diminished Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

397 genes co-occuring with the biological term diminished in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMH anti-Mullerian hormone
AMPD1 adenosine monophosphate deaminase 1
ANGPT2 angiopoietin 2
ANKK1 ankyrin repeat and kinase domain containing 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLN apelin
APLNR apelin receptor
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARG1 arginase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATOH1 atonal homolog 1 (Drosophila)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AURKA aurora kinase A
AVP arginine vasopressin
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
BACE1 beta-site APP-cleaving enzyme 1
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BMP7 bone morphogenetic protein 7
BPI bactericidal/permeability-increasing protein
CA9 carbonic anhydrase IX
CAV1 caveolin 1, caveolae protein, 22kDa
CCAR1 cell division cycle and apoptosis regulator 1
CCND1 cyclin D1
CD200 CD200 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD6 CD6 molecule
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDKL5 cyclin-dependent kinase-like 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CFHR1 complement factor H-related 1
CFHR3 complement factor H-related 3
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHGA chromogranin A
CHUK conserved helix-loop-helix ubiquitous kinase
CLN9 ceroid-lipofuscinosis, neuronal 9
CLTC clathrin, heavy chain (Hc)
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP2 contactin associated protein-like 2
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
COMT catechol-O-methyltransferase
CP ceruloplasmin (ferroxidase)
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CSF1R colony stimulating factor 1 receptor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTSC cathepsin C
CTSZ cathepsin Z
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCX doublecortin
DEFB4A defensin, beta 4A
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DYNLL1 dynein, light chain, LC8-type 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPB41 erythrocyte membrane protein band 4.1
ERCC1 excision repair cross-complementation group 1
ERCC6 excision repair cross-complementation group 6
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FECH ferrochelatase
FGF23 fibroblast growth factor 23
FGG fibrinogen gamma chain
FH fumarate hydratase
FLG filaggrin
FMR1 fragile X mental retardation 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
FUCA1 fucosidase, alpha-L- 1, tissue
FUS FUS RNA binding protein
FXN frataxin
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF9 growth differentiation factor 9
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GIP gastric inhibitory polypeptide
GJA1 gap junction protein, alpha 1, 43kDa
GJB2 gap junction protein, beta 2, 26kDa
GLB1 galactosidase, beta 1
GLTP glycolipid transfer protein
GNRHR gonadotropin-releasing hormone receptor
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HABP2 hyaluronan binding protein 2
HADH hydroxyacyl-CoA dehydrogenase
HAMP hepcidin antimicrobial peptide
HCRT hypocretin (orexin) neuropeptide precursor
HDAC1 histone deacetylase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST4H4 histone cluster 4, H4
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA13 homeobox A13
HPCA hippocalcin
HRAS Harvey rat sarcoma viral oncogene homolog
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
ICK intestinal cell (MAK-like) kinase
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL33 interleukin 33
IL4 interleukin 4
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
INHBB inhibin, beta B
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK1 interleukin-1 receptor-associated kinase 1
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KHK ketohexokinase (fructokinase)
KIAA1524 KIAA1524
KIF5B kinesin family member 5B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KLK7 kallikrein-related peptidase 7
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT15 keratin 15, type I
KRT18 keratin 18, type I
LAMP2 lysosomal-associated membrane protein 2
LDHA lactate dehydrogenase A
LEP leptin
LIPG lipase, endothelial
LRP6 low density lipoprotein receptor-related protein 6
LRRK2 leucine-rich repeat kinase 2
LTB4R2 leukotriene B4 receptor 2
LTBP1 latent transforming growth factor beta binding protein 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR125B1 microRNA 125b-1
MIR126 microRNA 126
MIR155 microRNA 155
MIR198 microRNA 198
MIR224 microRNA 224
MIR326 microRNA 326
MIR506 microRNA 506
MLH1 mutL homolog 1
MLYCD malonyl-CoA decarboxylase
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MUC17 mucin 17, cell surface associated
MYBPC3 myosin binding protein C, cardiac
MYD88 myeloid differentiation primary response 88
MYO6 myosin VI
NABP2 nucleic acid binding protein 2
NCS1 neuronal calcium sensor 1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NEK9 NIMA-related kinase 9
NEU1 sialidase 1 (lysosomal sialidase)
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NOD2 nucleotide-binding oligomerization domain containing 2
NODAL nodal growth differentiation factor
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUAK1 NUAK family, SNF1-like kinase, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEPD peptidase D
PGR progesterone receptor
PGRMC1 progesterone receptor membrane component 1
PI3 peptidase inhibitor 3, skin-derived
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLN phospholamban
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
PPARA peroxisome proliferator-activated receptor alpha
PRELP proline/arginine-rich end leucine-rich repeat protein
PRL prolactin
PRMT1 protein arginine methyltransferase 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTEN phosphatase and tensin homolog
PTGES prostaglandin E synthase
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYY peptide YY
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1A RAP1A, member of RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARA retinoic acid receptor, alpha
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBM8A RNA binding motif protein 8A
REG3A regenerating islet-derived 3 alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOC ras homolog family member C
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RXRB retinoid X receptor, beta
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
SACK1B scaffolding CK1 anchoring protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SELE selectin E
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC45A2 solute carrier family 45, member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SLURP1 secreted LY6/PLAUR domain containing 1
SMAD7 SMAD family member 7
SMYD3 SET and MYND domain containing 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS3 suppressor of cytokine signaling 3
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SULF1 sulfatase 1
SULF2 sulfatase 2
SUV420H2 suppressor of variegation 4-20 homolog 2 (Drosophila)
SYTL1 synaptotagmin-like 1
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THBD thrombomodulin
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TJP1 tight junction protein 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TPT1 tumor protein, translationally-controlled 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TSC22D3 TSC22 domain family, member 3
TTR transthyretin
TUBA1A tubulin, alpha 1a
UBA1 ubiquitin-like modifier activating enzyme 1
UBA6 ubiquitin-like modifier activating enzyme 6
UBE4B ubiquitination factor E4B
UBQLN1 ubiquilin 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
VTN vitronectin
VWF von Willebrand factor
WNT7A wingless-type MMTV integration site family, member 7A
WWOX WW domain containing oxidoreductase
XDH xanthine dehydrogenase
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)