diflunisal-1490 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the diflunisal-1490 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANKRD12 ankyrin repeat domain 12
ARHGAP24 Rho GTPase activating protein 24
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATF7IP activating transcription factor 7 interacting protein
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCAN brevican
BIN1 bridging integrator 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C17ORF59 chromosome 17 open reading frame 59
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPN10 calpain 10
CD7 CD7 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
COL6A1 collagen, type VI, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPNE7 copine VII
CRTC1 CREB regulated transcription coactivator 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EVA1B eva-1 homolog B (C. elegans)
EXD3 exonuclease 3'-5' domain containing 3
FAM214B family with sequence similarity 214, member B
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GIF gastric intrinsic factor (vitamin B synthesis)
GPC3 glypican 3
HHAT hedgehog acyltransferase
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IGL immunoglobulin lambda locus
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM6A lysine (K)-specific demethylase 6A
LIME1 Lck interacting transmembrane adaptor 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
MBD1 methyl-CpG binding domain protein 1
MBNL2 muscleblind-like splicing regulator 2
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIIP migration and invasion inhibitory protein
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MKL1 megakaryoblastic leukemia (translocation) 1
MYBPC3 myosin binding protein C, cardiac
NADK NAD kinase
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOL10 nucleolar protein 10
NPTX2 neuronal pentraxin II
OLFML2B olfactomedin-like 2B
PCDH17 protocadherin 17
PCDHGA10 protocadherin gamma subfamily A, 10
PDE4C phosphodiesterase 4C, cAMP-specific
PDGFD platelet derived growth factor D
PHOX2A paired-like homeobox 2a
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PODNL1 podocan-like 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRODH proline dehydrogenase (oxidase) 1
PTHLH parathyroid hormone-like hormone
RAB27B RAB27B, member RAS oncogene family
RARA retinoic acid receptor, alpha
RPL35A ribosomal protein L35a
SCAPER S-phase cyclin A-associated protein in the ER
SCD5 stearoyl-CoA desaturase 5
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRR1B small proline-rich protein 1B
SRCAP Snf2-related CREBBP activator protein
SSTR4 somatostatin receptor 4
SSX1 synovial sarcoma, X breakpoint 1
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TMOD1 tropomodulin 1
TTC38 tetratricopeptide repeat domain 38
TUBA3C tubulin, alpha 3c
VEZT vezatin, adherens junctions transmembrane protein
VIPR2 vasoactive intestinal peptide receptor 2
WSCD1 WSC domain containing 1
XYLB xylulokinase homolog (H. influenzae)
ZBTB44 zinc finger and BTB domain containing 44
ZNF324 zinc finger protein 324
ZNF589 zinc finger protein 589
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADTRP androgen-dependent TFPI-regulating protein
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATAD2B ATPase family, AAA domain containing 2B
BRAF B-Raf proto-oncogene, serine/threonine kinase
C17ORF75 chromosome 17 open reading frame 75
C2CD2 C2 calcium-dependent domain containing 2
CAMTA1 calmodulin binding transcription activator 1
CBR4 carbonyl reductase 4
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CENPT centromere protein T
CGREF1 cell growth regulator with EF-hand domain 1
CHKB choline kinase beta
CHML choroideremia-like (Rab escort protein 2)
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CRY2 cryptochrome circadian clock 2
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNA2 DNA replication helicase/nuclease 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSCAM Down syndrome cell adhesion molecule
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM86C1 family with sequence similarity 86, member C1
FBXL6 F-box and leucine-rich repeat protein 6
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ22184
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD3 frizzled class receptor 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPALPP1 GPALPP motifs containing 1
GRTP1 growth hormone regulated TBC protein 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HIST1H2AI histone cluster 1, H2ai
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP6 insulin-like growth factor binding protein 6
IPO8 importin 8
IRF1 interferon regulatory factor 1
KCTD20 potassium channel tetramerization domain containing 20
KIFAP3 kinesin-associated protein 3
KLF11 Kruppel-like factor 11
LMBR1L limb development membrane protein 1-like
LOC730101 uncharacterized LOC730101
MAP6D1 MAP6 domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
METTL16 methyltransferase like 16
MORC3 MORC family CW-type zinc finger 3
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MXD3 MAX dimerization protein 3
MYO9A myosin IXA
NAV2 neuron navigator 2
NFE2L3 nuclear factor, erythroid 2-like 3
NPIPB15 nuclear pore complex interacting protein family, member B15
PCOLCE2 procollagen C-endopeptidase enhancer 2
PER3 period circadian clock 3
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLH polymerase (DNA directed), eta
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PTCD2 pentatricopeptide repeat domain 2
QSER1 glutamine and serine rich 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAD51D RAD51 paralog D
RFTN1 raftlin, lipid raft linker 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RP2 retinitis pigmentosa 2 (X-linked recessive)
SIX1 SIX homeobox 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNX16 sorting nexin 16
SOWAHC sosondowah ankyrin repeat domain family member C
SP1 Sp1 transcription factor
SPIDR scaffolding protein involved in DNA repair
SPRYD7 SPRY domain containing 7
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STK16 serine/threonine kinase 16
VPS9D1 VPS9 domain containing 1
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
WRAP73 WD repeat containing, antisense to TP73
XPC xeroderma pigmentosum, complementation group C
ZBTB39 zinc finger and BTB domain containing 39
ZNF34 zinc finger protein 34
ZNF350 zinc finger protein 350
ZNF423 zinc finger protein 423
ZNF428 zinc finger protein 428
ZNF573 zinc finger protein 573
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816