1
GRAMD1C GRAM domain containing 1C
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL17RB interleukin 17 receptor B
IL4R interleukin 4 receptor
IPO8 importin 8
IRF9 interferon regulatory factor 9
ITPKC inositol-trisphosphate 3-kinase C
KLF3 Kruppel-like factor 3 (basic)
KRT31 keratin 31, type I
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
LPAR3 lysophosphatidic acid receptor 3
LRRC61 leucine rich repeat containing 61
MAGEB2 melanoma antigen family B2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MTA2 metastasis associated 1 family, member 2
MX1 MX dynamin-like GTPase 1
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NINL ninein-like
NOD1 nucleotide-binding oligomerization domain containing 1
NRTN neurturin
NTSR1 neurotensin receptor 1 (high affinity)
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
PC pyruvate carboxylase
PCDHGB5 protocadherin gamma subfamily B, 5
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLD2 phospholipase D2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR15L proline rich 15-like
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RAI2 retinoic acid induced 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUSC2 RUN and SH3 domain containing 2
SCARA3 scavenger receptor class A, member 3
SCN9A sodium channel, voltage gated, type IX alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SKA1 spindle and kinetochore associated complex subunit 1
SLC25A40 solute carrier family 25, member 40
SLC46A3 solute carrier family 46, member 3
SNTA1 syntrophin, alpha 1
SNX15 sorting nexin 15
SOD3 superoxide dismutase 3, extracellular
SRD5A3 steroid 5 alpha-reductase 3
SULT4A1 sulfotransferase family 4A, member 1
TCEAL2 transcription elongation factor A (SII)-like 2
TNNI3 troponin I type 3 (cardiac)
TOM1 target of myb1 (chicken)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UNC119 unc-119 homolog (C. elegans)
WDR76 WD repeat domain 76
ZC3H12A zinc finger CCCH-type containing 12A
ZNF137P zinc finger protein 137, pseudogene
ZNF408 zinc finger protein 408
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816