digoxin-5324 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
Similar Terms
Downloads & Tools

Genes

199 genes differentially expressed following the digoxin-5324 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP9 A kinase (PRKA) anchor protein 9
AKIRIN1 akirin 1
AMOTL2 angiomotin like 2
ARID4A AT rich interactive domain 4A (RBP1-like)
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
AVPI1 arginine vasopressin-induced 1
BCL6 B-cell CLL/lymphoma 6
CCNL1 cyclin L1
CCNT1 cyclin T1
CCNT2 cyclin T2
CDKN2AIP CDKN2A interacting protein
CGA glycoprotein hormones, alpha polypeptide
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
ENSA endosulfine alpha
EPHA2 EPH receptor A2
ETNK1 ethanolamine kinase 1
EWSR1 EWS RNA-binding protein 1
FAM193A family with sequence similarity 193, member A
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
GTF2B general transcription factor IIB
HBP1 HMG-box transcription factor 1
HCFC2 host cell factor C2
HIST1H1T histone cluster 1, H1t
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HOXC13 homeobox C13
IER2 immediate early response 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IP6K2 inositol hexakisphosphate kinase 2
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCL1 myeloid cell leukemia 1
MORC3 MORC family CW-type zinc finger 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OVOL1 ovo-like zinc finger 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PUM1 pumilio RNA-binding family member 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM5 RNA binding motif protein 5
RLF rearranged L-myc fusion
RSRC2 arginine/serine-rich coiled-coil 2
SERTAD3 SERTA domain containing 3
SFPQ splicing factor proline/glutamine-rich
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
STX3 syntaxin 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
UBXN7 UBX domain protein 7
VEZF1 vascular endothelial zinc finger 1
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
ZBTB17 zinc finger and BTB domain containing 17
ZBTB40 zinc finger and BTB domain containing 40
ZC3H11A zinc finger CCCH-type containing 11A
ZFP36 ZFP36 ring finger protein
ZMYM5 zinc finger, MYM-type 5
ZNF292 zinc finger protein 292
ZNF335 zinc finger protein 335
ZNF430 zinc finger protein 430
ZNF654 zinc finger protein 654

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ADORA2B adenosine A2b receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKRD46 ankyrin repeat domain 46
ARMCX1 armadillo repeat containing, X-linked 1
ASB13 ankyrin repeat and SOCS box containing 13
BBX bobby sox homolog (Drosophila)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C11ORF68 chromosome 11 open reading frame 68
C14ORF169 chromosome 14 open reading frame 169
C17ORF75 chromosome 17 open reading frame 75
CANT1 calcium activated nucleotidase 1
CETN3 centrin, EF-hand protein, 3
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAAF2 dynein, axonemal, assembly factor 2
DUS2 dihydrouridine synthase 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EMC2 ER membrane protein complex subunit 2
FADD Fas (TNFRSF6)-associated via death domain
FAM114A2 family with sequence similarity 114, member A2
FAM86B1 family with sequence similarity 86, member B1
FANCF Fanconi anemia, complementation group F
FANCL Fanconi anemia, complementation group L
FBXL4 F-box and leucine-rich repeat protein 4
FYCO1 FYVE and coiled-coil domain containing 1
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GOLGA5 golgin A5
GPALPP1 GPALPP motifs containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HIRA histone cell cycle regulator
HPS6 Hermansky-Pudlak syndrome 6
ICT1 immature colon carcinoma transcript 1
IFI6 interferon, alpha-inducible protein 6
KIAA0753 KIAA0753
KRCC1 lysine-rich coiled-coil 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC8D leucine rich repeat containing 8 family, member D
MAT2A methionine adenosyltransferase II, alpha
MCRS1 microspherule protein 1
METTL13 methyltransferase like 13
METTL4 methyltransferase like 4
MKKS McKusick-Kaufman syndrome
MORC2 MORC family CW-type zinc finger 2
MRPL39 mitochondrial ribosomal protein L39
MTMR6 myotubularin related protein 6
OCEL1 occludin/ELL domain containing 1
ORC3 origin recognition complex, subunit 3
PAAF1 proteasomal ATPase-associated factor 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PDCD5 programmed cell death 5
PLK2 polo-like kinase 2
POGK pogo transposable element with KRAB domain
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRMT7 protein arginine methyltransferase 7
PRR3 proline rich 3
RAB20 RAB20, member RAS oncogene family
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOBTB1 Rho-related BTB domain containing 1
RPP40 ribonuclease P/MRP 40kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSAD1 radical S-adenosyl methionine domain containing 1
S100PBP S100P binding protein
SACS sacsin molecular chaperone
SCO2 SCO2 cytochrome c oxidase assembly protein
SEH1L SEH1-like (S. cerevisiae)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPC25 SPC25, NDC80 kinetochore complex component
STARD7 StAR-related lipid transfer (START) domain containing 7
TARBP1 TAR (HIV-1) RNA binding protein 1
TFB1M transcription factor B1, mitochondrial
THYN1 thymocyte nuclear protein 1
TRAF5 TNF receptor-associated factor 5
TRIM16 tripartite motif containing 16
TRIM27 tripartite motif containing 27
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBL4A ubiquitin-like 4A
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR3 WD repeat domain 3
WDR5B WD repeat domain 5B
XBP1 X-box binding protein 1
ZBED8 zinc finger, BED-type containing 8
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZIC1 Zic family member 1
ZNF23 zinc finger protein 23
ZNF7 zinc finger protein 7
ZNF83 zinc finger protein 83