diflunisal-1990 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the diflunisal-1990 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AACS acetoacetyl-CoA synthetase
ACP6 acid phosphatase 6, lysophosphatidic
AHNAK AHNAK nucleoprotein
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ART1 ADP-ribosyltransferase 1
ATG13 autophagy related 13
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP9B ATPase, class II, type 9B
AXIN1 axin 1
BICD1 bicaudal D homolog 1 (Drosophila)
BPTF bromodomain PHD finger transcription factor
C22ORF24 chromosome 22 open reading frame 24
C6ORF106 chromosome 6 open reading frame 106
CBR4 carbonyl reductase 4
CCHCR1 coiled-coil alpha-helical rod protein 1
CCPG1 cell cycle progression 1
CDK12 cyclin-dependent kinase 12
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLIC4 chloride intracellular channel 4
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRNKL1 crooked neck pre-mRNA splicing factor 1
EFNA5 ephrin-A5
EGLN1 egl-9 family hypoxia-inducible factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA1 EPH receptor A1
EPHB3 EPH receptor B3
ERP44 endoplasmic reticulum protein 44
F11R F11 receptor
FAM134A family with sequence similarity 134, member A
FAM64A family with sequence similarity 64, member A
FCHSD2 FCH and double SH3 domains 2
FPR2 formyl peptide receptor 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GOSR1 golgi SNAP receptor complex member 1
GPATCH4 G patch domain containing 4
GPR183 G protein-coupled receptor 183
HIST3H2A histone cluster 3, H2a
HSPA9 heat shock 70kDa protein 9 (mortalin)
HUS1 HUS1 checkpoint homolog (S. pombe)
IL1RAP interleukin 1 receptor accessory protein
JRKL JRK-like
KIF3C kinesin family member 3C
KLHDC10 kelch domain containing 10
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRCC1 lysine-rich coiled-coil 1
LIN7C lin-7 homolog C (C. elegans)
LOC390998 ribosomal protein L10 pseudogene
LPIN2 lipin 2
MED14 mediator complex subunit 14
MGAM maltase-glucoamylase
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFX1 nuclear transcription factor, X-box binding 1
NRGN neurogranin (protein kinase C substrate, RC3)
OGFR opioid growth factor receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PARG poly (ADP-ribose) glycohydrolase
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDHB pyruvate dehydrogenase (lipoamide) beta
PLAA phospholipase A2-activating protein
PLD2 phospholipase D2
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPT2 palmitoyl-protein thioesterase 2
PRDX2 peroxiredoxin 2
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBM47 RNA binding motif protein 47
REEP4 receptor accessory protein 4
RGS1 regulator of G-protein signaling 1
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RUNDC3A RUN domain containing 3A
SCCPDH saccharopine dehydrogenase (putative)
SEC31B SEC31 homolog B (S. cerevisiae)
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
STK19 serine/threonine kinase 19
STX1A syntaxin 1A (brain)
SYN2 synapsin II
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFG TRK-fused gene
TGFB3 transforming growth factor, beta 3
TMEM57 transmembrane protein 57
U2AF2 U2 small nuclear RNA auxiliary factor 2
UFM1 ubiquitin-fold modifier 1
WASL Wiskott-Aldrich syndrome-like
WDR48 WD repeat domain 48
XYLT1 xylosyltransferase I
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF335 zinc finger protein 335
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ACOT8 acyl-CoA thioesterase 8
ADAM23 ADAM metallopeptidase domain 23
ADGRE5 adhesion G protein-coupled receptor E5
APH1B APH1B gamma secretase subunit
APOC2 apolipoprotein C-II
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARMC7 armadillo repeat containing 7
ASCC2 activating signal cointegrator 1 complex subunit 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD2B ATPase family, AAA domain containing 2B
BARD1 BRCA1 associated RING domain 1
C22ORF29 chromosome 22 open reading frame 29
C6ORF47 chromosome 6 open reading frame 47
CALCOCO2 calcium binding and coiled-coil domain 2
CCDC130 coiled-coil domain containing 130
CCNL2 cyclin L2
CDK5 cyclin-dependent kinase 5
CHMP1A charged multivesicular body protein 1A
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
COPS7B COP9 signalosome subunit 7B
DCTN4 dynactin 4 (p62)
DDIT3 DNA-damage-inducible transcript 3
DEXI Dexi homolog (mouse)
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DPF2 D4, zinc and double PHD fingers family 2
ELP5 elongator acetyltransferase complex subunit 5
FBXW4 F-box and WD repeat domain containing 4
GALE UDP-galactose-4-epimerase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJD2 gap junction protein, delta 2, 36kDa
GMPPB GDP-mannose pyrophosphorylase B
GPR27 G protein-coupled receptor 27
HIST1H1E histone cluster 1, H1e
HMGB3P1 high mobility group box 3 pseudogene 1
HNRNPF heterogeneous nuclear ribonucleoprotein F
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ISG15 ISG15 ubiquitin-like modifier
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA10 integrin, alpha 10
ITM2C integral membrane protein 2C
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0196 KIAA0196
KIAA0894 KIAA0894 protein
KRI1 KRI1 homolog (S. cerevisiae)
LIMD2 LIM domain containing 2
LSP1 lymphocyte-specific protein 1
MAPK3 mitogen-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPKBP1 mitogen-activated protein kinase binding protein 1
MOSPD3 motile sperm domain containing 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYO19 myosin XIX
NEK11 NIMA-related kinase 11
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEF1 penta-EF-hand domain containing 1
PEX26 peroxisomal biogenesis factor 26
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHO2 pleckstrin homology domain containing, family O member 2
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PTCD1 pentatricopeptide repeat domain 1
QPRT quinolinate phosphoribosyltransferase
RALY RALY heterogeneous nuclear ribonucleoprotein
RIC8A RIC8 guanine nucleotide exchange factor A
RNMTL1 RNA methyltransferase like 1
RPE ribulose-5-phosphate-3-epimerase
RPL39L ribosomal protein L39-like
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SATB1 SATB homeobox 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC25A40 solute carrier family 25, member 40
SMG9 SMG9 nonsense mediated mRNA decay factor
SP140L SP140 nuclear body protein-like
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAC SH3 and cysteine rich domain
STRA13 stimulated by retinoic acid 13
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLN1 talin 1
TMED1 transmembrane emp24 protein transport domain containing 1
TNRC6B trinucleotide repeat containing 6B
TRAC T cell receptor alpha constant
TRIM26 tripartite motif containing 26
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WDR46 WD repeat domain 46
WDR5B WD repeat domain 5B
XPA xeroderma pigmentosum, complementation group A
ZDHHC4 zinc finger, DHHC-type containing 4
ZNF282 zinc finger protein 282
ZNF85 zinc finger protein 85