diltiazem-5309 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the diltiazem-5309 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADGRE5 adhesion G protein-coupled receptor E5
AFAP1 actin filament associated protein 1
AKAP17A A kinase (PRKA) anchor protein 17A
ALCAM activated leukocyte cell adhesion molecule
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP11A ATPase, class VI, type 11A
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL9 B-cell CLL/lymphoma 9
BTF3P11 basic transcription factor 3 pseudogene 11
BTN2A2 butyrophilin, subfamily 2, member A2
C19ORF60 chromosome 19 open reading frame 60
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CDHR1 cadherin-related family member 1
CDK19 cyclin-dependent kinase 19
CENPO centromere protein O
CEP162 centrosomal protein 162kDa
CIC capicua transcriptional repressor
CLCN7 chloride channel, voltage-sensitive 7
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTNA dystrobrevin, alpha
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
FAM189A2 family with sequence similarity 189, member A2
FBXO22 F-box protein 22
FBXO9 F-box protein 9
FER fer (fps/fes related) tyrosine kinase
FNDC3A fibronectin type III domain containing 3A
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA4 GATA binding protein 4
GRM1 glutamate receptor, metabotropic 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDLBP high density lipoprotein binding protein
HLA-B major histocompatibility complex, class I, B
HNMT histamine N-methyltransferase
ING4 inhibitor of growth family, member 4
IRF4 interferon regulatory factor 4
KIF1C kinesin family member 1C
KRIT1 KRIT1, ankyrin repeat containing
LRRC20 leucine rich repeat containing 20
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYST lysosomal trafficking regulator
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP4 microtubule-associated protein 4
MAST3 microtubule associated serine/threonine kinase 3
MFN2 mitofusin 2
MIEF1 mitochondrial elongation factor 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRGN neurogranin (protein kinase C substrate, RC3)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSTF1 osteoclast stimulating factor 1
PACS1 phosphofurin acidic cluster sorting protein 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCNX pecanex homolog (Drosophila)
PDAP1 PDGFA associated protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PLA2G3 phospholipase A2, group III
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP5C protein phosphatase 5, catalytic subunit
PRDX2 peroxiredoxin 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRR4 proline rich 4 (lacrimal)
RAB3A RAB3A, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RGS10 regulator of G-protein signaling 10
RNF19B ring finger protein 19B
RNF2 ring finger protein 2
RNF6 ring finger protein (C3H2C3 type) 6
ROM1 retinal outer segment membrane protein 1
S100A4 S100 calcium binding protein A4
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SOX12 SRY (sex determining region Y)-box 12
STK38L serine/threonine kinase 38 like
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TDRKH tudor and KH domain containing
TFE3 transcription factor binding to IGHM enhancer 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TLDC1 TBC/LysM-associated domain containing 1
TMEM259 transmembrane protein 259
TNS2 tensin 2
TPMT thiopurine S-methyltransferase
TREX1 three prime repair exonuclease 1
TTC30A tetratricopeptide repeat domain 30A
UBE3A ubiquitin protein ligase E3A
USP34 ubiquitin specific peptidase 34
VAX2 ventral anterior homeobox 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF24 zinc finger protein 24
ZNF304 zinc finger protein 304
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACADSB acyl-CoA dehydrogenase, short/branched chain
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD10 ankyrin repeat domain 10
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
AXIN1 axin 1
BRD9 bromodomain containing 9
C17ORF85 chromosome 17 open reading frame 85
C1ORF106 chromosome 1 open reading frame 106
CCDC25 coiled-coil domain containing 25
CCDC6 coiled-coil domain containing 6
CCDC94 coiled-coil domain containing 94
CHPF chondroitin polymerizing factor
CLSPN claspin
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL9A2 collagen, type IX, alpha 2
CTSV cathepsin V
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DUSP5 dual specificity phosphatase 5
EGLN2 egl-9 family hypoxia-inducible factor 2
EVPL envoplakin
FCHSD2 FCH and double SH3 domains 2
FGGY FGGY carbohydrate kinase domain containing
FOXC1 forkhead box C1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAA glucosidase, alpha; acid
GAB2 GRB2-associated binding protein 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRAMD4 GRAM domain containing 4
HAUS7 HAUS augmin-like complex, subunit 7
HIRIP3 HIRA interacting protein 3
HTT huntingtin
ILK integrin-linked kinase
KCNK15 potassium channel, two pore domain subfamily K, member 15
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LINC00115 long intergenic non-protein coding RNA 115
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED15 mediator complex subunit 15
MEIS1 Meis homeobox 1
MITF microphthalmia-associated transcription factor
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
MYO9A myosin IXA
NME3 NME/NM23 nucleoside diphosphate kinase 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMZP3 POM121 and ZP3 fusion
PP14571 uncharacterized LOC100130449
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTCD2 pentatricopeptide repeat domain 2
PTK6 protein tyrosine kinase 6
RFTN1 raftlin, lipid raft linker 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF113A ring finger protein 113A
RNF31 ring finger protein 31
SHPK sedoheptulokinase
SIK1 salt-inducible kinase 1
SNHG3 small nucleolar RNA host gene 3
SNIP1 Smad nuclear interacting protein 1
SPHK1 sphingosine kinase 1
SRSF4 serine/arginine-rich splicing factor 4
STARD13 StAR-related lipid transfer (START) domain containing 13
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TDRD1 tudor domain containing 1
TMEM104 transmembrane protein 104
TMEM39B transmembrane protein 39B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPST1 tyrosylprotein sulfotransferase 1
TWSG1 twisted gastrulation BMP signaling modulator 1
USP21 ubiquitin specific peptidase 21
WWC2 WW and C2 domain containing 2
XAB2 XPA binding protein 2
ZC3H12A zinc finger CCCH-type containing 12A
ZNF106 zinc finger protein 106
ZNF282 zinc finger protein 282
ZNF331 zinc finger protein 331
ZNF557 zinc finger protein 557
ZNF586 zinc finger protein 586
ZNF692 zinc finger protein 692
ZNF7 zinc finger protein 7
ZNF8 zinc finger protein 8
ZNF862 zinc finger protein 862
ZNHIT2 zinc finger, HIT-type containing 2