dinoprostone-6586 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the dinoprostone-6586 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANGPTL4 angiopoietin-like 4
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
AQP3 aquaporin 3 (Gill blood group)
ARL14 ADP-ribosylation factor-like 14
BCR breakpoint cluster region
BTBD7 BTB (POZ) domain containing 7
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH7 cadherin 7, type 2
CLN3 ceroid-lipofuscinosis, neuronal 3
COPE coatomer protein complex, subunit epsilon
COX4I1 cytochrome c oxidase subunit IV isoform 1
CREM cAMP responsive element modulator
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CTNS cystinosin, lysosomal cystine transporter
CXCL3 chemokine (C-X-C motif) ligand 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMBT1 deleted in malignant brain tumors 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENO1 enolase 1, (alpha)
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOC7 exocyst complex component 7
FABP4 fatty acid binding protein 4, adipocyte
FAM127B family with sequence similarity 127, member B
FHL1 four and a half LIM domains 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSBP3 glucuronidase, beta pseudogene 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL15RA interleukin 15 receptor, alpha
IL33R interleukin 33 receptor
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JUP junction plakoglobin
KIAA0930 KIAA0930
LRP6 low density lipoprotein receptor-related protein 6
LYPD3 LY6/PLAUR domain containing 3
MDC1 mediator of DNA-damage checkpoint 1
NCK1 NCK adaptor protein 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDS5A PDS5 cohesin associated factor A
PGAP2 post-GPI attachment to proteins 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLCD1 phospholipase C, delta 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLIN2 perilipin 2
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POM121 POM121 transmembrane nucleoporin
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRR3 proline rich 3
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK6 protein tyrosine kinase 6
RAB29 RAB29, member RAS oncogene family
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF126 ring finger protein 126
RNFT1 ring finger protein, transmembrane 1
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SGSM2 small G protein signaling modulator 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SKI SKI proto-oncogene
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35E1 solute carrier family 35, member E1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SMOX spermine oxidase
SPATS2L spermatogenesis associated, serine-rich 2-like
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBL1X transducin (beta)-like 1X-linked
TGFB2 transforming growth factor, beta 2
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM66 tripartite motif containing 66
TSKU tsukushi, small leucine rich proteoglycan
TUBGCP5 tubulin, gamma complex associated protein 5
USF2 upstream transcription factor 2, c-fos interacting
ZC3H7B zinc finger CCCH-type containing 7B
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRB2 adhesion G protein-coupled receptor B2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALS2CL ALS2 C-terminal like
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
ATF7IP2 activating transcription factor 7 interacting protein 2
BAG3 BCL2-associated athanogene 3
BICC1 BicC family RNA binding protein 1
C3 complement component 3
CAPN5 calpain 5
CCDC25 coiled-coil domain containing 25
CCDC94 coiled-coil domain containing 94
CCP110 centriolar coiled coil protein 110kDa
CDK18 cyclin-dependent kinase 18
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP112 centrosomal protein 112kDa
CNTD2 cyclin N-terminal domain containing 2
CNTN1 contactin 1
CORO1A coronin, actin binding protein, 1A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CST4 cystatin S
CTGF connective tissue growth factor
CTNNBIP1 catenin, beta interacting protein 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND2D DENN/MADD domain containing 2D
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
FAM188A family with sequence similarity 188, member A
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HCG4 HLA complex group 4 (non-protein coding)
HIRIP3 HIRA interacting protein 3
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HIST3H2A histone cluster 3, H2a
HOXC5 homeobox C5
HSPA2 heat shock 70kDa protein 2
IQCA1 IQ motif containing with AAA domain 1
KLHL29 kelch-like family member 29
KRT75 keratin 75, type II
KRT9 keratin 9, type I
LYPLA2P1 lysophospholipase II pseudogene 1
MCTP1 multiple C2 domains, transmembrane 1
MMP13 matrix metallopeptidase 13
NAV2 neuron navigator 2
NDNF neuron-derived neurotrophic factor
NIPAL2 NIPA-like domain containing 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NPY1R neuropeptide Y receptor Y1
NUP62CL nucleoporin 62kDa C-terminal like
NXPH4 neurexophilin 4
OGFRL1 opioid growth factor receptor-like 1
ONECUT2 one cut homeobox 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PBLD phenazine biosynthesis-like protein domain containing
PER3 period circadian clock 3
PEX26 peroxisomal biogenesis factor 26
PLCH2 phospholipase C, eta 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PNPO pyridoxamine 5'-phosphate oxidase
POMT1 protein-O-mannosyltransferase 1
PRICKLE3 prickle homolog 3 (Drosophila)
PROL1 proline rich, lacrimal 1
PRPH peripherin
PRR14L proline rich 14-like
PRR16 proline rich 16
PTX3 pentraxin 3, long
RNF126P1 ring finger protein 126 pseudogene 1
ROM1 retinal outer segment membrane protein 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS4Y1 ribosomal protein S4, Y-linked 1
RUSC2 RUN and SH3 domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCN9A sodium channel, voltage gated, type IX alpha subunit
SEC14L2 SEC14-like 2 (S. cerevisiae)
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHROOM2 shroom family member 2
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC12A8 solute carrier family 12, member 8
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPAG16 sperm associated antigen 16
SPATA2L spermatogenesis associated 2-like
TAGLN3 transgelin 3
TMEM104 transmembrane protein 104
TTLL7 tubulin tyrosine ligase-like family member 7
TTN titin
USP19 ubiquitin specific peptidase 19
WDR62 WD repeat domain 62
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF324 zinc finger protein 324
ZNF415 zinc finger protein 415
ZNF552 zinc finger protein 552
ZNF639 zinc finger protein 639