dimethadione-3029 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dimethadione-3029 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAM12 ADAM metallopeptidase domain 12
AIM1L absent in melanoma 1-like
AKR1C1 aldo-keto reductase family 1, member C1
AMACR alpha-methylacyl-CoA racemase
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AREG amphiregulin
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATP10A ATPase, class V, type 10A
ATP9A ATPase, class II, type 9A
BGN biglycan
C19ORF73 chromosome 19 open reading frame 73
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD22 CD22 molecule
CEMP1 cementum protein 1
CEP170B centrosomal protein 170B
CLCA2 chloride channel accessory 2
CLDN3 claudin 3
CLSTN2 calsyntenin 2
COL10A1 collagen, type X, alpha 1
CXXC4 CXXC finger protein 4
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DDO D-aspartate oxidase
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DRD1 dopamine receptor D1
DST dystonin
DUSP1 dual specificity phosphatase 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ELAC2 elaC ribonuclease Z 2
F5 coagulation factor V (proaccelerin, labile factor)
FAM153A family with sequence similarity 153, member A
FETUB fetuin B
FHL1 four and a half LIM domains 1
FKBP6 FK506 binding protein 6, 36kDa
FOSL2 FOS-like antigen 2
FXYD2 FXYD domain containing ion transport regulator 2
GCGR glucagon receptor
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
IDS iduronate 2-sulfatase
IGHD immunoglobulin heavy constant delta
IGKV3-20 immunoglobulin kappa variable 3-20
IL11 interleukin 11
INADL InaD-like (Drosophila)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JPH3 junctophilin 3
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNK12 potassium channel, two pore domain subfamily K, member 12
KLHL35 kelch-like family member 35
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMOD1 leiomodin 1 (smooth muscle)
LRP1 low density lipoprotein receptor-related protein 1
MAPK7 mitogen-activated protein kinase 7
MCF2 MCF.2 cell line derived transforming sequence
MCHR1 melanin-concentrating hormone receptor 1
MECOM MDS1 and EVI1 complex locus
MNMIP1 manchette microtubule inner protein 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MSX2 msh homeobox 2
NES nestin
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NMUR1 neuromedin U receptor 1
NPR1 natriuretic peptide receptor 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OLFM1 olfactomedin 1
PLEK2 pleckstrin 2
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDM9 PR domain containing 9
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RBBP4 retinoblastoma binding protein 4
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIMS2 regulating synaptic membrane exocytosis 2
SARM1 sterile alpha and TIR motif containing 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SRPX2 sushi-repeat containing protein, X-linked 2
STX11 syntaxin 11
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TECTA tectorin alpha
TF transferrin
TJP1 tight junction protein 1
TMEM140 transmembrane protein 140
TMEM180 transmembrane protein 180
TMOD1 tropomodulin 1
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNP1 transition protein 1 (during histone to protamine replacement)
USP2 ubiquitin specific peptidase 2
VIP vasoactive intestinal peptide
ZFHX3 zinc finger homeobox 3
ZNF276 zinc finger protein 276

decreased expression

Symbol Name
ACO1 aconitase 1, soluble
ACPP acid phosphatase, prostate
ADGB androglobin
ADTRP androgen-dependent TFPI-regulating protein
AIM2 absent in melanoma 2
ARMCX4 armadillo repeat containing, X-linked 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCAR3 breast cancer anti-estrogen resistance 3
BPHL biphenyl hydrolase-like (serine hydrolase)
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C8A complement component 8, alpha polypeptide
CCNT1 cyclin T1
CDHR2 cadherin-related family member 2
CHM choroideremia (Rab escort protein 1)
CHMP6 charged multivesicular body protein 6
CHPF chondroitin polymerizing factor
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CROT carnitine O-octanoyltransferase
CTAGE9 CTAGE family, member 9
DUSP2 dual specificity phosphatase 2
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EXD3 exonuclease 3'-5' domain containing 3
FBXO46 F-box protein 46
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FHL3 four and a half LIM domains 3
GBP2 guanylate binding protein 2, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GEMIN8 gem (nuclear organelle) associated protein 8
GID4 GID complex subunit 4
GJA1 gap junction protein, alpha 1, 43kDa
GLCE glucuronic acid epimerase
HHLA3 HERV-H LTR-associating 3
HIST1H1B histone cluster 1, H1b
HOXB9 homeobox B9
HSPB6 heat shock protein, alpha-crystallin-related, B6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA1107 KIAA1107
KIF13B kinesin family member 13B
KPTN kaptin (actin binding protein)
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBIP MAP3K12 binding inhibitory protein 1
MLPH melanophilin
MON1B MON1 secretory trafficking family member B
MTMR6 myotubularin related protein 6
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NABP1 nucleic acid binding protein 1
NABP2 nucleic acid binding protein 2
NINJ2 ninjurin 2
NTSR1 neurotensin receptor 1 (high affinity)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OXCT2 3-oxoacid CoA transferase 2
PGPEP1 pyroglutamyl-peptidase I
PIR pirin (iron-binding nuclear protein)
PLA2G15 phospholipase A2, group XV
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121 POM121 transmembrane nucleoporin
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS21 protease, serine, 21 (testisin)
QSER1 glutamine and serine rich 1
RAB3D RAB3D, member RAS oncogene family
RARS arginyl-tRNA synthetase
RASAL2 RAS protein activator like 2
RGS13 regulator of G-protein signaling 13
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL23AP53 ribosomal protein L23a pseudogene 53
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGMS1 sphingomyelin synthase 1
SIX3 SIX homeobox 3
SKA1 spindle and kinetochore associated complex subunit 1
SLC17A2 solute carrier family 17, member 2
SLC35F6 solute carrier family 35, member F6
SLC38A6 solute carrier family 38, member 6
SPAG4 sperm associated antigen 4
SPATA2L spermatogenesis associated 2-like
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STRN striatin, calmodulin binding protein
TLR1 toll-like receptor 1
TMEM242 transmembrane protein 242
TNS2 tensin 2
TRAPPC13 trafficking protein particle complex 13
TRPS1 trichorhinophalangeal syndrome I
TUFT1 tuftelin 1
VANGL1 VANGL planar cell polarity protein 1
WASF3 WAS protein family, member 3
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF225 zinc finger protein 225
ZNF552 zinc finger protein 552
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747
ZXDB zinc finger, X-linked, duplicated B