dihydropyrimidine dehydrogenase deficiency Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine. (Human Disease Ontology, DOID_14218)
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27 genes co-occuring with the disease dihydropyrimidine dehydrogenase deficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DPYD dihydropyrimidine dehydrogenase 2.33394
DPYS dihydropyrimidinase 1.90381
ADSL adenylosuccinate lyase 1.41753
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.03156
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.94369
LPPR4 lipid phosphate phosphatase-related protein type 4 0.893359
GPSM2 G-protein signaling modulator 2 0.702732
XDH xanthine dehydrogenase 0.671925
APRT adenine phosphoribosyltransferase 0.645375
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.614747
CHIT1 chitinase 1 (chitotriosidase) 0.526904
TPMT thiopurine S-methyltransferase 0.521502
RRM1 ribonucleotide reductase M1 0.501909
EML4 echinoderm microtubule associated protein like 4 0.493885
KLF4 Kruppel-like factor 4 (gut) 0.442418
MITF microphthalmia-associated transcription factor 0.408666
NT5E 5'-nucleotidase, ecto (CD73) 0.363347
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.350452
TYMP thymidine phosphorylase 0.344574
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.340539
VAV3 vav 3 guanine nucleotide exchange factor 0.317545
DLG1 discs, large homolog 1 (Drosophila) 0.304503
KRAS Kirsten rat sarcoma viral oncogene homolog 0.295851
HRAS Harvey rat sarcoma viral oncogene homolog 0.243995
HLA-DOB major histocompatibility complex, class II, DO beta 0.197742
G6PD glucose-6-phosphate dehydrogenase 0.191097
COL11A1 collagen, type XI, alpha 1 0.177301