dihydrostreptomycin-2074 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the dihydrostreptomycin-2074 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD12 ankyrin repeat domain 12
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BBIP1 BBSome interacting protein 1
BMP4 bone morphogenetic protein 4
C1ORF105 chromosome 1 open reading frame 105
C9ORF40 chromosome 9 open reading frame 40
CALD1 caldesmon 1
CDK13 cyclin-dependent kinase 13
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLCN7 chloride channel, voltage-sensitive 7
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CREM cAMP responsive element modulator
DLK2 delta-like 2 homolog (Drosophila)
DSCR3 Down syndrome critical region 3
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EDNRA endothelin receptor type A
EFNB1 ephrin-B1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELF2 E74-like factor 2 (ets domain transcription factor)
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHB3 EPH receptor B3
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FCF1 FCF1 rRNA-processing protein
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXA2 forkhead box A2
FZD1 frizzled class receptor 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GOSR2 golgi SNAP receptor complex member 2
HEG1 heart development protein with EGF-like domains 1
HK2 hexokinase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI6 interferon, alpha-inducible protein 6
IL27RA interleukin 27 receptor, alpha
ITGB5 integrin, beta 5
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM4D lysine (K)-specific demethylase 4D
KIAA1644 KIAA1644
LINC00094 long intergenic non-protein coding RNA 94
LRRC41 leucine rich repeat containing 41
MANBA mannosidase, beta A, lysosomal
MARK4 MAP/microtubule affinity-regulating kinase 4
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCTP1 multiple C2 domains, transmembrane 1
MIIP migration and invasion inhibitory protein
MRPL52 mitochondrial ribosomal protein L52
MYRF myelin regulatory factor
NADK NAD kinase
NCAPH2 non-SMC condensin II complex, subunit H2
NPIPB15 nuclear pore complex interacting protein family, member B15
NRG2 neuregulin 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PEX11A peroxisomal biogenesis factor 11 alpha
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PNISR PNN-interacting serine/arginine-rich protein
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRR16 proline rich 16
PSD3 pleckstrin and Sec7 domain containing 3
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RBBP9 retinoblastoma binding protein 9
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAGB Ras-related GTP binding B
SAYSD1 SAYSVFN motif domain containing 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SETD8 SET domain containing (lysine methyltransferase) 8
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAP23 synaptosomal-associated protein, 23kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
SUGP1 SURP and G patch domain containing 1
TEX261 testis expressed 261
TFEB transcription factor EB
TLK1 tousled-like kinase 1
TMEM159 transmembrane protein 159
TRIM66 tripartite motif containing 66
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSKU tsukushi, small leucine rich proteoglycan
TUSC3 tumor suppressor candidate 3
UBQLN4 ubiquilin 4
VEGFA vascular endothelial growth factor A
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDFY3 WD repeat and FYVE domain containing 3
WDHD1 WD repeat and HMG-box DNA binding protein 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF224 zinc finger protein 224
ZNF286A zinc finger protein 286A
ZNF426 zinc finger protein 426
ZNF552 zinc finger protein 552
ZNF614 zinc finger protein 614
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD8 abhydrolase domain containing 8
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADCY6 adenylate cyclase 6
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APH1B APH1B gamma secretase subunit
APOL6 apolipoprotein L, 6
ATF7IP2 activating transcription factor 7 interacting protein 2
BCORL1 BCL6 corepressor-like 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C16ORF59 chromosome 16 open reading frame 59
CBY1 chibby homolog 1 (Drosophila)
CCDC85C coiled-coil domain containing 85C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42SE1 CDC42 small effector 1
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CLIC3 chloride intracellular channel 3
CNGB3 cyclic nucleotide gated channel beta 3
COBL cordon-bleu WH2 repeat protein
COG7 component of oligomeric golgi complex 7
CPTP ceramide-1-phosphate transfer protein
CTC1 CTS telomere maintenance complex component 1
DNAL4 dynein, axonemal, light chain 4
DNM3 dynamin 3
ECM1 extracellular matrix protein 1
EGF epidermal growth factor
FAM127B family with sequence similarity 127, member B
FAM53B family with sequence similarity 53, member B
FBXL15 F-box and leucine-rich repeat protein 15
FMO4 flavin containing monooxygenase 4
FPGS folylpolyglutamate synthase
GALT galactose-1-phosphate uridylyltransferase
GAMT guanidinoacetate N-methyltransferase
GPR1 G protein-coupled receptor 1
HIST1H3G histone cluster 1, H3g
HYAL3 hyaluronoglucosaminidase 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT54 intraflagellar transport 54
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KDM5C lysine (K)-specific demethylase 5C
KIAA1549L KIAA1549-like
KLHL26 kelch-like family member 26
KRT33A keratin 33A, type I
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP6D1 MAP6 domain containing 1
MFGE8 milk fat globule-EGF factor 8 protein
MMP13 matrix metallopeptidase 13
MUC3B mucin 3B, cell surface associated
NOTCH1 notch 1
NPDC1 neural proliferation, differentiation and control, 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PARD6A par-6 family cell polarity regulator alpha
PC pyruvate carboxylase
PDGFRL platelet-derived growth factor receptor-like
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POMT2 protein-O-mannosyltransferase 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPT2 palmitoyl-protein thioesterase 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB3A RAB3A, member RAS oncogene family
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RHOC ras homolog family member C
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SESN1 sestrin 1
SH2D2A SH2 domain containing 2A
SLC35F6 solute carrier family 35, member F6
SLC46A3 solute carrier family 46, member 3
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNORA21 small nucleolar RNA, H/ACA box 21
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3 stromal antigen 3
SYT17 synaptotagmin XVII
TEAD3 TEA domain family member 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNS2 tensin 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM21 tripartite motif containing 21
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA3D tubulin, alpha 3d
UBTD1 ubiquitin domain containing 1
VEZT vezatin, adherens junctions transmembrane protein
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR91 WD repeat domain 91
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZMYM3 zinc finger, MYM-type 3
ZNF276 zinc finger protein 276
ZNF37BP zinc finger protein 37B, pseudogene
ZNF580 zinc finger protein 580