diloxanide-6679 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the diloxanide-6679 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACE angiotensin I converting enzyme
ACO2 aconitase 2, mitochondrial
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM22 ADAM metallopeptidase domain 22
AHSP alpha hemoglobin stabilizing protein
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ANK2 ankyrin 2, neuronal
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATXN2L ataxin 2-like
AURKC aurora kinase C
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BMP8A bone morphogenetic protein 8a
C17ORF53 chromosome 17 open reading frame 53
C1ORF95 chromosome 1 open reading frame 95
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCL13 chemokine (C-C motif) ligand 13
CLCN1 chloride channel, voltage-sensitive 1
CRISP1 cysteine-rich secretory protein 1
CRISP2 cysteine-rich secretory protein 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXORF21 chromosome X open reading frame 21
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCSTAMP dendrocyte expressed seven transmembrane protein
DENND2A DENN/MADD domain containing 2A
DIAPH2-AS1 DIAPH2 antisense RNA 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMP1 dentin matrix acidic phosphoprotein 1
DRD2 dopamine receptor D2
ELSPBP1 epididymal sperm binding protein 1
FAM129A family with sequence similarity 129, member A
FAM49B family with sequence similarity 49, member B
FLT3LG fms-related tyrosine kinase 3 ligand
FSHB follicle stimulating hormone, beta polypeptide
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GATA3 GATA binding protein 3
GJA8 gap junction protein, alpha 8, 50kDa
GPR85 G protein-coupled receptor 85
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF1B HNF1 homeobox B
IHH indian hedgehog
IKZF4 IKAROS family zinc finger 4 (Eos)
INPP5J inositol polyphosphate-5-phosphatase J
IRF2BP1 interferon regulatory factor 2 binding protein 1
KALRN kalirin, RhoGEF kinase
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCTD14 potassium channel tetramerization domain containing 14
KLHL22 kelch-like family member 22
LINC00115 long intergenic non-protein coding RNA 115
LRP2 low density lipoprotein receptor-related protein 2
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA8 melanoma antigen family A8
MMP25 matrix metallopeptidase 25
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
N4BP2L2 NEDD4 binding protein 2-like 2
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NEK9 NIMA-related kinase 9
NIPAL2 NIPA-like domain containing 2
NIPAL3 NIPA-like domain containing 3
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NUP188 nucleoporin 188kDa
OR7A10 olfactory receptor, family 7, subfamily A, member 10
OR7A5 olfactory receptor, family 7, subfamily A, member 5
OTOR otoraplin
OXCT2 3-oxoacid CoA transferase 2
PAX2 paired box 2
PDZK1 PDZ domain containing 1
PKD2L2 polycystic kidney disease 2-like 2
PPP1R7 protein phosphatase 1, regulatory subunit 7
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RGS7 regulator of G-protein signaling 7
SARM1 sterile alpha and TIR motif containing 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC35E2 solute carrier family 35, member E2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPHK2 sphingosine kinase 2
SPPL2B signal peptide peptidase like 2B
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSX1 synovial sarcoma, X breakpoint 1
SSX3 synovial sarcoma, X breakpoint 3
TACC1 transforming, acidic coiled-coil containing protein 1
TAPBPL TAP binding protein-like
TAS2R1 taste receptor, type 2, member 1
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRIM2 tripartite motif containing 2
TRIM25 tripartite motif containing 25
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
XCL1 chemokine (C motif) ligand 1
YIPF4 Yip1 domain family, member 4
ZNF384 zinc finger protein 384
ZSCAN2 zinc finger and SCAN domain containing 2
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADTRP androgen-dependent TFPI-regulating protein
AFF4 AF4/FMR2 family, member 4
ALPK1 alpha-kinase 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTC betacellulin
C19ORF40 chromosome 19 open reading frame 40
C1ORF21 chromosome 1 open reading frame 21
C7ORF69 chromosome 7 open reading frame 69
CCDC132 coiled-coil domain containing 132
CENPO centromere protein O
CENPQ centromere protein Q
CLCN5 chloride channel, voltage-sensitive 5
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CTSF cathepsin F
DAGLA diacylglycerol lipase, alpha
DMTN dematin actin binding protein
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFNA3 ephrin-A3
FAM46A family with sequence similarity 46, member A
FGF23 fibroblast growth factor 23
FLT4 fms-related tyrosine kinase 4
FRS3 fibroblast growth factor receptor substrate 3
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GRAMD1C GRAM domain containing 1C
HDAC9 histone deacetylase 9
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1E histone cluster 1, H1e
HOOK1 hook microtubule-tethering protein 1
HOXC8 homeobox C8
IPP intracisternal A particle-promoted polypeptide
IQCG IQ motif containing G
ITK IL2-inducible T-cell kinase
JADE1 jade family PHD finger 1
KLK7 kallikrein-related peptidase 7
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LY96 lymphocyte antigen 96
MEIS1 Meis homeobox 1
METTL8 methyltransferase like 8
NARFL nuclear prelamin A recognition factor-like
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NKX3-2 NK3 homeobox 2
NOL10 nucleolar protein 10
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPR3 natriuretic peptide receptor 3
NYNRIN NYN domain and retroviral integrase containing
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACS1 phosphofurin acidic cluster sorting protein 1
PAX6 paired box 6
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PROL1 proline rich, lacrimal 1
PTK6 protein tyrosine kinase 6
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB40A RAB40A, member RAS oncogene family
RAD51B RAD51 paralog B
SCEL sciellin
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SENP7 SUMO1/sentrin specific peptidase 7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC12A9 solute carrier family 12, member 9
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SRD5A3 steroid 5 alpha-reductase 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYNGR3 synaptogyrin 3
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TESPA1 thymocyte expressed, positive selection associated 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBS3 thrombospondin 3
TMEM180 transmembrane protein 180
TNNI3 troponin I type 3 (cardiac)
TRAPPC13 trafficking protein particle complex 13
TRDMT1 tRNA aspartic acid methyltransferase 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TTLL1 tubulin tyrosine ligase-like family member 1
TXK TXK tyrosine kinase
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
YY2 YY2 transcription factor
ZBTB6 zinc finger and BTB domain containing 6
ZC2HC1C zinc finger, C2HC-type containing 1C
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF141 zinc finger protein 141
ZNF197 zinc finger protein 197
ZNF264 zinc finger protein 264
ZNF276 zinc finger protein 276
ZNF286A zinc finger protein 286A
ZNF391 zinc finger protein 391