digoxigenin-3060 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the digoxigenin-3060 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMACR alpha-methylacyl-CoA racemase
APC2 adenomatosis polyposis coli 2
AREG amphiregulin
ATF7IP activating transcription factor 7 interacting protein
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AVL9 AVL9 homolog (S. cerevisiase)
B9D2 B9 protein domain 2
BIRC3 baculoviral IAP repeat containing 3
BTBD18 BTB (POZ) domain containing 18
BTBD7 BTB (POZ) domain containing 7
BTG2 BTG family, member 2
C18ORF25 chromosome 18 open reading frame 25
C21ORF91 chromosome 21 open reading frame 91
C3AR1 complement component 3a receptor 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CDC14B cell division cycle 14B
CDH10 cadherin 10, type 2 (T2-cadherin)
CDKN2AIP CDKN2A interacting protein
CLCA1 chloride channel accessory 1
COL1A1 collagen, type I, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COPE coatomer protein complex, subunit epsilon
CPN2 carboxypeptidase N, polypeptide 2
CREM cAMP responsive element modulator
CTNND2 catenin (cadherin-associated protein), delta 2
DOK4 docking protein 4
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EPYC epiphycan
ERO1LB ERO1-like beta (S. cerevisiae)
ESR1 estrogen receptor 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD10 frizzled class receptor 10
GJA8 gap junction protein, alpha 8, 50kDa
GLP1R glucagon-like peptide 1 receptor
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRM1 glutamate receptor, metabotropic 1
HBEGF heparin-binding EGF-like growth factor
HIST1H1T histone cluster 1, H1t
HIST1H4C histone cluster 1, H4c
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-F major histocompatibility complex, class I, F
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRASLS2 HRAS-like suppressor 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL24 interleukin 24
IL6ST interleukin 6 signal transducer
IMPG2 interphotoreceptor matrix proteoglycan 2
KRT10 keratin 10, type I
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFYA nuclear transcription factor Y, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP188 nucleoporin 188kDa
NUPL1 nucleoporin like 1
OVGP1 oviductal glycoprotein 1, 120kDa
PAX8 paired box 8
PDE4B phosphodiesterase 4B, cAMP-specific
PKP3 plakophilin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PTX3 pentraxin 3, long
RBM4 RNA binding motif protein 4
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBG Rh family, B glycoprotein (gene/pseudogene)
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
RUNX1 runt-related transcription factor 1
SERHL2 serine hydrolase-like 2
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLMO1 slowmo homolog 1 (Drosophila)
SMC4 structural maintenance of chromosomes 4
SPRY4 sprouty homolog 4 (Drosophila)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TBX5 T-box 5
THBS1 thrombospondin 1
THSD7A thrombospondin, type I, domain containing 7A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM38 tripartite motif containing 38
TXNIP thioredoxin interacting protein
UBAP1 ubiquitin associated protein 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZBTB40 zinc finger and BTB domain containing 40
ZNF335 zinc finger protein 335
ZNF528 zinc finger protein 528

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ADM adrenomedullin
ASB13 ankyrin repeat and SOCS box containing 13
C1ORF106 chromosome 1 open reading frame 106
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBR1 carbonyl reductase 1
CBR4 carbonyl reductase 4
CCNE2 cyclin E2
CD69 CD69 molecule
CDC7 cell division cycle 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CEL carboxyl ester lipase
CHST10 carbohydrate sulfotransferase 10
COA7 cytochrome c oxidase assembly factor 7 (putative)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDIT4 DNA-damage-inducible transcript 4
DET1 de-etiolated homolog 1 (Arabidopsis)
FANCF Fanconi anemia, complementation group F
FANCL Fanconi anemia, complementation group L
FPGT fucose-1-phosphate guanylyltransferase
GEMIN4 gem (nuclear organelle) associated protein 4
GPALPP1 GPALPP motifs containing 1
HEATR3 HEAT repeat containing 3
INHBE inhibin, beta E
INPP1 inositol polyphosphate-1-phosphatase
JRKL JRK-like
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD20 potassium channel tetramerization domain containing 20
KEAP1 kelch-like ECH-associated protein 1
KLF11 Kruppel-like factor 11
KRCC1 lysine-rich coiled-coil 1
LINC00339 long intergenic non-protein coding RNA 339
LINC00341 long intergenic non-protein coding RNA 341
LTB lymphotoxin beta (TNF superfamily, member 3)
MAT2A methionine adenosyltransferase II, alpha
MKKS McKusick-Kaufman syndrome
MOCS2 molybdenum cofactor synthesis 2
MORC2 MORC family CW-type zinc finger 2
MRPL17 mitochondrial ribosomal protein L17
MSRB1 methionine sulfoxide reductase B1
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAGK N-acetylglucosamine kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NTHL1 nth endonuclease III-like 1 (E. coli)
NTSR1 neurotensin receptor 1 (high affinity)
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PAAF1 proteasomal ATPase-associated factor 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDZD7 PDZ domain containing 7
PEX11B peroxisomal biogenesis factor 11 beta
PEX12 peroxisomal biogenesis factor 12
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLEKHO1 pleckstrin homology domain containing, family O member 1
POGK pogo transposable element with KRAB domain
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRDM13 PR domain containing 13
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRR3 proline rich 3
PTCD2 pentatricopeptide repeat domain 2
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOBTB1 Rho-related BTB domain containing 1
RPP40 ribonuclease P/MRP 40kDa subunit
RSAD1 radical S-adenosyl methionine domain containing 1
S100PBP S100P binding protein
SCO2 SCO2 cytochrome c oxidase assembly protein
SCRN3 secernin 3
SGMS1 sphingomyelin synthase 1
SLITRK5 SLIT and NTRK-like family, member 5
SOBP sine oculis binding protein homolog (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STARD7 StAR-related lipid transfer (START) domain containing 7
TEC tec protein tyrosine kinase
TFB1M transcription factor B1, mitochondrial
TGIF1 TGFB-induced factor homeobox 1
TGM5 transglutaminase 5
TMEM177 transmembrane protein 177
TMEM45A transmembrane protein 45A
TRIB3 tribbles pseudokinase 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WDR3 WD repeat domain 3
WDR5B WD repeat domain 5B
ZBED8 zinc finger, BED-type containing 8
ZNF141 zinc finger protein 141
ZNF232 zinc finger protein 232
ZNF248 zinc finger protein 248
ZNF345 zinc finger protein 345
ZNF529 zinc finger protein 529
ZNF573 zinc finger protein 573
ZNF7 zinc finger protein 7