diloxanide-5025 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the diloxanide-5025 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARTN artemin
ATF6B activating transcription factor 6 beta
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAX BCL2-associated X protein
BHLHE40 basic helix-loop-helix family, member e40
C10ORF95 chromosome 10 open reading frame 95
C19ORF66 chromosome 19 open reading frame 66
C19ORF73 chromosome 19 open reading frame 73
C2 complement component 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC71 coiled-coil domain containing 71
CD36 CD36 molecule (thrombospondin receptor)
CLCN6 chloride channel, voltage-sensitive 6
CLTA clathrin, light chain A
CNOT3 CCR4-NOT transcription complex, subunit 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLK2 delta-like 2 homolog (Drosophila)
FKBP10 FK506 binding protein 10, 65 kDa
GK glycerol kinase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HIPK3 homeodomain interacting protein kinase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1L hematological and neurological expressed 1-like
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
ING1 inhibitor of growth family, member 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KIFC1 kinesin family member C1
KRT8 keratin 8, type II
LAMP3 lysosomal-associated membrane protein 3
LIMK1 LIM domain kinase 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMNB1 lamin B1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL16 methyltransferase like 16
MIIP migration and invasion inhibitory protein
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MOCS1 molybdenum cofactor synthesis 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOS1 nitric oxide synthase 1 (neuronal)
NPM3 nucleophosmin/nucleoplasmin 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OGFR opioid growth factor receptor
PBX2 pre-B-cell leukemia homeobox 2
PEX26 peroxisomal biogenesis factor 26
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PML promyelocytic leukemia
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRB1 proline-rich protein BstNI subfamily 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTRF polymerase I and transcript release factor
PVR poliovirus receptor
QPCTL glutaminyl-peptide cyclotransferase-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAPSN receptor-associated protein of the synapse
RB1 retinoblastoma 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A9 solute carrier family 39, member 9
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SP1 Sp1 transcription factor
SP110 SP110 nuclear body protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STK16 serine/threonine kinase 16
SUGP1 SURP and G patch domain containing 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
THBS1 thrombospondin 1
TRIM21 tripartite motif containing 21
TSNAXIP1 translin-associated factor X interacting protein 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UTS2 urotensin 2
WIPI2 WD repeat domain, phosphoinositide interacting 2
YIPF4 Yip1 domain family, member 4
ZBTB40 zinc finger and BTB domain containing 40
ZC3H13 zinc finger CCCH-type containing 13
ZC3H7B zinc finger CCCH-type containing 7B
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
A2M alpha-2-macroglobulin
ACTL8 actin-like 8
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAK1 BCL2-antagonist/killer 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BTF3P11 basic transcription factor 3 pseudogene 11
CAMK4 calcium/calmodulin-dependent protein kinase IV
CES3 carboxylesterase 3
CLDN15 claudin 15
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORO7 coronin 7
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRIP1 cysteine-rich protein 1 (intestinal)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOC2A double C2-like domains, alpha
DYSF dysferlin
ERCC4 excision repair cross-complementation group 4
FBXW12 F-box and WD repeat domain containing 12
FLCN folliculin
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HAUS2 HAUS augmin-like complex, subunit 2
HP1BP3 heterochromatin protein 1, binding protein 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT54 intraflagellar transport 54
IL17RA interleukin 17 receptor A
INO80D INO80 complex subunit D
IPP intracisternal A particle-promoted polypeptide
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0319L KIAA0319-like
KIAA0894 KIAA0894 protein
KLK6 kallikrein-related peptidase 6
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC61 leucine rich repeat containing 61
MFSD11 major facilitator superfamily domain containing 11
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYO1F myosin IF
MYOZ3 myozenin 3
NCALD neurocalcin delta
NFE2L3 nuclear factor, erythroid 2-like 3
NKAIN1 Na+/K+ transporting ATPase interacting 1
NME5 NME/NM23 family member 5
NUP62CL nucleoporin 62kDa C-terminal like
PACS1 phosphofurin acidic cluster sorting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCDHA9 protocadherin alpha 9
PGBD5 piggyBac transposable element derived 5
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRODH proline dehydrogenase (oxidase) 1
PRPH peripherin
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PYCRL pyrroline-5-carboxylate reductase-like
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFWD3 ring finger and WD repeat domain 3
RNF122 ring finger protein 122
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLPI secretory leukocyte peptidase inhibitor
SNTA1 syntrophin, alpha 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STX1A syntaxin 1A (brain)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D19 TBC1 domain family, member 19
TEP1 telomerase-associated protein 1
TEX40 testis expressed 40
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUBA4B tubulin, alpha 4b
UPK3B uroplakin 3B
UPP1 uridine phosphorylase 1
USP19 ubiquitin specific peptidase 19
WDR62 WD repeat domain 62
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34
ZNF442 zinc finger protein 442
ZNF611 zinc finger protein 611
ZNF639 zinc finger protein 639
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816