diethylcarbamazine-5066 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the diethylcarbamazine-5066 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACE angiotensin I converting enzyme
ACVR1B activin A receptor, type IB
ADAM23 ADAM metallopeptidase domain 23
ADAP1 ArfGAP with dual PH domains 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRV1 adhesion G protein-coupled receptor V1
AIM2 absent in melanoma 2
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALOXE3 arachidonate lipoxygenase 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANP32A-IT1 ANP32A intronic transcript 1
ATF6B activating transcription factor 6 beta
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
AVP arginine vasopressin
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BPY2 basic charge, Y-linked, 2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAPN6 calpain 6
CCL19 chemokine (C-C motif) ligand 19
CD1B CD1b molecule
CD209 CD209 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CIC capicua transcriptional repressor
CLEC11A C-type lectin domain family 11, member A
CSHL1 chorionic somatomammotropin hormone-like 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYTH3 cytohesin 3
EFS embryonal Fyn-associated substrate
EMX1 empty spiracles homeobox 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FLJ11292
FLT3LG fms-related tyrosine kinase 3 ligand
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAL galanin/GMAP prepropeptide
GSK3A glycogen synthase kinase 3 alpha
HIST1H2BM histone cluster 1, H2bm
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HPSE2 heparanase 2 (inactive)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM2 intercellular adhesion molecule 2
IL12B interleukin 12B
IL17RB interleukin 17 receptor B
IL33 interleukin 33
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KYNU kynureninase
LINC00115 long intergenic non-protein coding RNA 115
LUZP4 leucine zipper protein 4
METTL7A methyltransferase like 7A
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NACAD NAC alpha domain containing
NEBL nebulette
NEUROG1 neurogenin 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOVA2 neuro-oncological ventral antigen 2
NPR1 natriuretic peptide receptor 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PAX2 paired box 2
PCDHB13 protocadherin beta 13
PCDHB17P protocadherin beta 17 pseudogene
PCDHB3 protocadherin beta 3
PDE4DIP phosphodiesterase 4D interacting protein
POU4F1 POU class 4 homeobox 1
PRDX2 peroxiredoxin 2
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RAD52 RAD52 homolog (S. cerevisiae)
RIMS2 regulating synaptic membrane exocytosis 2
RIT2 Ras-like without CAAX 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SAA3P serum amyloid A3 pseudogene
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIRAL2 SIR2 antiphage like 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLCO1C1 solute carrier organic anion transporter family, member 1C1
STMN4 stathmin-like 4
TAAR5 trace amine associated receptor 5
THAP9 THAP domain containing 9
TMSB4Y thymosin beta 4, Y-linked
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAC T cell receptor alpha constant
TSC22D3 TSC22 domain family, member 3
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UTF1 undifferentiated embryonic cell transcription factor 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBED4 zinc finger, BED-type containing 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
AFAP1 actin filament associated protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD36B ankyrin repeat domain 36B
ARHGAP11A Rho GTPase activating protein 11A
BAG4 BCL2-associated athanogene 4
BEX1 brain expressed, X-linked 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C3ORF52 chromosome 3 open reading frame 52
CA5B carbonic anhydrase VB, mitochondrial
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CEP112 centrosomal protein 112kDa
CHM choroideremia (Rab escort protein 1)
CIR1 corepressor interacting with RBPJ, 1
CLDN1 claudin 1
CLDN11 claudin 11
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CPA4 carboxypeptidase A4
CPNE7 copine VII
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSK cathepsin K
EDIL3 EGF-like repeats and discoidin I-like domains 3
EHD3 EH-domain containing 3
ERCC5 excision repair cross-complementation group 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAT4 FAT atypical cadherin 4
FGD1 FYVE, RhoGEF and PH domain containing 1
FZD3 frizzled class receptor 3
GID4 GID complex subunit 4
GLCE glucuronic acid epimerase
GMEB1 glucocorticoid modulatory element binding protein 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPATCH1 G patch domain containing 1
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AG histone cluster 1, H2ag
HIST1H2AM histone cluster 1, H2am
HIST1H4C histone cluster 1, H4c
HIST1H4E histone cluster 1, H4e
HOMER2 homer scaffolding protein 2
HOXA4 homeobox A4
HOXB9 homeobox B9
HOXC13 homeobox C13
IFI6 interferon, alpha-inducible protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
LMO7 LIM domain 7
MAGEH1 melanoma antigen family H1
MAST3 microtubule associated serine/threonine kinase 3
MLYCD malonyl-CoA decarboxylase
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MTMR11 myotubularin related protein 11
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSTM1 osteopetrosis associated transmembrane protein 1
PACS1 phosphofurin acidic cluster sorting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARD6A par-6 family cell polarity regulator alpha
PLSCR4 phospholipid scramblase 4
PRR4 proline rich 4 (lacrimal)
R3HDM2 R3H domain containing 2
RABL6 RAB, member RAS oncogene family-like 6
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RNF31 ring finger protein 31
RPL23AP32 ribosomal protein L23a pseudogene 32
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SESN1 sestrin 1
SGMS1 sphingomyelin synthase 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD3 superoxide dismutase 3, extracellular
SPATA2L spermatogenesis associated 2-like
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM53 transmembrane protein 53
TMEM8B transmembrane protein 8B
TSPAN12 tetraspanin 12
TUBA3C tubulin, alpha 3c
UGT8 UDP glycosyltransferase 8
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VWA1 von Willebrand factor A domain containing 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB48 zinc finger and BTB domain containing 48
ZFP30 ZFP30 zinc finger protein
ZNF230 zinc finger protein 230
ZNF273 zinc finger protein 273
ZNF304 zinc finger protein 304
ZNF33B zinc finger protein 33B
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene
ZNF767P zinc finger family member 767, pseudogene
ZXDC ZXD family zinc finger C