dihydrostreptomycin-1391 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dihydrostreptomycin-1391 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
APAF1 apoptotic peptidase activating factor 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGAP32 Rho GTPase activating protein 32
ARTN artemin
ATAD2B ATPase family, AAA domain containing 2B
B3GNT1
BCL7C B-cell CLL/lymphoma 7C
C10ORF12 chromosome 10 open reading frame 12
C2CD2L C2CD2-like
C3AR1 complement component 3a receptor 1
CACFD1 calcium channel flower domain containing 1
CADM3 cell adhesion molecule 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC64 coiled-coil domain containing 64
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEND1 cell cycle exit and neuronal differentiation 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CRY2 cryptochrome circadian clock 2
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
DCAF15 DDB1 and CUL4 associated factor 15
DDHD2 DDHD domain containing 2
DLK2 delta-like 2 homolog (Drosophila)
E2F4 E2F transcription factor 4, p107/p130-binding
ECHDC2 enoyl CoA hydratase domain containing 2
EML2 echinoderm microtubule associated protein like 2
EPS8L1 EPS8-like 1
FAM162A family with sequence similarity 162, member A
FAM178A family with sequence similarity 178, member A
FTO fat mass and obesity associated
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GOLGA1 golgin A1
GP9 glycoprotein IX (platelet)
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRB7 growth factor receptor-bound protein 7
GRIP2 glutamate receptor interacting protein 2
HBB hemoglobin, beta
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXC11 homeobox C11
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITSN1 intersectin 1 (SH3 domain protein)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LBP lipopolysaccharide binding protein
LPP LIM domain containing preferred translocation partner in lipoma
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK13 mitogen-activated protein kinase 13
MAST2 microtubule associated serine/threonine kinase 2
MBTD1 mbt domain containing 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED14 mediator complex subunit 14
MED16 mediator complex subunit 16
MFSD7 major facilitator superfamily domain containing 7
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PADI2 peptidyl arginine deiminase, type II
PGC progastricsin (pepsinogen C)
PIAS4 protein inhibitor of activated STAT, 4
PLCL2 phospholipase C-like 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PRDM11 PR domain containing 11
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRPH peripherin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RET ret proto-oncogene
RGS12 regulator of G-protein signaling 12
RHOH ras homolog family member H
RUNDC3A RUN domain containing 3A
RUNX1 runt-related transcription factor 1
SAP30 Sin3A-associated protein, 30kDa
SERBP1 SERPINE1 mRNA binding protein 1
SHROOM2 shroom family member 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMG5 SMG5 nonsense mediated mRNA decay factor
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SYT13 synaptotagmin XIII
TCL1A T-cell leukemia/lymphoma 1A
TEAD4 TEA domain family member 4
TFEC transcription factor EC
TGM5 transglutaminase 5
THRB thyroid hormone receptor, beta
TK2 thymidine kinase 2, mitochondrial
TLK2 tousled-like kinase 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
UBOX5 U-box domain containing 5
URM1 ubiquitin related modifier 1
USP34 ubiquitin specific peptidase 34
ZNF460 zinc finger protein 460
ZNF747 zinc finger protein 747
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2A activin A receptor, type IIA
ADRB2 adrenoceptor beta 2, surface
ARMCX5 armadillo repeat containing, X-linked 5
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATXN2 ataxin 2
BMS1 BMS1 ribosome biogenesis factor
C1D C1D nuclear receptor corepressor
C8ORF33 chromosome 8 open reading frame 33
CALCOCO1 calcium binding and coiled-coil domain 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC130 coiled-coil domain containing 130
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CLTCL1 clathrin, heavy chain-like 1
CREG1 cellular repressor of E1A-stimulated genes 1
DERA deoxyribose-phosphate aldolase (putative)
DOK2 docking protein 2, 56kDa
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ECD ecdysoneless homolog (Drosophila)
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ERGIC2 ERGIC and golgi 2
EVL Enah/Vasp-like
EXOSC10 exosome component 10
F13A1 coagulation factor XIII, A1 polypeptide
FBXL4 F-box and leucine-rich repeat protein 4
FBXO5 F-box protein 5
GBAP1 glucosidase, beta, acid pseudogene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HIST3H2A histone cluster 3, H2a
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGN3 high mobility group nucleosomal binding domain 3
IL4R interleukin 4 receptor
KCTD9 potassium channel tetramerization domain containing 9
KIAA0196 KIAA0196
KLHL21 kelch-like family member 21
LTB lymphotoxin beta (TNF superfamily, member 3)
MAD2L1BP MAD2L1 binding protein
MAEA macrophage erythroblast attacher
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPHOSPH6 M-phase phosphoprotein 6
MRPS15 mitochondrial ribosomal protein S15
MTCH2 mitochondrial carrier 2
MTG1 mitochondrial ribosome-associated GTPase 1
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NAP1L4 nucleosome assembly protein 1-like 4
NCF1C neutrophil cytosolic factor 1C pseudogene
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NRGN neurogranin (protein kinase C substrate, RC3)
OARD1 O-acyl-ADP-ribose deacylase 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PMS2P5 postmeiotic segregation increased 2 pseudogene 5
PRRC1 proline-rich coiled-coil 1
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN1 Ras and Rab interactor 1
RIT1 Ras-like without CAAX 1
SARAF store-operated calcium entry-associated regulatory factor
SERTAD3 SERTA domain containing 3
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMAD7 SMAD family member 7
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNX15 sorting nexin 15
SRBD1 S1 RNA binding domain 1
STAU2 staufen double-stranded RNA binding protein 2
STK25 serine/threonine kinase 25
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBL3 transducin (beta)-like 3
THOC1 THO complex 1
TJP2 tight junction protein 2
TLN1 talin 1
TRIB1 tribbles pseudokinase 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSLIG2 tRNA splicing ligase complex subunit 2
TST thiosulfate sulfurtransferase (rhodanese)
TTI1 TELO2 interacting protein 1
UBA5 ubiquitin-like modifier activating enzyme 5
UCKL1 uridine-cytidine kinase 1-like 1
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
WDR18 WD repeat domain 18
WDR47 WD repeat domain 47
YIPF1 Yip1 domain family, member 1
YY2 YY2 transcription factor
ZBTB48 zinc finger and BTB domain containing 48
ZCCHC8 zinc finger, CCHC domain containing 8
ZW10 zw10 kinetochore protein