dilazep-4688 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the dilazep-4688 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRG2 adhesion G protein-coupled receptor G2
AFF1 AF4/FMR2 family, member 1
AGFG1 ArfGAP with FG repeats 1
AMPH amphiphysin
APOLD1 apolipoprotein L domain containing 1
ARL2BP ADP-ribosylation factor-like 2 binding protein
ATF6B activating transcription factor 6 beta
C1ORF54 chromosome 1 open reading frame 54
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC186 coiled-coil domain containing 186
CCNG2 cyclin G2
CDC25C cell division cycle 25C
CEP112 centrosomal protein 112kDa
CLSTN2 calsyntenin 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CTSK cathepsin K
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNA1 ephrin-A1
FBXO21 F-box protein 21
FRMD1 FERM domain containing 1
GAS7 growth arrest-specific 7
GLS glutaminase
HBEGF heparin-binding EGF-like growth factor
HEXIM1 hexamethylene bis-acetamide inducible 1
HGD homogentisate 1,2-dioxygenase
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HOXB2 homeobox B2
IGFBP5 insulin-like growth factor binding protein 5
IL1RAP interleukin 1 receptor accessory protein
ING4 inhibitor of growth family, member 4
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF2 Kruppel-like factor 2
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
LIG3 ligase III, DNA, ATP-dependent
LMO2 LIM domain only 2 (rhombotin-like 1)
LPIN1 lipin 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCAM melanoma cell adhesion molecule
MVD mevalonate (diphospho) decarboxylase
N4BP2L2 NEDD4 binding protein 2-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NPFF neuropeptide FF-amide peptide precursor
NPR1 natriuretic peptide receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP88 nucleoporin 88kDa
NXN nucleoredoxin
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCLO piccolo presynaptic cytomatrix protein
PDE4DIP phosphodiesterase 4D interacting protein
PER1 period circadian clock 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCE1 phospholipase C, epsilon 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRDM2 PR domain containing 2, with ZNF domain
PTH1R parathyroid hormone 1 receptor
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCAPER S-phase cyclin A-associated protein in the ER
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERHL2 serine hydrolase-like 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT4 sirtuin 4
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC45A2 solute carrier family 45, member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMIM7 small integral membrane protein 7
SNED1 sushi, nidogen and EGF-like domains 1
TCF3 transcription factor 3
TCP11L1 t-complex 11, testis-specific-like 1
TRIM36 tripartite motif containing 36
TUFT1 tuftelin 1
UBOX5 U-box domain containing 5
USP46 ubiquitin specific peptidase 46
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YIPF4 Yip1 domain family, member 4
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRE5 adhesion G protein-coupled receptor E5
ALPK1 alpha-kinase 1
ARC activity-regulated cytoskeleton-associated protein
ARHGAP4 Rho GTPase activating protein 4
ARTN artemin
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C19ORF40 chromosome 19 open reading frame 40
C9ORF3 chromosome 9 open reading frame 3
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CD79B CD79b molecule, immunoglobulin-associated beta
CIDEB cell death-inducing DFFA-like effector b
CNR2 cannabinoid receptor 2 (macrophage)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DOC2A double C2-like domains, alpha
DSCAM Down syndrome cell adhesion molecule
DTX2 deltex 2, E3 ubiquitin ligase
EGR3 early growth response 3
EXD3 exonuclease 3'-5' domain containing 3
FJX1 four jointed box 1 (Drosophila)
FKBP5 FK506 binding protein 5
FOXC1 forkhead box C1
GALK1 galactokinase 1
GATA4 GATA binding protein 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC8 homeobox C8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGSF1 immunoglobulin superfamily, member 1
IRX4 iroquois homeobox 4
JMJD4 jumonji domain containing 4
KDM8 lysine (K)-specific demethylase 8
KIAA0125 KIAA0125
KLF13 Kruppel-like factor 13
KLHL21 kelch-like family member 21
KRT31 keratin 31, type I
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
METTL2B methyltransferase like 2B
MPPED2 metallophosphoesterase domain containing 2
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NCS1 neuronal calcium sensor 1
NDRG4 NDRG family member 4
NEUROD1 neuronal differentiation 1
NFE2L3 nuclear factor, erythroid 2-like 3
NPY1R neuropeptide Y receptor Y1
PARP12 poly (ADP-ribose) polymerase family, member 12
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMEL premelanosome protein
POLH polymerase (DNA directed), eta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRE protein tyrosine phosphatase, receptor type, E
PYCRL pyrroline-5-carboxylate reductase-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM41 RNA binding motif protein 41
RHOBTB1 Rho-related BTB domain containing 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
SAA3P serum amyloid A3 pseudogene
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SP1 Sp1 transcription factor
STC2 stanniocalcin 2
STEAP4 STEAP family member 4
STIM1 stromal interaction molecule 1
STRN striatin, calmodulin binding protein
SYCP2 synaptonemal complex protein 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNRC6B trinucleotide repeat containing 6B
TSKU tsukushi, small leucine rich proteoglycan
VGF VGF nerve growth factor inducible
VLDLR very low density lipoprotein receptor
XK X-linked Kx blood group
ZBTB22 zinc finger and BTB domain containing 22
ZFP69B ZFP69 zinc finger protein B
ZNF239 zinc finger protein 239
ZNF573 zinc finger protein 573
ZNF652 zinc finger protein 652