diphenhydramine-1871 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the diphenhydramine-1871 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ALDOB aldolase B, fructose-bisphosphate
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARL4C ADP-ribosylation factor-like 4C
ARNTL aryl hydrocarbon receptor nuclear translocator-like
BAZ2A bromodomain adjacent to zinc finger domain, 2A
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNT1 cyclin T1
CD70 CD70 molecule
CDK10 cyclin-dependent kinase 10
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDYL chromodomain protein, Y-like
CEP104 centrosomal protein 104kDa
CFAP45 cilia and flagella associated protein 45
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CRYL1 crystallin, lambda 1
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DIAPH1 diaphanous-related formin 1
DSTYK dual serine/threonine and tyrosine protein kinase
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
ERO1L ERO1-like (S. cerevisiae)
EVI5 ecotropic viral integration site 5
FAM63B family with sequence similarity 63, member B
FICD FIC domain containing
FST follistatin
GLP1R glucagon-like peptide 1 receptor
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GUSBP3 glucuronidase, beta pseudogene 3
HFE hemochromatosis
HIPK3 homeodomain interacting protein kinase 3
HSPA4 heat shock 70kDa protein 4
IFI44L interferon-induced protein 44-like
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL27RA interleukin 27 receptor, alpha
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KCTD20 potassium channel tetramerization domain containing 20
KIAA0100 KIAA0100
KRI1 KRI1 homolog (S. cerevisiae)
KRIT1 KRIT1, ankyrin repeat containing
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MCPH1 microcephalin 1
MED1 mediator complex subunit 1
MIIP migration and invasion inhibitory protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTMR2 myotubularin related protein 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO19 myosin XIX
NDE1 nudE neurodevelopment protein 1
NDRG2 NDRG family member 2
NEK9 NIMA-related kinase 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD2 nucleotide-binding oligomerization domain containing 2
NUP98 nucleoporin 98kDa
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PEX5 peroxisomal biogenesis factor 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRUNE prune exopolyphosphatase
PTN pleiotrophin
PURA purine-rich element binding protein A
RARS arginyl-tRNA synthetase
RBM48 RNA binding motif protein 48
REST RE1-silencing transcription factor
RNFT1 ring finger protein, transmembrane 1
RPL35A ribosomal protein L35a
RUNX1 runt-related transcription factor 1
SCCPDH saccharopine dehydrogenase (putative)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIGLEC9 sialic acid binding Ig-like lectin 9
SIN3B SIN3 transcription regulator family member B
SLC48A1 solute carrier family 48 (heme transporter), member 1
SOCS6 suppressor of cytokine signaling 6
SOGA1 suppressor of glucose, autophagy associated 1
SOX12 SRY (sex determining region Y)-box 12
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRD5A3 steroid 5 alpha-reductase 3
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT2 signal transducer and activator of transcription 2, 113kDa
STX16 syntaxin 16
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TEX2 testis expressed 2
TPP1 tripeptidyl peptidase I
TRMT61A tRNA methyltransferase 61A
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF24 zinc finger protein 24
ZNF324 zinc finger protein 324
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABHD4 abhydrolase domain containing 4
ANXA3 annexin A3
BTNL3 butyrophilin-like 3
C17ORF70 chromosome 17 open reading frame 70
C1ORF21 chromosome 1 open reading frame 21
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
CBX4 chromobox homolog 4
CCDC88C coiled-coil domain containing 88C
CD3D CD3d molecule, delta (CD3-TCR complex)
CENPB centromere protein B, 80kDa
CEP170B centrosomal protein 170B
CHMP6 charged multivesicular body protein 6
COL15A1 collagen, type XV, alpha 1
CPNE7 copine VII
CPTP ceramide-1-phosphate transfer protein
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNMBP dynamin binding protein
DTX4 deltex 4, E3 ubiquitin ligase
DUSP2 dual specificity phosphatase 2
ENO3 enolase 3 (beta, muscle)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM57A family with sequence similarity 57, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FLCN folliculin
FOSL1 FOS-like antigen 1
GAREM GRB2 associated, regulator of MAPK1
GIPC1 GIPC PDZ domain containing family, member 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GSPT2 G1 to S phase transition 2
GTF2IRD1 GTF2I repeat domain containing 1
HIST1H3H histone cluster 1, H3h
IFNAR1 interferon (alpha, beta and omega) receptor 1
INO80D INO80 complex subunit D
KIAA0319L KIAA0319-like
LIMD2 LIM domain containing 2
LIN7A lin-7 homolog A (C. elegans)
LINC00260 long intergenic non-protein coding RNA 260
LSP1 lymphocyte-specific protein 1
LY6E lymphocyte antigen 6 complex, locus E
MAGEB2 melanoma antigen family B2
MAGEF1 melanoma antigen family F1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCMBP minichromosome maintenance complex binding protein
MFSD11 major facilitator superfamily domain containing 11
MTERF4 mitochondrial transcription termination factor 4
NARFL nuclear prelamin A recognition factor-like
NPDC1 neural proliferation, differentiation and control, 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDGFD platelet derived growth factor D
PHKG2 phosphorylase kinase, gamma 2 (testis)
PRAF2 PRA1 domain family, member 2
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRR4 proline rich 4 (lacrimal)
PRR7 proline rich 7 (synaptic)
RAB23 RAB23, member RAS oncogene family
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF167 ring finger protein 167
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPGR retinitis pigmentosa GTPase regulator
SALL2 spalt-like transcription factor 2
SCAMP4 secretory carrier membrane protein 4
SCRN3 secernin 3
SENP7 SUMO1/sentrin specific peptidase 7
SFT2D2 SFT2 domain containing 2
SIK1 salt-inducible kinase 1
SLC41A3 solute carrier family 41, member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPATA2L spermatogenesis associated 2-like
SPIDR scaffolding protein involved in DNA repair
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAP1 signal transducing adaptor family member 1
TBL3 transducin (beta)-like 3
TCTN2 tectonic family member 2
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM177 transmembrane protein 177
TNNT1 troponin T type 1 (skeletal, slow)
TRAF1 TNF receptor-associated factor 1
TRIM66 tripartite motif containing 66
TRPV2 transient receptor potential cation channel, subfamily V, member 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VILL villin-like
WT1-AS WT1 antisense RNA
YEATS2 YEATS domain containing 2
YY2 YY2 transcription factor
ZBTB25 zinc finger and BTB domain containing 25
ZBTB44 zinc finger and BTB domain containing 44
ZMAT5 zinc finger, matrin-type 5
ZNF137P zinc finger protein 137, pseudogene
ZNF250 zinc finger protein 250
ZNF34 zinc finger protein 34
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF665 zinc finger protein 665