dihydrostreptomycin-2237 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dihydrostreptomycin-2237 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADAM12 ADAM metallopeptidase domain 12
ADAM19 ADAM metallopeptidase domain 19
ALDOB aldolase B, fructose-bisphosphate
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARL4D ADP-ribosylation factor-like 4D
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD248 CD248 molecule, endosialin
CDHR2 cadherin-related family member 2
CFAP45 cilia and flagella associated protein 45
COL1A1 collagen, type I, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CRTC1 CREB regulated transcription coactivator 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEFA4 defensin, alpha 4, corticostatin
DGCR2 DiGeorge syndrome critical region gene 2
DGCR8 DGCR8 microprocessor complex subunit
DOK4 docking protein 4
EDN1 endothelin 1
EFR3B EFR3 homolog B (S. cerevisiae)
FAM155B family with sequence similarity 155, member B
FAM76A family with sequence similarity 76, member A
FBLN1 fibulin 1
FKRP fukutin related protein
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS7 growth arrest-specific 7
GGTLC1 gamma-glutamyltransferase light chain 1
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR137 G protein-coupled receptor 137
GSK3A glycogen synthase kinase 3 alpha
GSTP1 glutathione S-transferase pi 1
HBEGF heparin-binding EGF-like growth factor
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIST1H1E histone cluster 1, H1e
IFT27 intraflagellar transport 27
IGL immunoglobulin lambda locus
IHH indian hedgehog
IL11RA interleukin 11 receptor, alpha
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPKA inositol-trisphosphate 3-kinase A
KAT6A K(lysine) acetyltransferase 6A
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KEL Kell blood group, metallo-endopeptidase
KIAA0125 KIAA0125
KIF25-AS1 KIF25 antisense RNA 1
LAT2 linker for activation of T cells family, member 2
LDLRAD4 low density lipoprotein receptor class A domain containing 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAPK7 mitogen-activated protein kinase 7
MARK2 MAP/microtubule affinity-regulating kinase 2
MED25 mediator complex subunit 25
MKL1 megakaryoblastic leukemia (translocation) 1
MTCP1 mature T-cell proliferation 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NME5 NME/NM23 family member 5
NT5M 5',3'-nucleotidase, mitochondrial
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PEG10 paternally expressed 10
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLCD1 phospholipase C, delta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POU4F2 POU class 4 homeobox 2
PTCRA pre T-cell antigen receptor alpha
RBM5 RNA binding motif protein 5
RBMS2 RNA binding motif, single stranded interacting protein 2
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A8 S100 calcium binding protein A8
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SH3BP2 SH3-domain binding protein 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SPAG8 sperm associated antigen 8
SPRY4 sprouty homolog 4 (Drosophila)
SRPK3 SRSF protein kinase 3
SSX3 synovial sarcoma, X breakpoint 3
SUGP1 SURP and G patch domain containing 1
TCF12 transcription factor 12
TFEB transcription factor EB
TFR2 transferrin receptor 2
TGFB2 transforming growth factor, beta 2
TNS1 tensin 1
TRD T cell receptor delta locus
TRIM29 tripartite motif containing 29
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM8 transient receptor potential cation channel, subfamily M, member 8
UPK2 uroplakin 2
USH2A Usher syndrome 2A (autosomal recessive, mild)
YPEL1 yippee-like 1 (Drosophila)
ZNF407 zinc finger protein 407
ZNF702P zinc finger protein 702, pseudogene

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ADAP2 ArfGAP with dual PH domains 2
ANKRD7 ankyrin repeat domain 7
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMC4 armadillo repeat containing 4
ATAT1 alpha tubulin acetyltransferase 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BMP15 bone morphogenetic protein 15
C14ORF93 chromosome 14 open reading frame 93
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C21ORF91 chromosome 21 open reading frame 91
C2ORF27A chromosome 2 open reading frame 27A
CCDC186 coiled-coil domain containing 186
CCDC71 coiled-coil domain containing 71
CD3D CD3d molecule, delta (CD3-TCR complex)
CD83 CD83 molecule
CDK3 cyclin-dependent kinase 3
CHML choroideremia-like (Rab escort protein 2)
COL9A2 collagen, type IX, alpha 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DOK5 docking protein 5
DPY19L1P1 DPY19L1 pseudogene 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL7 EGF-like-domain, multiple 7
ERCC6 excision repair cross-complementation group 6
FADS2 fatty acid desaturase 2
FAM160B2 family with sequence similarity 160, member B2
FOXN2 forkhead box N2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GJA9 gap junction protein, alpha 9, 59kDa
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR143 G protein-coupled receptor 143
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIRA histone cell cycle regulator
HIST1H3B histone cluster 1, H3b
HIST1H3E histone cluster 1, H3e
HMG20A high mobility group 20A
IFT54 intraflagellar transport 54
IPO8 importin 8
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KLHL25 kelch-like family member 25
KRI1 KRI1 homolog (S. cerevisiae)
LOC390998 ribosomal protein L10 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEB2 melanoma antigen family B2
MED9 mediator complex subunit 9
MMP2 matrix metallopeptidase 2
MPHOSPH8 M-phase phosphoprotein 8
MST1 macrophage stimulating 1
MT1HL1 metallothionein 1H-like 1
MVP major vault protein
NEUROD4 neuronal differentiation 4
NPFFR1 neuropeptide FF receptor 1
NSD1 nuclear receptor binding SET domain protein 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PAIP2B poly(A) binding protein interacting protein 2B
PEX26 peroxisomal biogenesis factor 26
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLA2G3 phospholipase A2, group III
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PODNL1 podocan-like 1
POM121 POM121 transmembrane nucleoporin
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
QPCTL glutaminyl-peptide cyclotransferase-like
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN2 Ras and Rab interactor 2
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPON2 spondin 2, extracellular matrix protein
STAB2 stabilin 2
STX1A syntaxin 1A (brain)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM8B transmembrane protein 8B
TMLHE trimethyllysine hydroxylase, epsilon
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSPAN2 tetraspanin 2
TUBA3C tubulin, alpha 3c
UNC119 unc-119 homolog (C. elegans)
VASH2 vasohibin 2
WNT10B wingless-type MMTV integration site family, member 10B
ZNF204P zinc finger protein 204, pseudogene
ZNF286A zinc finger protein 286A