dimenhydrinate Gene Set

Dataset	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category	transcriptomics
Type	small molecule perturbation
Description	The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention and treatment of motion sickness. (Chemical Entities of Biological Interest Ontology, CHEBI_4604)
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Genes

19 genes differentially expressed following the dimenhydrinate small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol	Name	Standardized Value
TOMM34	translocase of outer mitochondrial membrane 34	4.92595
KLHDC2	kelch domain containing 2	4.19164
SLC5A6	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	3.95309
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	3.53585
PRPH	peripherin	3.27824
LINC00574	long intergenic non-protein coding RNA 574	3.25807
KIF3C	kinesin family member 3C	3.23125
ZNF318	zinc finger protein 318	3.15018
EPB41L4B	erythrocyte membrane protein band 4.1 like 4B	3.08647
CRK	v-crk avian sarcoma virus CT10 oncogene homolog	3.06469
TAGLN3	transgelin 3	3.0345
TUBB4B	tubulin, beta 4B class IVb	3.01278

decreased expression

Symbol	Name	Standardized Value
ZMYM2	zinc finger, MYM-type 2	-4.00694
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	-3.34352
TSPAN4	tetraspanin 4	-3.17371
TFF2	trefoil factor 2	-3.06277
CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit	-3.02062
MAP7	microtubule-associated protein 7	-3.01721
TRMT44	tRNA methyltransferase 44 homolog (S. cerevisiae)	-3.00061