diffuse Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

436 genes co-occuring with the biological term diffuse in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTA2 actin, alpha 2, smooth muscle, aorta
ACVR1 activin A receptor, type I
ADAM15 ADAM metallopeptidase domain 15
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ADIPOQ adiponectin, C1Q and collagen domain containing
AHCY adenosylhomocysteinase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP12 A kinase (PRKA) anchor protein 12
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALK anaplastic lymphoma receptor tyrosine kinase
AMACR alpha-methylacyl-CoA racemase
ANO1 anoctamin 1, calcium activated chloride channel
ANXA10 annexin A10
ANXA2 annexin A2
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
AQP5 aquaporin 5
ATM ATM serine/threonine kinase
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAD BCL2-associated agonist of cell death
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BCL7A B-cell CLL/lymphoma 7A
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BLM Bloom syndrome, RecQ helicase-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1QTNF5 C1q and tumor necrosis factor related protein 5
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CA12 carbonic anhydrase XII
CA9 carbonic anhydrase IX
CAMTA1 calmodulin binding transcription activator 1
CARD11 caspase recruitment domain family, member 11
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CCL19 chemokine (C-C motif) ligand 19
CCNB1 cyclin B1
CCND1 cyclin D1
CCND3 cyclin D3
CCNE1 cyclin E1
CCNH cyclin H
CCR2 chemokine (C-C motif) receptor 2
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD27 CD27 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD5 CD5 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD99 CD99 molecule
CDA cytidine deaminase
CDC7 cell division cycle 7
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDX2 caudal type homeobox 2
CES2 carboxylesterase 2
CFAP69 cilia and flagella associated protein 69
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CIITA class II, major histocompatibility complex, transactivator
CLDN1 claudin 1
CLDN4 claudin 4
CNR2 cannabinoid receptor 2 (macrophage)
CNTN1 contactin 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSNK1A1 casein kinase 1, alpha 1
CT45A1 cancer/testis antigen family 45, member A1
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DIO1 deiodinase, iodothyronine, type I
DIO2 deiodinase, iodothyronine, type II
DMBT1 deleted in malignant brain tumors 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP4 dipeptidyl-peptidase 4
DUT deoxyuridine triphosphatase
DUX4L1 double homeobox 4 like 1
EBI3 Epstein-Barr virus induced 3
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FBXO10 F-box protein 10
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FHIT fragile histidine triad
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT4 fms-related tyrosine kinase 4
FMR1 fragile X mental retardation 1
FOXL2 forkhead box L2
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXP1 forkhead box P1
FOXP3 forkhead box P3
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GATA3 GATA binding protein 3
GBA glucosidase, beta, acid
GC group-specific component (vitamin D binding protein)
GCSAM germinal center-associated, signaling and motility
GFAP glial fibrillary acidic protein
GKN1 gastrokine 1
GKN2 gastrokine 2
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYPC glycophorin C (Gerbich blood group)
H2AFX H2A histone family, member X
H3F3A H3 histone, family 3A
HADH hydroxyacyl-CoA dehydrogenase
HAMP hepcidin antimicrobial peptide
HCAR2 hydroxycarboxylic acid receptor 2
HCAR3 hydroxycarboxylic acid receptor 3
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC6 histone deacetylase 6
HGFAC HGF activator
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
HIST4H4 histone cluster 4, H4
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HMGB1 high mobility group box 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA4 heat shock 70kDa protein 4
HTRA2 HtrA serine peptidase 2
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGH immunoglobulin heavy locus
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL21 interleukin 21
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IQGAP1 IQ motif containing GTPase activating protein 1
IRAK1 interleukin-1 receptor-associated kinase 1
IRF4 interferon regulatory factor 4
IRF8 interferon regulatory factor 8
ISL1 ISL LIM homeobox 1
IYD iodotyrosine deiodinase
JAK2 Janus kinase 2
KAT2B K(lysine) acetyltransferase 2B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDR kinase insert domain receptor
KDSR 3-ketodihydrosphingosine reductase
KIAA1549 KIAA1549
KIF21A kinesin family member 21A
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2D lysine (K)-specific methyltransferase 2D
KRT1 keratin 1, type II
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KRT9 keratin 9, type I
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LPP LIM domain containing preferred translocation partner in lipoma
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LY6D lymphocyte antigen 6 complex, locus D
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MALT1 MALT1 paracaspase
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4 microtubule-associated protein 4
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MEF2B myocyte enhancer factor 2B
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR127 microRNA 127
MIR142 microRNA 142
MIR146B microRNA 146b
MIR155 microRNA 155
MIR17 microRNA 17
MIR21 microRNA 21
MIR223 microRNA 223
MIR23A microRNA 23a
MIR24-1 microRNA 24-1
MIR28 microRNA 28
MIR320D1 microRNA 320d-1
MIR34A microRNA 34a
MIRLET7A1 microRNA let-7a-1
MKI67 marker of proliferation Ki-67
MLANA melan-A
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSC musculin
MSI1 musashi RNA-binding protein 1
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC22 mucin 22
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUM1 melanoma associated antigen (mutated) 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
MYOG myogenin (myogenic factor 4)
MZB1 marginal zone B and B1 cell-specific protein
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NCF1 neutrophil cytosolic factor 1
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NIPAL4 NIPA-like domain containing 4
NKX2-1 NK2 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH1 notch 1
NPC2 Niemann-Pick disease, type C2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUMA1 nuclear mitotic apparatus protein 1
OLIG2 oligodendrocyte lineage transcription factor 2
ONECUT2 one cut homeobox 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PAX2 paired box 2
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PECAM1 platelet/endothelial cell adhesion molecule 1
PEPD peptidase D
PGK1 phosphoglycerate kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PITX1 paired-like homeodomain 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCE1 phospholipase C, epsilon 1
PLK1 polo-like kinase 1
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRAME preferentially expressed antigen in melanoma
PRDM1 PR domain containing 1, with ZNF domain
PRDM2 PR domain containing 2, with ZNF domain
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCB protein kinase C, beta
PRNP prion protein
PRPH2 peripherin 2 (retinal degeneration, slow)
PSCA prostate stem cell antigen
PSEN1 presenilin 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAD50 RAD50 homolog (S. cerevisiae)
RANBP2 RAN binding protein 2
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOH ras homolog family member H
RIPK4 receptor-interacting serine-threonine kinase 4
RNF31 ring finger protein 31
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RTN3 reticulon 3
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
S100B S100 calcium binding protein B
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SBDS Shwachman-Bodian-Diamond syndrome
SDC1 syndecan 1
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
SETD2 SET domain containing 2
SFTPC surfactant protein C
SFTPD surfactant protein D
SHH sonic hedgehog
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIK2 salt-inducible kinase 2
SIRT1 sirtuin 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCB synuclein, beta
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOCS1 suppressor of cytokine signaling 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SSTR2 somatostatin receptor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TCL1A T-cell leukemia/lymphoma 1A
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TFF2 trefoil factor 2
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM3 transglutaminase 3
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TNIP2 TNFAIP3 interacting protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TREM1 triggering receptor expressed on myeloid cells 1
TSLP thymic stromal lymphopoietin
TTF1 transcription termination factor, RNA polymerase I
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
TXN thioredoxin
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XCL1 chemokine (C motif) ligand 1
XCR1 chemokine (C motif) receptor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZAR1 zygote arrest 1
ZEB1 zinc finger E-box binding homeobox 1