digoxin Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	Digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small. (Chemical Entities of Biological Interest Ontology, CHEBI_4551)
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Genes

11 genes co-occuring with the biological term digoxin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
CYP3A	cytochrome P450, family 3, subfamily A
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
RGS2	regulator of G-protein signaling 2
SLCO1A2	solute carrier organic anion transporter family, member 1A2
SLCO1B1	solute carrier organic anion transporter family, member 1B1
SLCO1B3	solute carrier organic anion transporter family, member 1B3
SLCO2B1	solute carrier organic anion transporter family, member 2B1
SLCO4C1	solute carrier organic anion transporter family, member 4C1
TOP1	topoisomerase (DNA) I
TOP2A	topoisomerase (DNA) II alpha 170kDa