diethylcarbamazine-5485 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the diethylcarbamazine-5485 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRA2 adhesion G protein-coupled receptor A2
ADGRL1 adhesion G protein-coupled receptor L1
AGMAT agmatine ureohydrolase (agmatinase)
ALPPL2 alkaline phosphatase, placental-like 2
ANGEL2 angel homolog 2 (Drosophila)
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARHGAP44 Rho GTPase activating protein 44
ARL4D ADP-ribosylation factor-like 4D
ASIC1 acid sensing (proton gated) ion channel 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BMP1 bone morphogenetic protein 1
C7ORF69 chromosome 7 open reading frame 69
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCP110 centriolar coiled coil protein 110kDa
CD300C CD300c molecule
CDC42 cell division cycle 42
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CST4 cystatin S
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DIO2 deiodinase, iodothyronine, type II
DOK3 docking protein 3
EHD1 EH-domain containing 1
ELMO2 engulfment and cell motility 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXOC6B exocyst complex component 6B
FAM65A family with sequence similarity 65, member A
FLOT1 flotillin 1
FLOT2 flotillin 2
FRMD4A FERM domain containing 4A
FSCN3 fascin actin-bundling protein 3, testicular
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNS glucosamine (N-acetyl)-6-sulfatase
GPR157 G protein-coupled receptor 157
GPR21 G protein-coupled receptor 21
GRIP2 glutamate receptor interacting protein 2
HOXB9 homeobox B9
IFI35 interferon-induced protein 35
IGFBP5 insulin-like growth factor binding protein 5
INVS inversin
KDM6B lysine (K)-specific demethylase 6B
KERA keratocan
KLHL20 kelch-like family member 20
KLHL25 kelch-like family member 25
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LIMK2 LIM domain kinase 2
LIMS2 LIM and senescent cell antigen-like domains 2
LUZP4 leucine zipper protein 4
MAGEA1 melanoma antigen family A1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED20 mediator complex subunit 20
MEGF6 multiple EGF-like-domains 6
MOXD1 monooxygenase, DBH-like 1
MYF5 myogenic factor 5
MYOF myoferlin
MZF1 myeloid zinc finger 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUCB1 nucleobindin 1
OSMR oncostatin M receptor
OVOL1 ovo-like zinc finger 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PEX11A peroxisomal biogenesis factor 11 alpha
PHF7 PHD finger protein 7
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PKNOX2 PBX/knotted 1 homeobox 2
PMEL premelanosome protein
PRDM9 PR domain containing 9
PRPF31 pre-mRNA processing factor 31
PTPRR protein tyrosine phosphatase, receptor type, R
RARG retinoic acid receptor, gamma
REEP2 receptor accessory protein 2
RFXAP regulatory factor X-associated protein
RGL1 ral guanine nucleotide dissociation stimulator-like 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH3BP2 SH3-domain binding protein 2
SLC12A8 solute carrier family 12, member 8
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMAD1 SMAD family member 1
SPATA5L1 spermatogenesis associated 5-like 1
STAG3 stromal antigen 3
STEAP4 STEAP family member 4
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAS2R9 taste receptor, type 2, member 9
TCP10L t-complex 10-like
TGFB2 transforming growth factor, beta 2
TMPRSS3 transmembrane protease, serine 3
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TSHR thyroid stimulating hormone receptor
TTC38 tetratricopeptide repeat domain 38
UBA7 ubiquitin-like modifier activating enzyme 7
UBOX5 U-box domain containing 5
ZNF155 zinc finger protein 155
ZNF175 zinc finger protein 175

decreased expression

Symbol Name
AGO3 argonaute RISC catalytic component 3
BAGE B melanoma antigen
C16ORF62 chromosome 16 open reading frame 62
C1QTNF3 C1q and tumor necrosis factor related protein 3
C4ORF29 chromosome 4 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CAPN5 calpain 5
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC85C coiled-coil domain containing 85C
CENPO centromere protein O
CENPQ centromere protein Q
CRBN cereblon
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTNNBIP1 catenin, beta interacting protein 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DCAF17 DDB1 and CUL4 associated factor 17
DENND4A DENN/MADD domain containing 4A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DSCAM Down syndrome cell adhesion molecule
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXOC5 exocyst complex component 5
FCHSD2 FCH and double SH3 domains 2
FYCO1 FYVE and coiled-coil domain containing 1
FZD3 frizzled class receptor 3
GPR19 G protein-coupled receptor 19
GTF2I general transcription factor IIi
HHLA3 HERV-H LTR-associating 3
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX1 heme oxygenase 1
HPS6 Hermansky-Pudlak syndrome 6
HYAL2 hyaluronoglucosaminidase 2
IDI2-AS1 IDI2 antisense RNA 1
IL15RA interleukin 15 receptor, alpha
IL17RA interleukin 17 receptor A
INO80D INO80 complex subunit D
KIAA0753 KIAA0753
KIF16B kinesin family member 16B
KIFAP3 kinesin-associated protein 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIN7B lin-7 homolog B (C. elegans)
LINS lines homolog (Drosophila)
LMNB1 lamin B1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP9 microtubule-associated protein 9
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED15 mediator complex subunit 15
MICU2 mitochondrial calcium uptake 2
MNX1 motor neuron and pancreas homeobox 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYL5 myosin, light chain 5, regulatory
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRPH peripherin
RAI14 retinoic acid induced 14
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RIN2 Ras and Rab interactor 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL23AP32 ribosomal protein L23a pseudogene 32
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH2B3 SH2B adaptor protein 3
SKI SKI proto-oncogene
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A40 solute carrier family 25, member 40
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNAI2 snail family zinc finger 2
SNHG3 small nucleolar RNA host gene 3
SNORA21 small nucleolar RNA, H/ACA box 21
SPHK1 sphingosine kinase 1
SPIDR scaffolding protein involved in DNA repair
SREK1IP1 SREK1-interacting protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTN1 tectonic family member 1
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRABD TraB domain containing
TRIM36 tripartite motif containing 36
TRIM5 tripartite motif containing 5
UBQLN4 ubiquilin 4
UBXN8 UBX domain protein 8
WLS wntless Wnt ligand secretion mediator
XAB2 XPA binding protein 2
YIPF5 Yip1 domain family, member 5
ZC3H3 zinc finger CCCH-type containing 3
ZNF654 zinc finger protein 654