diphenhydramine-1830 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the diphenhydramine-1830 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABR active BCR-related
ACYP1 acylphosphatase 1, erythrocyte (common) type
ACYP2 acylphosphatase 2, muscle type
AGFG2 ArfGAP with FG repeats 2
ASPH aspartate beta-hydroxylase
ATXN1 ataxin 1
AXIN1 axin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2L2 BCL2-like 2
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRIX1 BRX1, biogenesis of ribosomes
C2ORF68 chromosome 2 open reading frame 68
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAPN2 calpain 2, (m/II) large subunit
CCDC88A coiled-coil domain containing 88A
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCP110 centriolar coiled coil protein 110kDa
CD47 CD47 molecule
CDC37L1 cell division cycle 37-like 1
CDC5L cell division cycle 5-like
CDYL chromodomain protein, Y-like
CIRBP cold inducible RNA binding protein
CTBS chitobiase, di-N-acetyl-
CTH cystathionine gamma-lyase
CUL7 cullin 7
DAZAP2 DAZ associated protein 2
DBT dihydrolipoamide branched chain transacylase E2
DLX2 distal-less homeobox 2
DTX2 deltex 2, E3 ubiquitin ligase
FAM179B family with sequence similarity 179, member B
FANCF Fanconi anemia, complementation group F
FHL1 four and a half LIM domains 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GLG1 golgi glycoprotein 1
GPR137 G protein-coupled receptor 137
GPR17 G protein-coupled receptor 17
GUSBP3 glucuronidase, beta pseudogene 3
HNMT histamine N-methyltransferase
HP1BP3 heterochromatin protein 1, binding protein 3
IFI16 interferon, gamma-inducible protein 16
INPP5K inositol polyphosphate-5-phosphatase K
INSIG1 insulin induced gene 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCTD7 potassium channel tetramerization domain containing 7
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDM6A lysine (K)-specific demethylase 6A
KLK10 kallikrein-related peptidase 10
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LMAN1 lectin, mannose-binding, 1
LOC644450 uncharacterized LOC644450
LPIN2 lipin 2
MATN3 matrilin 3
MBNL1 muscleblind-like splicing regulator 1
MED6 mediator complex subunit 6
MFN1 mitofusin 1
MT1F metallothionein 1F
MTAP methylthioadenosine phosphorylase
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NCOA3 nuclear receptor coactivator 3
NFYA nuclear transcription factor Y, alpha
NNT nicotinamide nucleotide transhydrogenase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRR protein tyrosine phosphatase, receptor type, R
RAD52 RAD52 homolog (S. cerevisiae)
RBL2 retinoblastoma-like 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SOCS6 suppressor of cytokine signaling 6
SS18 synovial sarcoma translocation, chromosome 18
TADA2A transcriptional adaptor 2A
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TREX1 three prime repair exonuclease 1
TRIO trio Rho guanine nucleotide exchange factor
TTF2 transcription termination factor, RNA polymerase II
TUBA3C tubulin, alpha 3c
ULK1 unc-51 like autophagy activating kinase 1
UTRN utrophin
VAMP4 vesicle-associated membrane protein 4
WDR1 WD repeat domain 1
WWC2 WW and C2 domain containing 2
ZFYVE16 zinc finger, FYVE domain containing 16
ZFYVE9 zinc finger, FYVE domain containing 9
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF358 zinc finger protein 358
ZNF551 zinc finger protein 551
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C16ORF59 chromosome 16 open reading frame 59
CADPS2 Ca++-dependent secretion activator 2
CCNJ cyclin J
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIDEC cell death-inducing DFFA-like effector c
COG7 component of oligomeric golgi complex 7
COQ4 coenzyme Q4
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTSF cathepsin F
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DLL3 delta-like 3 (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DNMBP dynamin binding protein
EFCAB2 EF-hand calcium binding domain 2
EFNB1 ephrin-B1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM214B family with sequence similarity 214, member B
FAM53B family with sequence similarity 53, member B
FANCE Fanconi anemia, complementation group E
GAL3ST4 galactose-3-O-sulfotransferase 4
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
GPR1 G protein-coupled receptor 1
GPX2 glutathione peroxidase 2
HDAC7 histone deacetylase 7
HIST1H3B histone cluster 1, H3b
HLX H2.0-like homeobox
HOXA1 homeobox A1
HYAL3 hyaluronoglucosaminidase 3
IGFLR1 IGF-like family receptor 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INF2 inverted formin, FH2 and WH2 domain containing
INPPL1 inositol polyphosphate phosphatase-like 1
KDM5C lysine (K)-specific demethylase 5C
KIFC3 kinesin family member C3
KIRREL kin of IRRE like (Drosophila)
LIMS2 LIM and senescent cell antigen-like domains 2
LPAR6 lysophosphatidic acid receptor 6
LYPD1 LY6/PLAUR domain containing 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAN2B2 mannosidase, alpha, class 2B, member 2
MAP6D1 MAP6 domain containing 1
MON1B MON1 secretory trafficking family member B
MRPL17 mitochondrial ribosomal protein L17
MYLIP myosin regulatory light chain interacting protein
NPR3 natriuretic peptide receptor 3
PAQR4 progestin and adipoQ receptor family member IV
PAQR6 progestin and adipoQ receptor family member VI
PARP3 poly (ADP-ribose) polymerase family, member 3
PCBP4 poly(rC) binding protein 4
PDGFRL platelet-derived growth factor receptor-like
POLH polymerase (DNA directed), eta
PTTG3P pituitary tumor-transforming 3, pseudogene
RAD54L2 RAD54-like 2 (S. cerevisiae)
RIN1 Ras and Rab interactor 1
RNF2 ring finger protein 2
RPGR retinitis pigmentosa GTPase regulator
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAMD9 sterile alpha motif domain containing 9
SCAI suppressor of cancer cell invasion
SCARA3 scavenger receptor class A, member 3
SDC3 syndecan 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35F6 solute carrier family 35, member F6
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SREBF1 sterol regulatory element binding transcription factor 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYT17 synaptotagmin XVII
TBC1D12 TBC1 domain family, member 12
TCTN2 tectonic family member 2
TM7SF2 transmembrane 7 superfamily member 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNC119 unc-119 homolog (C. elegans)
UQCRC1 ubiquinol-cytochrome c reductase core protein I
USP19 ubiquitin specific peptidase 19
WDR33 WD repeat domain 33
WNT5B wingless-type MMTV integration site family, member 5B
ZBTB22 zinc finger and BTB domain containing 22
ZFP30 ZFP30 zinc finger protein
ZNF205 zinc finger protein 205
ZNF408 zinc finger protein 408
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747