dimethadione-4607 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the dimethadione-4607 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ANKRD6 ankyrin repeat domain 6
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ATAT1 alpha tubulin acetyltransferase 1
ATP10B ATPase, class V, type 10B
C10ORF12 chromosome 10 open reading frame 12
C1ORF54 chromosome 1 open reading frame 54
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C21ORF2 chromosome 21 open reading frame 2
C5ORF42 chromosome 5 open reading frame 42
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CADM3 cell adhesion molecule 3
CARTPT CART prepropeptide
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
COBL cordon-bleu WH2 repeat protein
CPN2 carboxypeptidase N, polypeptide 2
CSF1 colony stimulating factor 1 (macrophage)
CTSG cathepsin G
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGKE diacylglycerol kinase, epsilon 64kDa
DLX5 distal-less homeobox 5
DNASE1L3 deoxyribonuclease I-like 3
DZIP1 DAZ interacting zinc finger protein 1
EGFL7 EGF-like-domain, multiple 7
EPYC epiphycan
ESR1 estrogen receptor 1
FABP3 fatty acid binding protein 3, muscle and heart
FAM149A family with sequence similarity 149, member A
FLT4 fms-related tyrosine kinase 4
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GFI1 growth factor independent 1 transcription repressor
GJA4 gap junction protein, alpha 4, 37kDa
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GYPA glycophorin A (MNS blood group)
HCRTR1 hypocretin (orexin) receptor 1
HEG1 heart development protein with EGF-like domains 1
HES2 hes family bHLH transcription factor 2
HOXC4 homeobox C4
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IDI2-AS1 IDI2 antisense RNA 1
IGLJ3 immunoglobulin lambda joining 3
IL6ST interleukin 6 signal transducer
KIF17 kinesin family member 17
KRT12 keratin 12, type I
KSR1 kinase suppressor of ras 1
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LST1 leukocyte specific transcript 1
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MNMIP1 manchette microtubule inner protein 1
MRAS muscle RAS oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NME8 NME/NM23 family member 8
OSGIN2 oxidative stress induced growth inhibitor family member 2
PADI4 peptidyl arginine deiminase, type IV
PAX2 paired box 2
PDE10A phosphodiesterase 10A
PLA2G2E phospholipase A2, group IIE
PRKG2 protein kinase, cGMP-dependent, type II
PRR5L proline rich 5 like
PTH1R parathyroid hormone 1 receptor
RAG2 recombination activating gene 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCE1 Ras converting CAAX endopeptidase 1
RIC3 RIC3 acetylcholine receptor chaperone
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
S100A13 S100 calcium binding protein A13
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMG2 semenogelin II
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SEPP1 selenoprotein P, plasma, 1
SH2B1 SH2B adaptor protein 1
SIDT2 SID1 transmembrane family, member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNRK SNF related kinase
SPRR1A small proline-rich protein 1A
SPRYD7 SPRY domain containing 7
STRA6 stimulated by retinoic acid 6
TACR2 tachykinin receptor 2
TMOD1 tropomodulin 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TONSL tonsoku-like, DNA repair protein
TRIM15 tripartite motif containing 15
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCAN versican
WNT8B wingless-type MMTV integration site family, member 8B
ZIC3 Zic family member 3
ZNF214 zinc finger protein 214

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD17B abhydrolase domain containing 17B
ADAT1 adenosine deaminase, tRNA-specific 1
AFAP1 actin filament associated protein 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA2P1 annexin A2 pseudogene 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF30 chromosome 11 open reading frame 30
CA9 carbonic anhydrase IX
CDADC1 cytidine and dCMP deaminase domain containing 1
CHMP6 charged multivesicular body protein 6
CISH cytokine inducible SH2-containing protein
CLCN5 chloride channel, voltage-sensitive 5
CLDN4 claudin 4
DEAF1 DEAF1 transcription factor
DHRS11 dehydrogenase/reductase (SDR family) member 11
DTX2 deltex 2, E3 ubiquitin ligase
ETNK2 ethanolamine kinase 2
FADS2 fatty acid desaturase 2
FAM131B family with sequence similarity 131, member B
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALK1 galactokinase 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR176 G protein-coupled receptor 176
GTPBP2 GTP binding protein 2
HAMP hepcidin antimicrobial peptide
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
IL7 interleukin 7
IQSEC2 IQ motif and Sec7 domain 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0556 KIAA0556
KLF3 Kruppel-like factor 3 (basic)
LINC00597 long intergenic non-protein coding RNA 597
LRP5L low density lipoprotein receptor-related protein 5-like
MB myoglobin
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFSD12 major facilitator superfamily domain containing 12
MVP major vault protein
MYLIP myosin regulatory light chain interacting protein
NDE1 nudE neurodevelopment protein 1
NDRG4 NDRG family member 4
NEUROD1 neuronal differentiation 1
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NRSN2 neurensin 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSMR oncostatin M receptor
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALMD palmdelphin
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PLCD1 phospholipase C, delta 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRAME preferentially expressed antigen in melanoma
PREP prolyl endopeptidase
PRSS53 protease, serine, 53
PTK7 protein tyrosine kinase 7 (inactive)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RIMBP2 RIMS binding protein 2
RNF31 ring finger protein 31
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAYSD1 SAYSVFN motif domain containing 1
SFRP5 secreted frizzled-related protein 5
SH3GLB2 SH3-domain GRB2-like endophilin B2
SHROOM2 shroom family member 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG9 SMG9 nonsense mediated mRNA decay factor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPIDR scaffolding protein involved in DNA repair
STBD1 starch binding domain 1
STIM1 stromal interaction molecule 1
STIP1 stress-induced phosphoprotein 1
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TEAD3 TEA domain family member 3
THBS3 thrombospondin 3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM242 transmembrane protein 242
TOR4A torsin family 4, member A
UROS uroporphyrinogen III synthase
USP21 ubiquitin specific peptidase 21
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
YY2 YY2 transcription factor
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227